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Aliases for GON4L Gene

Aliases for GON4L Gene

  • Gon-4 Like 2 3 5
  • YY1AP Related Protein 2 3
  • GON4 3 4
  • Gon-4 Homolog (C.Elegans) 2
  • Gon-4-Like (C. Elegans) 2
  • YY1AP-Related Protein1 3
  • GON-4-Like Protein 3
  • 2610100B20Rik 3
  • Gon-4 Homolog 3
  • GON-4 Homolog 4
  • KIAA1606 4
  • GON-4 3
  • YARP 3

External Ids for GON4L Gene

Previous HGNC Symbols for GON4L Gene

  • GON4

Previous GeneCards Identifiers for GON4L Gene

  • GC01M153986
  • GC01M127081

Summaries for GON4L Gene

GeneCards Summary for GON4L Gene

GON4L (Gon-4 Like) is a Protein Coding gene. Diseases associated with GON4L include Blood Group, Globoside System and Endophthalmitis. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is YY1AP1.

UniProtKB/Swiss-Prot for GON4L Gene

  • Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.

Gene Wiki entry for GON4L Gene

Additional gene information for GON4L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GON4L Gene

Genomics for GON4L Gene

GeneHancer (GH) Regulatory Elements for GON4L Gene

Promoters and enhancers for GON4L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J155856 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 684.6 +0.5 450 5.7 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 GON4L SYT11 KHDC4 ENSG00000271267 RRNAD1 CLK2 THBS3 DAP3 FLAD1 PYGO2
GH01J155242 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 262.3 +615.2 615158 2.9 FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 GBA GON4L KHDC4 CLK2 ENSG00000271267 MSTO1 MSTO2P RUSC1-AS1 THBS3 SHC1
GH01J154998 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 125.7 +854.9 854949 11.3 CLOCK MLX YBX1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 ZBTB7B GON4L CLK2 UBAP2L KHDC4 ENSG00000271267 THBS3 RUSC1-AS1 SHC1 MSTO1
GH01J156111 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 97.7 -262.0 -261989 19.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 LMNA GON4L CLK2 KHDC4 RRNAD1 LOC246784 MSTO1 MSTO2P PRCC ENSG00000271267
GH01J154965 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 104.8 +887.3 887346 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 SHC1 CKS1B UBAP2L GON4L CLK2 KHDC4 THBS3 YY1AP1 KRTCAP2 ENSG00000271267
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GON4L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GON4L gene promoter:
  • YY1
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • RFX1
  • c-Myb
  • POU2F1a
  • AP-4
  • POU2F1
  • Pax-5

Genomic Locations for GON4L Gene

Genomic Locations for GON4L Gene
chr1:155,749,658-155,859,400
(GRCh38/hg38)
Size:
109,743 bases
Orientation:
Minus strand
chr1:155,719,508-155,829,191
(GRCh37/hg19)
Size:
109,684 bases
Orientation:
Minus strand

Genomic View for GON4L Gene

Genes around GON4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GON4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GON4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GON4L Gene

Proteins for GON4L Gene

  • Protein details for GON4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3T8J9-GON4L_HUMAN
    Recommended name:
    GON-4-like protein
    Protein Accession:
    Q3T8J9
    Secondary Accessions:
    • B7ZBL4
    • Q14C93
    • Q3T8J8
    • Q5VYZ5
    • Q5W0D5
    • Q6AWA6
    • Q6P1Q6
    • Q7Z3L3
    • Q8IY79
    • Q9BQI1
    • Q9HCG6

    Protein attributes for GON4L Gene

    Size:
    2241 amino acids
    Molecular mass:
    248620 Da
    Quaternary structure:
    • Found in a complex with YY1, SIN3A and HDAC1.
    SequenceCaution:
    • Sequence=CAD97829.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH10549.1; Type=Erroneous termination; Positions=1114; Note=Translated as Tyr.; Evidence={ECO:0000305};

    Alternative splice isoforms for GON4L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GON4L Gene

Post-translational modifications for GON4L Gene

  • Ubiquitination at isoforms=2, 3534
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GON4L Gene

Domains & Families for GON4L Gene

Gene Families for GON4L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GON4L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GON4L: view

No data available for UniProtKB/Swiss-Prot for GON4L Gene

Function for GON4L Gene

Molecular function for GON4L Gene

UniProtKB/Swiss-Prot Function:
Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.

Phenotypes From GWAS Catalog for GON4L Gene

Gene Ontology (GO) - Molecular Function for GON4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003712 transcription coregulator activity IBA --
GO:0003714 transcription corepressor activity IEA --
genes like me logo Genes that share ontologies with GON4L: view
genes like me logo Genes that share phenotypes with GON4L: view

Animal Model Products

CRISPR Products

miRNA for GON4L Gene

miRTarBase miRNAs that target GON4L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GON4L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GON4L Gene

Localization for GON4L Gene

Subcellular locations from UniProtKB/Swiss-Prot for GON4L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GON4L gene
Compartment Confidence
nucleus 5
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GON4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with GON4L: view

Pathways & Interactions for GON4L Gene

SuperPathways for GON4L Gene

No Data Available

Gene Ontology (GO) - Biological Process for GON4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0030183 B cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with GON4L: view

No data available for Pathways by source and SIGNOR curated interactions for GON4L Gene

Drugs & Compounds for GON4L Gene

No Compound Related Data Available

Transcripts for GON4L Gene

Unigene Clusters for GON4L Gene

Gon-4-like (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GON4L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GON4L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - - - - - - -
SP9: - -
SP10: -
SP11: -
SP12: -
SP13:

ExUns: 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30
SP1:
SP2: -
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GON4L Gene

GeneLoc Exon Structure for
GON4L
ECgene alternative splicing isoforms for
GON4L

Expression for GON4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GON4L Gene

Protein differential expression in normal tissues from HIPED for GON4L Gene

This gene is overexpressed in Plasma (47.3) and Lung (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GON4L Gene



Protein tissue co-expression partners for GON4L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GON4L Gene:

GON4L

SOURCE GeneReport for Unigene cluster for GON4L Gene:

Hs.656361

Evidence on tissue expression from TISSUES for GON4L Gene

  • Nervous system(4.5)
  • Eye(4.2)
  • Intestine(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with GON4L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GON4L Gene

Orthologs for GON4L Gene

This gene was present in the common ancestor of animals.

Orthologs for GON4L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GON4L 34 33
  • 99.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GON4L 33
  • 87.86 (n)
-- 34
  • 86 (a)
ManyToMany
-- 34
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 83 (a)
OneToMany
GON4L 33
  • 82.9 (n)
mouse
(Mus musculus)
Mammalia Gon4l 16 34 33
  • 80.67 (n)
rat
(Rattus norvegicus)
Mammalia Gon4l 33
  • 80.13 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GON4L 33
  • 64.76 (n)
-- 34
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gon4l 33
  • 63.72 (n)
Str.10093 33
zebrafish
(Danio rerio)
Actinopterygii gon4l 34
  • 36 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta mute 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2667 34
  • 27 (a)
ManyToMany
Species where no ortholog for GON4L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GON4L Gene

ENSEMBL:
Gene Tree for GON4L (if available)
TreeFam:
Gene Tree for GON4L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GON4L: view image

Paralogs for GON4L Gene

Paralogs for GON4L Gene

(2) SIMAP similar genes for GON4L Gene using alignment to 5 proteins:

  • GON4L_HUMAN
  • Q14BN2_HUMAN
  • Q1ED43_HUMAN
  • Q6IPZ3_HUMAN
  • Q6PHZ4_HUMAN

Pseudogenes.org Pseudogenes for GON4L Gene

genes like me logo Genes that share paralogs with GON4L: view

Variants for GON4L Gene

Sequence variations from dbSNP and Humsavar for GON4L Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000069795 -- 155,806,121(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000085655 -- 155,790,699(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000091600 -- 155,843,794(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000122370 -- 155,800,094(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000160186 -- 155,776,012(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GON4L Gene

Variant ID Type Subtype PubMed ID
esv2718429 CNV deletion 23290073
esv33869 CNV loss 17666407
esv3587633 CNV loss 21293372
nsv1003170 CNV gain 25217958
nsv3065 CNV deletion 18451855
nsv428246 CNV gain 18775914
nsv521958 CNV loss 19592680
nsv946422 CNV duplication 23825009
nsv946423 CNV duplication 23825009

Variation tolerance for GON4L Gene

Residual Variation Intolerance Score: 4.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GON4L Gene

Human Gene Mutation Database (HGMD)
GON4L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GON4L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GON4L Gene

Disorders for GON4L Gene

MalaCards: The human disease database

(2) MalaCards diseases for GON4L Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
blood group, globoside system
  • glob
endophthalmitis
- elite association - COSMIC cancer census association via MalaCards
Search GON4L in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GON4L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GON4L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GON4L Gene

Publications for GON4L Gene

  1. The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. (PMID: 21454521) Lu P … Colgan JD (The Journal of biological chemistry 2011) 2 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. An anthropoid-specific segmental duplication on human chromosome 1q22. (PMID: 16545939) Kuryshev VY … Wiemann S (Genomics 2006) 2 3 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GON4L Gene

Sources for GON4L Gene

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