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Aliases for MED1 Gene

Aliases for MED1 Gene

  • Mediator Complex Subunit 1 2 3 4 5
  • Thyroid Hormone Receptor-Associated Protein Complex 220 KDa Component 3 4
  • Vitamin D Receptor-Interacting Protein Complex Component DRIP205 3 4
  • Peroxisome Proliferator-Activated Receptor-Binding Protein 3 4
  • Activator-Recruited Cofactor 205 KDa Component 3 4
  • P53 Regulatory Protein RB18A 3 4
  • TR-Interacting Protein 2 3 4
  • PPAR-Binding Protein 3 4
  • PPARGBP 3 4
  • CRSP200 3 4
  • DRIP205 3 4
  • DRIP230 3 4
  • TRAP220 3 4
  • PPARBP 3 4
  • ARC205 3 4
  • TRIP-2 3 4
  • TRIP2 3 4
  • CRSP1 3 4
  • RB18A 3 4
  • PBP 3 4
  • Thyroid Hormone Receptor-Associated Protein Complex Component TRAP220 3
  • Mediator Of RNA Polymerase II Transcription Subunit 1 3
  • Vitamin D Receptor-Interacting Protein 230 KD 3
  • Thyroid Receptor Interacting Protein 2 3
  • Thyroid Receptor-Interacting Protein 2 4
  • PPARG Binding Protein 3
  • PPAR Binding Protein 2

External Ids for MED1 Gene

Previous HGNC Symbols for MED1 Gene

  • TRIP2
  • PPARGBP
  • PPARBP

Previous GeneCards Identifiers for MED1 Gene

  • GC17M034815
  • GC17M037560
  • GC17M033354

Summaries for MED1 Gene

Entrez Gene Summary for MED1 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED1 Gene

MED1 (Mediator Complex Subunit 1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include chromatin binding and receptor activity.

UniProtKB/Swiss-Prot for MED1 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Gene Wiki entry for MED1 Gene

Additional gene information for MED1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED1 Gene

Genomics for MED1 Gene

GeneHancer (GH) Regulatory Elements for MED1 Gene

Promoters and enhancers for MED1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I039449 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563.9 +0.1 82 2.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 MED1 CDK12 SNORA21 MSL1 RPL19 STARD3 LOC105371762 SNORD124 RPL23 ENSG00000214546
GH17I040306 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 174.7 -866.2 -866239 22.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RARA MED1 SMARCE1 SNORD124 CDK12 MED24 MSL1 TMEM99 CDC6 WIPF2
GH17I038745 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 125.5 +701.5 701513 8.6 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PCGF2 PSMB3 LOC100287808 MED1 CDK12 LOC105371762 SNORA21 RPL23 RPL19 CISD3
GH17I040138 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 134.3 -689.1 -689053 3.2 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 MCM3 CASC3 GC17M040140 MED1 SNORD124 SMARCE1 CDK12 MED24 MSL1 STARD3 IGFBP4
GH17I038823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 107.9 +626.3 626348 3 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CWC25 MIR4727 MED1 CDK12 SNORA21 LOC105371762 RPL23 STARD3 RPL19 PIP4K2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MED1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MED1 gene promoter:

Genomic Locations for MED1 Gene

Genomic Locations for MED1 Gene
chr17:39,404,285-39,451,286
(GRCh38/hg38)
Size:
47,002 bases
Orientation:
Minus strand
chr17:37,560,538-37,607,539
(GRCh37/hg19)

Genomic View for MED1 Gene

Genes around MED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED1 Gene

Proteins for MED1 Gene

  • Protein details for MED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15648-MED1_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 1
    Protein Accession:
    Q15648
    Secondary Accessions:
    • A2RRQ6
    • O43810
    • O75447
    • Q6P9H7
    • Q6PK58
    • Q9HD39

    Protein attributes for MED1 Gene

    Size:
    1581 amino acids
    Molecular mass:
    168478 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RORA, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Interacts with YWHAH. Interacts with CLOCK; this interaction requires the presence of THRAP3 (By similarity). Interacts with GATA1 and CCAR1. Interacts with NR4A3 (By similarity).
    SequenceCaution:
    • Sequence=AAC39854.1; Type=Frameshift; Positions=543, 545; Evidence={ECO:0000305}; Sequence=AAH06517.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAA73867.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MED1 Gene

    Alternative splice isoforms for MED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED1 Gene

Post-translational modifications for MED1 Gene

  • Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED1 Gene

No data available for DME Specific Peptides for MED1 Gene

Domains & Families for MED1 Gene

Gene Families for MED1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MED1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15648

UniProtKB/Swiss-Prot:

MED1_HUMAN :
  • Belongs to the Mediator complex subunit 1 family.
Family:
  • Belongs to the Mediator complex subunit 1 family.
genes like me logo Genes that share domains with MED1: view

Function for MED1 Gene

Molecular function for MED1 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Phenotypes From GWAS Catalog for MED1 Gene

Gene Ontology (GO) - Molecular Function for MED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA,ISS --
GO:0001047 core promoter binding IDA,IEA 17641689
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
genes like me logo Genes that share ontologies with MED1: view
genes like me logo Genes that share phenotypes with MED1: view

Animal Models for MED1 Gene

MGI Knock Outs for MED1:

Clone Products

  • Addgene plasmids for MED1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED1 Gene

Localization for MED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED1 Gene

Nucleus. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED1 gene
Compartment Confidence
nucleus 5
peroxisome 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA,IEA 10235267
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 16314496
genes like me logo Genes that share ontologies with MED1: view

Pathways & Interactions for MED1 Gene

genes like me logo Genes that share pathways with MED1: view

SIGNOR curated interactions for MED1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0000902 cell morphogenesis IMP 17223341
GO:0001525 angiogenesis IEA,ISS --
GO:0001701 in utero embryonic development IEA --
GO:0001889 liver development IEA --
genes like me logo Genes that share ontologies with MED1: view

Drugs & Compounds for MED1 Gene

(6) Drugs for MED1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Becocalcidiol Investigational Pharma Target 0

(6) Additional Compounds for MED1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MED1: view

Transcripts for MED1 Gene

Unigene Clusters for MED1 Gene

Mediator complex subunit 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for MED1

Alternative Splicing Database (ASD) splice patterns (SP) for MED1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2: - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for MED1 Gene

GeneLoc Exon Structure for
MED1
ECgene alternative splicing isoforms for
MED1

Expression for MED1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED1 Gene

This gene is overexpressed in Lung (16.8), Blymphocyte (8.6), Monocytes (6.8), and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED1 Gene



Protein tissue co-expression partners for MED1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MED1 Gene:

MED1

SOURCE GeneReport for Unigene cluster for MED1 Gene:

Hs.643754

mRNA Expression by UniProt/SwissProt for MED1 Gene:

Q15648-MED1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for MED1 Gene

  • Liver(4.6)
  • Intestine(4.4)
  • Heart(4.3)
  • Nervous system(4.3)
  • Skin(3.3)
  • Lung(2.9)
  • Kidney(2.7)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with MED1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED1 Gene

Orthologs for MED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED1 33 34
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia MED1 33 34
  • 95.22 (n)
dog
(Canis familiaris)
Mammalia MED1 33 34
  • 94.88 (n)
oppossum
(Monodelphis domestica)
Mammalia MED1 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med1 33
  • 90.73 (n)
mouse
(Mus musculus)
Mammalia Med1 33 16 34
  • 90.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MED1 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED1 33 34
  • 78.94 (n)
lizard
(Anolis carolinensis)
Reptilia MED1 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med1 33
  • 67.85 (n)
Str.18690 33
zebrafish
(Danio rerio)
Actinopterygii med1 34
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta MED1 34
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToOne
Species where no ortholog for MED1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED1 Gene

ENSEMBL:
Gene Tree for MED1 (if available)
TreeFam:
Gene Tree for MED1 (if available)

Paralogs for MED1 Gene

No data available for Paralogs for MED1 Gene

Variants for MED1 Gene

Sequence variations from dbSNP and Humsavar for MED1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs193921049 uncertain-significance, Malignant tumor of prostate 39,431,132(-) A/C coding_sequence_variant, intron_variant, missense_variant
rs1000135705 -- 39,430,655(-) T/C intron_variant
rs1000226222 -- 39,429,414(-) G/C intron_variant
rs1000361938 -- 39,416,924(-) C/T intron_variant
rs1000434360 -- 39,419,465(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MED1 Gene

Variant ID Type Subtype PubMed ID
nsv1055612 CNV gain 25217958
nsv1063848 CNV gain 25217958
nsv1146669 OTHER inversion 26484159

Variation tolerance for MED1 Gene

Residual Variation Intolerance Score: 0.958% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED1 Gene

Disorders for MED1 Gene

Additional Disease Information for MED1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MED1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED1 Gene

Publications for MED1 Gene

  1. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 22 44 58
  2. Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. (PMID: 15471764) Wu Q … Safe S (The Journal of biological chemistry 2004) 3 4 22 58
  3. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. (PMID: 14636573) Wallberg AE … Roeder RG (Molecular cell 2003) 3 4 22 58
  4. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. (PMID: 12218053) Wang Q … Fondell JD (The Journal of biological chemistry 2002) 3 4 22 58
  5. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. (PMID: 10733574) Rachez C … Freedman LP (Molecular and cellular biology 2000) 3 4 22 58

Products for MED1 Gene

  • Addgene plasmids for MED1

Sources for MED1 Gene