Aliases for UGT1A3 Gene
External Ids for UGT1A3 Gene
Previous GeneCards Identifiers for UGT1A3 Gene
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided by RefSeq, Jul 2008]
GeneCards Summary for UGT1A3 Gene
UGT1A3 (UDP Glucuronosyltransferase Family 1 Member A3) is a Protein Coding gene. Diseases associated with UGT1A3 include Gilbert Syndrome and Drug-Induced Hepatitis. Among its related pathways are Acetaminophen Pathway (therapeutic doses), Pharmacokinetics and Constitutive Androstane Receptor Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A5.
UniProtKB/Swiss-Prot for UGT1A3 Gene
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.