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Aliases for UNC93A Gene

Aliases for UNC93A Gene

  • Unc-93 Homolog A 2 3 5
  • Unc-93A 3 4
  • DJ366N23.2 (Putative C. Elegans UNC-93 (Protein 1, C46F11.1) C-Terminal LIKE) 3
  • DJ366N23.1 (Putative C. Elegans UNC-93 (Protein 1, C46F11.1) LIKE) 3
  • Unc-93 Homolog A (C. Elegans) 2
  • Unc93 (C.Elegans) Homolog A 2
  • Protein Unc-93 Homolog A 3
  • Unc93 Homolog A 3
  • DJ366N23.1 3
  • DJ366N23.2 3
  • HmUnc-93A 4

External Ids for UNC93A Gene

Previous GeneCards Identifiers for UNC93A Gene

  • GC06P167058
  • GC06P167578
  • GC06P167614
  • GC06P167675
  • GC06P167624
  • GC06P167704
  • GC06P165177

Summaries for UNC93A Gene

GeneCards Summary for UNC93A Gene

UNC93A (Unc-93 Homolog A) is a Protein Coding gene. An important paralog of this gene is UNC93B1.

Additional gene information for UNC93A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UNC93A Gene

Genomics for UNC93A Gene

GeneHancer (GH) Regulatory Elements for UNC93A Gene

Promoters and enhancers for UNC93A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J167289 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 663 +20.6 20636 3.8 ELF3 FOXA2 ARID4B DMAP1 ZNF48 RAD21 RARA YY1 ZNF614 CREM UNC93A LOC102724220 TTLL2 GC06P167312
GH06J167270 Enhancer 0.6 ENCODE dbSUPER 667 +1.1 1120 3.2 FOXA2 FOXA3 CREM UNC93A LOC102724220 GC06P167312
GH06J167265 Enhancer 1.4 Ensembl ENCODE dbSUPER 20.4 -3.7 -3672 4.3 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 NFKBIZ GC06P167267 UNC93A LOC102724220
GH06J167223 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.2 -44.5 -44543 6.9 FOXA2 ARID4B SIN3A DMAP1 SP5 MXD4 MIER2 PPARG NFIL3 SSRP1 ENSG00000280707 UNC93A GPR31 LOC100420305
GH06J167243 Enhancer 0.9 Ensembl ENCODE dbSUPER 26.3 -26.1 -26086 2.7 SP1 NANOG POLR2A POU5F1 UNC93A LOC102724220 LOC102725048 GC06M167245
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UNC93A on UCSC Golden Path with GeneCards custom track

Genomic Locations for UNC93A Gene

Genomic Locations for UNC93A Gene
44,861 bases
Plus strand
44,851 bases
Plus strand

Genomic View for UNC93A Gene

Genes around UNC93A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UNC93A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UNC93A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UNC93A Gene

Proteins for UNC93A Gene

  • Protein details for UNC93A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein unc-93 homolog A
    Protein Accession:
    Secondary Accessions:
    • B3KRP5
    • Q4QQJ4
    • Q5JZD6

    Protein attributes for UNC93A Gene

    457 amino acids
    Molecular mass:
    50270 Da
    Quaternary structure:
    No Data Available
    • Although UNC93A gene is located in a region of the genome frequently associated with ovarian cancer, no evidence have been found for a tumor suppressor function.
    • Sequence=CAI42706.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UNC93A Gene


neXtProt entry for UNC93A Gene

Post-translational modifications for UNC93A Gene

Antibody Products

  • Abcam antibodies for UNC93A
  • Santa Cruz Biotechnology (SCBT) Antibodies for UNC93A

No data available for DME Specific Peptides for UNC93A Gene

Domains & Families for UNC93A Gene

Gene Families for UNC93A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for UNC93A Gene

Suggested Antigen Peptide Sequences for UNC93A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the unc-93 family.
  • Belongs to the unc-93 family.
genes like me logo Genes that share domains with UNC93A: view

Function for UNC93A Gene

Phenotypes From GWAS Catalog for UNC93A Gene

Gene Ontology (GO) - Molecular Function for UNC93A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with UNC93A: view
genes like me logo Genes that share phenotypes with UNC93A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UNC93A Gene

Localization for UNC93A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UNC93A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UNC93A gene
Compartment Confidence
plasma membrane 5
endosome 1

Gene Ontology (GO) - Cellular Components for UNC93A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 12381271
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 12381271
genes like me logo Genes that share ontologies with UNC93A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UNC93A Gene

Pathways & Interactions for UNC93A Gene

SuperPathways for UNC93A Gene

No Data Available

Interacting Proteins for UNC93A Gene

Gene Ontology (GO) - Biological Process for UNC93A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with UNC93A: view

No data available for Pathways by source and SIGNOR curated interactions for UNC93A Gene

Drugs & Compounds for UNC93A Gene

No Compound Related Data Available

Transcripts for UNC93A Gene

Unigene Clusters for UNC93A Gene

Unc-93 homolog A (C. elegans):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UNC93A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5

Relevant External Links for UNC93A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UNC93A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UNC93A Gene

mRNA differential expression in normal tissues according to GTEx for UNC93A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x20.8), Skin - Not Sun Exposed (Suprapubic) (x14.4), and Liver (x9.6).

Protein differential expression in normal tissues from HIPED for UNC93A Gene

This gene is overexpressed in Fetal Liver (48.6) and Urine (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UNC93A Gene

Protein tissue co-expression partners for UNC93A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UNC93A Gene:


SOURCE GeneReport for Unigene cluster for UNC93A Gene:


mRNA Expression by UniProt/SwissProt for UNC93A Gene:

Tissue specificity: Expressed in testis, small intestine, spleen, prostate and ovary.

Evidence on tissue expression from TISSUES for UNC93A Gene

  • Liver(4.1)
  • Spleen(4)
genes like me logo Genes that share expression patterns with UNC93A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for UNC93A Gene

Orthologs for UNC93A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UNC93A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UNC93A 34 33
  • 98.91 (n)
(Canis familiaris)
Mammalia UNC93A 34 33
  • 82.09 (n)
(Bos Taurus)
Mammalia UNC93A 34 33
  • 78.34 (n)
(Mus musculus)
Mammalia Gm9992 34 33
  • 76.24 (n)
Unc93a 34
  • 72 (a)
Gm8597 34
  • 46 (a)
Unc93a2 16
(Rattus norvegicus)
Mammalia Unc93a 33
  • 75.26 (n)
(Ornithorhynchus anatinus)
Mammalia UNC93A 34
  • 67 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
-- 34
  • 60 (a)
(Gallus gallus)
Aves UNC93A 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
-- 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487981 33
  • 61.1 (n)
Str.13374 33
(Danio rerio)
Actinopterygii unc93a 34 33
  • 62.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4928 34 33
  • 52.74 (n)
CG2121 34
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000834 33
  • 52.23 (n)
(Caenorhabditis elegans)
Secernentea unc-93 34 33
  • 45.96 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09470 33
  • 44.47 (n)
(Oryza sativa)
Liliopsida Os12g0566900 33
  • 45.12 (n)
Species where no ortholog for UNC93A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UNC93A Gene

Gene Tree for UNC93A (if available)
Gene Tree for UNC93A (if available)
Evolutionary constrained regions (ECRs) for UNC93A: view image

Paralogs for UNC93A Gene

Paralogs for UNC93A Gene

(1) SIMAP similar genes for UNC93A Gene using alignment to 2 proteins:

  • D6RFH7_HUMAN Pseudogenes for UNC93A Gene

genes like me logo Genes that share paralogs with UNC93A: view

Variants for UNC93A Gene

Sequence variations from dbSNP and Humsavar for UNC93A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000022843 -- 167,280,920(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000035796 -- 167,287,338(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000078011 -- 167,276,354(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000151414 -- 167,267,952(+) T/C upstream_transcript_variant
rs1000181623 -- 167,280,519(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UNC93A Gene

Variant ID Type Subtype PubMed ID
dgv1034e201 CNV deletion 23290073
dgv11056n54 CNV gain 21841781
dgv1240e214 CNV gain 21293372
dgv6194n100 CNV gain 25217958
dgv6196n100 CNV gain 25217958
dgv6197n100 CNV loss 25217958
dgv6198n100 CNV gain 25217958
esv24545 CNV gain+loss 19812545
esv2733230 CNV deletion 23290073
esv2733231 CNV deletion 23290073
esv2759492 CNV gain 17122850
esv2761058 CNV gain 21179565
esv3282385 CNV deletion 24192839
esv34252 CNV gain 17911159
esv3435434 CNV duplication 20981092
esv3576253 CNV gain 25503493
esv3611649 CNV gain 21293372
esv3611654 CNV loss 21293372
esv3611655 CNV gain 21293372
esv3611656 CNV loss 21293372
esv3611657 CNV loss 21293372
esv3611658 CNV gain 21293372
nsv1024654 CNV loss 25217958
nsv464141 CNV gain 19166990
nsv464145 CNV loss 19166990
nsv470873 CNV gain 18288195
nsv509170 CNV insertion 20534489
nsv517210 CNV gain+loss 19592680
nsv605338 CNV gain 21841781
nsv605343 CNV loss 21841781
nsv605344 CNV loss 21841781
nsv605345 CNV gain 21841781
nsv7389 OTHER inversion 18451855
nsv970192 CNV duplication 23825009

Variation tolerance for UNC93A Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.52; 94.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UNC93A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UNC93A Gene

Disorders for UNC93A Gene

Additional Disease Information for UNC93A

No disorders were found for UNC93A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UNC93A Gene

Publications for UNC93A Gene

  1. The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer. (PMID: 12381271) Liu Y … Ganesan TS (BMC genetics 2002) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for UNC93A Gene

Sources for UNC93A Gene

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