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Aliases for MRPL39 Gene

Aliases for MRPL39 Gene

  • Mitochondrial Ribosomal Protein L39 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein ML39 3 4
  • 39S Ribosomal Protein L5, Mitochondrial 3 4
  • C21orf92 3 4
  • MRP-L39 3 4
  • MRP-L5 3 4
  • L39mt 3 4
  • MRPL5 3 4
  • RPML5 3 4
  • L5mt 3 4
  • 39S Ribosomal Protein L39, Mitochondrial 3
  • MSTP003 3
  • PRED22 3
  • PRED66 3

External Ids for MRPL39 Gene

Previous GeneCards Identifiers for MRPL39 Gene

  • GC21M023536
  • GC21M025879
  • GC21M026957
  • GC21M012361

Summaries for MRPL39 Gene

Entrez Gene Summary for MRPL39 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL39 Gene

MRPL39 (Mitochondrial Ribosomal Protein L39) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is TARSL2.

Gene Wiki entry for MRPL39 Gene

Additional gene information for MRPL39 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL39 Gene

Genomics for MRPL39 Gene

GeneHancer (GH) Regulatory Elements for MRPL39 Gene

Promoters and enhancers for MRPL39 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J025606 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 678 +0.1 127 2.4 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 ZC3H11A MRPL39 GABPA RPL13AP7 LINC00515
GH21J026021 Promoter 0.5 EPDnew 650 -414.1 -414112 0.1 MRPL39 GC21P025992 ENSG00000224541 APP
GH21J025638 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 25.3 -31.8 -31833 2.6 RB1 ZNF335 GLIS2 ZNF366 ZNF143 BCLAF1 CREM EGR2 SMARCA5 SP3 JAM2 MRPL39 GABPA ATP5PF RNGTTP1
GH21J025561 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 20.5 +45.2 45164 3 SMAD1 RB1 STAT5A BATF RAD21 KLF5 IRF4 ZNF207 ZNF143 ATF7 MIR155HG JAM2 MRPL39 GC21P025574
GH21J025570 Enhancer 1.2 Ensembl ENCODE dbSUPER 27.4 +34.6 34617 4.8 HDGF HDAC1 PKNOX1 ATF1 RB1 STAT5A BATF IRF4 EGR1 ATF7 GC21P025574 MIR155 MRPL39 MIR155HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL39 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MRPL39 Gene

Genomic Locations for MRPL39 Gene
22,191 bases
Minus strand
21,862 bases
Minus strand

Genomic View for MRPL39 Gene

Genes around MRPL39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL39 Gene

Proteins for MRPL39 Gene

  • Protein details for MRPL39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L39, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • C9JYA5
    • Q32Q74
    • Q5QTR3
    • Q96Q65
    • Q9BSQ7
    • Q9BZV6
    • Q9NX44

    Protein attributes for MRPL39 Gene

    338 amino acids
    Molecular mass:
    38712 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    • Sequence=AAF44696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13505.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91177.1; Type=Frameshift; Positions=72; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL39 Gene

    Alternative splice isoforms for MRPL39 Gene


neXtProt entry for MRPL39 Gene

Post-translational modifications for MRPL39 Gene

  • Ubiquitination at Lys315
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL39 Gene

No data available for DME Specific Peptides for MRPL39 Gene

Domains & Families for MRPL39 Gene

Gene Families for MRPL39 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL39 Gene

Suggested Antigen Peptide Sequences for MRPL39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrion-specific ribosomal protein mL39 family.
  • Belongs to the mitochondrion-specific ribosomal protein mL39 family.
genes like me logo Genes that share domains with MRPL39: view

Function for MRPL39 Gene

Phenotypes From GWAS Catalog for MRPL39 Gene

Gene Ontology (GO) - Molecular Function for MRPL39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0004827 proline-tRNA ligase activity IBA --
genes like me logo Genes that share ontologies with MRPL39: view
genes like me logo Genes that share phenotypes with MRPL39: view

Animal Model Products

miRNA for MRPL39 Gene

miRTarBase miRNAs that target MRPL39

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL39 Gene

Localization for MRPL39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL39 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL39 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MRPL39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA,IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11167009
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL39: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL39 Gene

Pathways & Interactions for MRPL39 Gene

genes like me logo Genes that share pathways with MRPL39: view

Gene Ontology (GO) - Biological Process for MRPL39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006433 prolyl-tRNA aminoacylation IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL39: view

No data available for SIGNOR curated interactions for MRPL39 Gene

Drugs & Compounds for MRPL39 Gene

No Compound Related Data Available

Transcripts for MRPL39 Gene

mRNA/cDNA for MRPL39 Gene

Unigene Clusters for MRPL39 Gene

Mitochondrial ribosomal protein L39:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL39 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: -
SP3: -

Relevant External Links for MRPL39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL39 Gene

Protein differential expression in normal tissues from HIPED for MRPL39 Gene

This gene is overexpressed in Breast (37.0) and Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL39 Gene

Protein tissue co-expression partners for MRPL39 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL39 Gene:


SOURCE GeneReport for Unigene cluster for MRPL39 Gene:


mRNA Expression by UniProt/SwissProt for MRPL39 Gene:

Tissue specificity: Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific.

Evidence on tissue expression from TISSUES for MRPL39 Gene

  • Heart(4.3)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with MRPL39: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL39 Gene

Orthologs for MRPL39 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL39 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL39 34 33
  • 98.87 (n)
(Canis familiaris)
Mammalia MRPL39 34 33
  • 89.41 (n)
(Bos Taurus)
Mammalia MRPL39 34 33
  • 88.23 (n)
(Mus musculus)
Mammalia Mrpl39 16 34 33
  • 84.7 (n)
(Rattus norvegicus)
Mammalia Mrpl39 33
  • 81.25 (n)
(Monodelphis domestica)
Mammalia MRPL39 34
  • 74 (a)
(Gallus gallus)
Aves MRPL39 34 33
  • 71.82 (n)
(Anolis carolinensis)
Reptilia MRPL39 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl39 33
  • 66.44 (n)
Str.11934 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16628 33
(Danio rerio)
Actinopterygii mrpl39 34 33
  • 54.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL39 34 33
  • 48.8 (n)
mRpL5 35
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010644 33
  • 46.19 (n)
(Caenorhabditis elegans)
Secernentea tars-1 34
  • 9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 34
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
Species where no ortholog for MRPL39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL39 Gene

Gene Tree for MRPL39 (if available)
Gene Tree for MRPL39 (if available)
Evolutionary constrained regions (ECRs) for MRPL39: view image

Paralogs for MRPL39 Gene

Paralogs for MRPL39 Gene Pseudogenes for MRPL39 Gene

genes like me logo Genes that share paralogs with MRPL39: view

Variants for MRPL39 Gene

Sequence variations from dbSNP and Humsavar for MRPL39 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000113119 -- 25,594,777(-) A/T intron_variant
rs1000418789 -- 25,594,498(-) C/T intron_variant
rs1000453628 -- 25,596,442(-) C/A intron_variant
rs1000618450 -- 25,590,003(-) T/C intron_variant
rs1000668971 -- 25,588,050(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL39 Gene

Variant ID Type Subtype PubMed ID
nsv510501 OTHER sequence alteration 20534489

Variation tolerance for MRPL39 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL39 Gene

Disorders for MRPL39 Gene

Additional Disease Information for MRPL39

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL39 Gene

Publications for MRPL39 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4 58
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MRPL39 Gene

Sources for MRPL39 Gene

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