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Aliases for UBL3 Gene

Aliases for UBL3 Gene

  • Ubiquitin Like 3 2 3 5
  • Membrane-Anchored Ubiquitin-Fold Protein 3 4
  • Protein HCG-1 3 4
  • HsMUB 3 4
  • PNSC1 3 4
  • MUB 3 4
  • Ubiquitin-Like Protein 3 3
  • Ubiquitin-Like 3 2
  • HCG-1 3

External Ids for UBL3 Gene

Previous HGNC Symbols for UBL3 Gene

  • PNSC1

Previous GeneCards Identifiers for UBL3 Gene

  • GC13M028318
  • GC13M024318
  • GC13M029268
  • GC13M028136
  • GC13M029236
  • GC13M030338
  • GC13M011152

Summaries for UBL3 Gene

GeneCards Summary for UBL3 Gene

UBL3 (Ubiquitin Like 3) is a Protein Coding gene.

Gene Wiki entry for UBL3 Gene

Additional gene information for UBL3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBL3 Gene

Genomics for UBL3 Gene

GeneHancer (GH) Regulatory Elements for UBL3 Gene

Promoters and enhancers for UBL3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J029846 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +1.7 1675 4.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 POLR2B UBL3 SLC7A1 LOC105370139
GH13J030462 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.5 -614.1 -614138 5.3 HDGF FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 HMGB1 USPL1 LINC01058 KATNAL1 UBL3 GC13M030460 MFAP1P1
GH13J030112 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.1 -263.5 -263493 3.2 FOXA2 ARID4B SIN3A ZNF2 YY1 ELK1 ZNF207 ZNF143 RUNX3 RXRA UBL3 HMGB1 LINC00365 GC13M030142 PIR52167
GH13J029922 Enhancer 1.3 Ensembl ENCODE 10.5 -73.8 -73845 4.7 CLOCK FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 LINC01058 USPL1 UBL3 LINC00572 LINC00297
GH13J030107 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 -258.4 -258371 4.1 PKNOX1 FOXA2 NFIB NEUROD1 KLF17 MZF1 SIN3A RAD21 YY1 EGR1 LINC00365 UBL3 GC13M030142 PIR52167
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBL3 gene promoter:
  • LCR-F1
  • AP-2gamma
  • Egr-4
  • CUTL1
  • IRF-1
  • AP-4
  • AML1a
  • HOXA3
  • MyoD

Genomic Locations for UBL3 Gene

Genomic Locations for UBL3 Gene
86,314 bases
Minus strand
86,314 bases
Minus strand

Genomic View for UBL3 Gene

Genes around UBL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL3 Gene

Proteins for UBL3 Gene

  • Protein details for UBL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-like protein 3
    Protein Accession:
    Secondary Accessions:
    • B2R4J1
    • Q5RL72
    • Q5VZS0
    • Q6FIG8
    • Q96SG7

    Protein attributes for UBL3 Gene

    117 amino acids
    Molecular mass:
    13157 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBL3 Gene

neXtProt entry for UBL3 Gene

Post-translational modifications for UBL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for UBL3
  • Santa Cruz Biotechnology (SCBT) Antibodies for UBL3

No data available for DME Specific Peptides for UBL3 Gene

Domains & Families for UBL3 Gene

Gene Families for UBL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBL3 Gene

Suggested Antigen Peptide Sequences for UBL3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBL3: view

No data available for UniProtKB/Swiss-Prot for UBL3 Gene

Function for UBL3 Gene

Molecular function for UBL3 Gene

GENATLAS Biochemistry:
ubiquitin-like protein 3, Drosophila homolog,highly conserved in man and C elegans

Phenotypes From GWAS Catalog for UBL3 Gene

genes like me logo Genes that share phenotypes with UBL3: view

Animal Model Products

Clone Products

  • Addgene plasmids for UBL3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBL3 Gene

Localization for UBL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL3 Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBL3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with UBL3: view

Pathways & Interactions for UBL3 Gene

No Data Available

Interacting Proteins for UBL3 Gene

Gene Ontology (GO) - Biological Process for UBL3 Gene


No data available for Pathways by source and SIGNOR curated interactions for UBL3 Gene

Drugs & Compounds for UBL3 Gene

No Compound Related Data Available

Transcripts for UBL3 Gene

mRNA/cDNA for UBL3 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(307) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBL3 Gene

Ubiquitin-like 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for UBL3

Alternative Splicing Database (ASD) splice patterns (SP) for UBL3 Gene

No ASD Table

Relevant External Links for UBL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBL3 Gene

This gene is overexpressed in Cervix (43.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBL3 Gene:


SOURCE GeneReport for Unigene cluster for UBL3 Gene:


mRNA Expression by UniProt/SwissProt for UBL3 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for UBL3 Gene

  • Nervous system(4.9)
  • Skin(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with UBL3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBL3 Gene

Orthologs for UBL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBL3 34 33
  • 100 (n)
(Monodelphis domestica)
Mammalia UBL3 34
  • 99 (a)
(Canis familiaris)
Mammalia UBL3 34 33
  • 97.72 (n)
(Ornithorhynchus anatinus)
Mammalia UBL3 34
  • 94 (a)
(Bos Taurus)
Mammalia UBL3 34 33
  • 93.16 (n)
(Mus musculus)
Mammalia Ubl3 16 34 33
  • 88.32 (n)
(Rattus norvegicus)
Mammalia Ubl3 33
  • 87.46 (n)
(Gallus gallus)
Aves UBL3 34 33
  • 86.89 (n)
(Anolis carolinensis)
Reptilia UBL3 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl3 33
  • 84.62 (n)
Str.5748 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.21417 33
(Danio rerio)
Actinopterygii ubl3a 34 33
  • 79.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013294 33
  • 64.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta UBL3 34 35 33
  • 63.74 (n)
(Caenorhabditis elegans)
Secernentea C46F11.6 34 33
  • 55.15 (n)
Species where no ortholog for UBL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBL3 Gene

Gene Tree for UBL3 (if available)
Gene Tree for UBL3 (if available)
Evolutionary constrained regions (ECRs) for UBL3: view image

Paralogs for UBL3 Gene

No data available for Paralogs for UBL3 Gene

Variants for UBL3 Gene

Sequence variations from dbSNP and Humsavar for UBL3 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000017030 -- 29,849,358(-) G/C intron_variant
rs1000059176 -- 29,807,895(-) T/C intron_variant
rs1000061417 -- 29,786,776(-) G/A intron_variant
rs1000078232 -- 29,816,412(-) G/A intron_variant
rs1000121705 -- 29,764,030(-) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UBL3 Gene

Variant ID Type Subtype PubMed ID
esv1537429 CNV deletion 17803354

Variation tolerance for UBL3 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL3 Gene

Disorders for UBL3 Gene

Additional Disease Information for UBL3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UBL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBL3 Gene

Publications for UBL3 Gene

  1. Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene. (PMID: 10375635) Chadwick BP … Frischauf AM (Gene 1999) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. (PMID: 20460270) Garcia-Barceló MM … Tam PK (Human molecular genetics 2010) 3 44 58
  4. MUBs, a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation. (PMID: 16831869) Downes BP … Vierstra RD (The Journal of biological chemistry 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for UBL3 Gene

Sources for UBL3 Gene

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