External Ids for TLR9 Gene
Previous GeneCards Identifiers for TLR9 Gene
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017]
GeneCards Summary for TLR9 Gene
TLR9 (Toll Like Receptor 9) is a Protein Coding gene. Diseases associated with TLR9 include Meningococcal Meningitis and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome. Among its related pathways are Th1 Differentiation Pathway and Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and siRNA binding. An important paralog of this gene is ENSG00000173366.
UniProtKB/Swiss-Prot Summary for TLR9 Gene
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366).