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Aliases for CLDN22 Gene

Aliases for CLDN22 Gene

  • Claudin 22 2 3 5
  • Claudin-22 3
  • CLDN21 3

External Ids for CLDN22 Gene

Previous GeneCards Identifiers for CLDN22 Gene

  • GC04U990095
  • GC04M184937
  • GC04M184615
  • GC04M184477
  • GC04M184239
  • GC04M179999

Summaries for CLDN22 Gene

Entrez Gene Summary for CLDN22 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN22 Gene

CLDN22 (Claudin 22) is a Protein Coding gene. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Cell junction organization. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN24.

UniProtKB/Swiss-Prot for CLDN22 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN22 Gene

Additional gene information for CLDN22 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN22 Gene

Genomics for CLDN22 Gene

GeneHancer (GH) Regulatory Elements for CLDN22 Gene

Promoters and enhancers for CLDN22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J183347 Enhancer 1.2 Ensembl ENCODE 11.9 -28.7 -28744 4 PKNOX1 ATF1 POLR2B ZNF766 ELK1 FOS ATF7 CAVIN1 NCOA1 REST CLDN24 TRAPPC11 RNU6-1053P CDKN2AIP CLDN22 LOC100533630
GH04J183397 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.2 -78.1 -78140 2.2 ATF1 ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF48 ZNF766 CBX5 ZNF143 CDKN2AIP CLDN24 CLDN22 LOC100533630 LOC100127981
GH04J183353 Enhancer 0.7 ENCODE 11.9 -34.2 -34246 2.8 MEIS2 PKNOX1 JUN MAX FEZF1 MCM2 FOSL1 ZNF776 E2F8 ZNF366 CLDN24 TRAPPC11 CLDN22 CDKN2AIP RNU6-1053P LOC100533630
GH04J183396 Enhancer 0.8 ENCODE 10.2 -74.8 -74819 0.1 PKNOX1 ATF1 NFRKB TCF12 GATA2 ETV6 CREM ZBTB2 CEBPB ZEB2 CDKN2AIP CLDN22 CLDN24 LOC100533630 LOC100127981
GH04J183395 Enhancer 0.7 ENCODE 10.2 -75.7 -75686 1.4 MEIS2 PKNOX1 ATF1 NFRKB E4F1 FOSL1 POLR2A ETV6 TRIM24 CREM CDKN2AIP CLDN24 CLDN22 LOC100533630 LOC100127981
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLDN22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLDN22 gene promoter:
  • AP-2beta
  • AP-2alphaA
  • AP-2alpha
  • AP-2gamma
  • FOXD3
  • E47
  • Hand1
  • Evi-1
  • C/EBPalpha

Genomic Locations for CLDN22 Gene

Genomic Locations for CLDN22 Gene
chr4:183,318,067-183,320,774
(GRCh38/hg38)
Size:
2,708 bases
Orientation:
Minus strand
chr4:184,239,220-184,241,927
(GRCh37/hg19)
Size:
2,708 bases
Orientation:
Minus strand

Genomic View for CLDN22 Gene

Genes around CLDN22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN22 Gene

Proteins for CLDN22 Gene

  • Protein details for CLDN22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7P3-CLD22_HUMAN
    Recommended name:
    Claudin-22
    Protein Accession:
    Q8N7P3

    Protein attributes for CLDN22 Gene

    Size:
    220 amino acids
    Molecular mass:
    24509 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLDN22 Gene

Post-translational modifications for CLDN22 Gene

No Post-translational modifications

Other Protein References for CLDN22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN22 Gene

Domains & Families for CLDN22 Gene

Gene Families for CLDN22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for CLDN22 Gene

Suggested Antigen Peptide Sequences for CLDN22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7P3

UniProtKB/Swiss-Prot:

CLD22_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN22: view

Function for CLDN22 Gene

Molecular function for CLDN22 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Ontology (GO) - Molecular Function for CLDN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN22: view
genes like me logo Genes that share phenotypes with CLDN22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN22

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLDN22 Gene

Localization for CLDN22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN22 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN22 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for CLDN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN22 Gene

Pathways & Interactions for CLDN22 Gene

genes like me logo Genes that share pathways with CLDN22: view

Gene Ontology (GO) - Biological Process for CLDN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN22: view

No data available for SIGNOR curated interactions for CLDN22 Gene

Drugs & Compounds for CLDN22 Gene

(1) Drugs for CLDN22 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CLDN22: view

Transcripts for CLDN22 Gene

mRNA/cDNA for CLDN22 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN22

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN22 Gene

No ASD Table

Relevant External Links for CLDN22 Gene

GeneLoc Exon Structure for
CLDN22
ECgene alternative splicing isoforms for
CLDN22

Expression for CLDN22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN22 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLDN22 Gene:

CLDN22
genes like me logo Genes that share expression patterns with CLDN22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN22 Gene

Orthologs for CLDN22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN22 34 33
  • 98.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CLDN22 33
  • 84.47 (n)
-- 34
  • 82 (a)
ManyToMany
-- 34
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cldn22 33
  • 79.26 (n)
mouse
(Mus musculus)
Mammalia Cldn22 16 34 33
  • 78.96 (n)
Cldn24 34
  • 73 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CLDN22 33
  • 78.23 (n)
-- 34
  • 78 (a)
ManyToMany
-- 34
  • 73 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
ManyToMany
-- 34
  • 73 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC100858888 33
  • 73.33 (n)
-- 34
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn22 33
  • 65.58 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-98f17.3 33
  • 54.59 (n)
CLDN22 34
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10090 34
  • 29 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 20 (a)
ManyToMany
Species where no ortholog for CLDN22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN22 Gene

ENSEMBL:
Gene Tree for CLDN22 (if available)
TreeFam:
Gene Tree for CLDN22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLDN22: view image

Paralogs for CLDN22 Gene

Paralogs for CLDN22 Gene

(18) SIMAP similar genes for CLDN22 Gene using alignment to 1 proteins:

  • CLD22_HUMAN
genes like me logo Genes that share paralogs with CLDN22: view

Variants for CLDN22 Gene

Sequence variations from dbSNP and Humsavar for CLDN22 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000040175 -- 183,317,850(-) G/C downstream_transcript_variant
rs1000706899 -- 183,318,362(-) T/C 3_prime_UTR_variant
rs1001042453 -- 183,319,114(-) T/C 3_prime_UTR_variant
rs1001078414 -- 183,318,691(-) A/G 3_prime_UTR_variant
rs1003180672 -- 183,320,052(-) A/G coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN22 Gene

Variant ID Type Subtype PubMed ID
nsv1029647 CNV gain 25217958
nsv1030766 CNV gain 25217958

Variation tolerance for CLDN22 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDN22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDN22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN22 Gene

Disorders for CLDN22 Gene

Additional Disease Information for CLDN22

No disorders were found for CLDN22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLDN22 Gene

Publications for CLDN22 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. (PMID: 12736707) Katoh M … Katoh M (International journal of molecular medicine 2003) 3 22 58
  4. The claudins. (PMID: 19706201) Lal-Nag M … Morin PJ (Genome biology 2009) 3 58
  5. Structure and function of claudins. (PMID: 18036336) Krause G … Blasig IE (Biochimica et biophysica acta 2008) 3 58

Products for CLDN22 Gene

Sources for CLDN22 Gene

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