Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SHC3 Gene

Aliases for SHC3 Gene

  • SHC Adaptor Protein 3 2 3 5
  • SHC (Src Homology 2 Domain Containing) Transforming Protein 3 2 3
  • SHC-Transforming Protein C 3 4
  • SH2 Domain Protein C3 3 4
  • Neuronal Shc 3 4
  • Protein Rai 3 4
  • N-Shc 3 4
  • NSHC 3 4
  • SHCC 3 4
  • Src Homology 2 Domain-Containing Transforming Protein C3 3
  • Src Homology 2 Domain-Containing-Transforming Protein C3 4
  • Src Homology 2 Domain Containing Transforming Protein C3 2
  • SHC-Transforming Protein 3 3
  • Shc3 P51 3
  • RAI 3

External Ids for SHC3 Gene

Previous GeneCards Identifiers for SHC3 Gene

  • GC09M082643
  • GC09M083496
  • GC09M085215
  • GC09M087117
  • GC09M088857
  • GC09M090817
  • GC09M091628
  • GC09M061453

Summaries for SHC3 Gene

GeneCards Summary for SHC3 Gene

SHC3 (SHC Adaptor Protein 3) is a Protein Coding gene. Diseases associated with SHC3 include Sarcomatous Intrahepatic Cholangiocarcinoma and Sclerosing Hepatic Carcinoma. Among its related pathways are Focal Adhesion and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.

UniProtKB/Swiss-Prot for SHC3 Gene

  • Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Gene Wiki entry for SHC3 Gene

Additional gene information for SHC3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHC3 Gene

Genomics for SHC3 Gene

GeneHancer (GH) Regulatory Elements for SHC3 Gene

Promoters and enhancers for SHC3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J089175 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 667.8 +3.4 3445 5.4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 ETS1 GLIS2 ATF7 SHC3 SECISBP2 C9orf47 ENSG00000224945
GH09J089309 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.1 -130.2 -130235 6.4 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B CKS2 LOC105376136 MIR3153 GC09M089309 SHC3 SECISBP2 SEMA4D
GH09J089136 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 27.2 +43.7 43729 4.4 STAT1 ZNF687 JUND POLR2A MAX CEBPB FOS EP300 ZNF592 SHC3 ENSG00000224945 CKS2
GH09J089152 Enhancer 1.1 Ensembl ENCODE dbSUPER 22.9 +27.5 27540 3.2 HDAC1 MEIS2 PKNOX1 JUN BRCA1 FOSL1 POLR2A FOSL2 ETV6 FOS SHC3 ENSG00000224945 CKS2
GH09J089020 Enhancer 0.9 Ensembl ENCODE 5.3 +160.0 159977 4 ESRRA JUN RFX5 FOSL1 CTBP1 GATA3 ZNF316 NFE2 FOSL2 FOS SHC3 GC09M089006 ENSG00000224945
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SHC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SHC3 gene promoter:
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • Lmo2
  • C/EBPbeta
  • POU3F2 (N-Oct-5b)
  • PPAR-gamma2
  • PPAR-gamma1
  • HSF1 (long)
  • C/EBPalpha
  • HSF1short

Genomic Locations for SHC3 Gene

Genomic Locations for SHC3 Gene
176,302 bases
Minus strand
172,997 bases
Minus strand

Genomic View for SHC3 Gene

Genes around SHC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHC3 Gene

Proteins for SHC3 Gene

  • Protein details for SHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SHC-transforming protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5T7I7
    • Q8TAP2
    • Q9UCX5

    Protein attributes for SHC3 Gene

    594 amino acids
    Molecular mass:
    64056 Da
    Quaternary structure:
    • Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.

    Alternative splice isoforms for SHC3 Gene


neXtProt entry for SHC3 Gene

Post-translational modifications for SHC3 Gene

Other Protein References for SHC3 Gene

No data available for DME Specific Peptides for SHC3 Gene

Domains & Families for SHC3 Gene

Gene Families for SHC3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SHC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SHC3: view

No data available for UniProtKB/Swiss-Prot for SHC3 Gene

Function for SHC3 Gene

Molecular function for SHC3 Gene

UniProtKB/Swiss-Prot Function:
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Phenotypes From GWAS Catalog for SHC3 Gene

Gene Ontology (GO) - Molecular Function for SHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine residue binding IPI 20624904
GO:0004871 obsolete signal transducer activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 11877420
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with SHC3: view
genes like me logo Genes that share phenotypes with SHC3: view

Animal Models for SHC3 Gene

MGI Knock Outs for SHC3:

Animal Model Products

Clone Products

  • Addgene plasmids for SHC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHC3 Gene

Localization for SHC3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHC3 gene
Compartment Confidence
cytosol 5
plasma membrane 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with SHC3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SHC3 Gene

Pathways & Interactions for SHC3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Gastric cancer
3 Glioma
4 Focal Adhesion
5 ErbB signaling pathway
genes like me logo Genes that share pathways with SHC3: view

SIGNOR curated interactions for SHC3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 8808684
GO:0007173 epidermal growth factor receptor signaling pathway TAS 8808684
GO:0007265 Ras protein signal transduction TAS --
genes like me logo Genes that share ontologies with SHC3: view

Drugs & Compounds for SHC3 Gene

(1) Drugs for SHC3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SHC3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SHC3: view

Transcripts for SHC3 Gene

mRNA/cDNA for SHC3 Gene

Unigene Clusters for SHC3 Gene

SHC (Src homology 2 domain containing) transforming protein 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for SHC3

Alternative Splicing Database (ASD) splice patterns (SP) for SHC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - -

Relevant External Links for SHC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHC3 Gene

mRNA differential expression in normal tissues according to GTEx for SHC3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.2), Brain - Frontal Cortex (BA9) (x5.8), and Brain - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for SHC3 Gene

This gene is overexpressed in Frontal cortex (45.1) and Ovary (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SHC3 Gene

Protein tissue co-expression partners for SHC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SHC3 Gene:


SOURCE GeneReport for Unigene cluster for SHC3 Gene:


mRNA Expression by UniProt/SwissProt for SHC3 Gene:

Tissue specificity: Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.

Evidence on tissue expression from TISSUES for SHC3 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with SHC3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SHC3 Gene

Orthologs for SHC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHC3 34 33
  • 99.38 (n)
(Rattus norvegicus)
Mammalia Shc3 33
  • 88.14 (n)
(Canis familiaris)
Mammalia SHC3 34 33
  • 87.61 (n)
(Mus musculus)
Mammalia Shc3 16 34 33
  • 87.24 (n)
(Bos Taurus)
Mammalia SHC3 34 33
  • 86.09 (n)
(Monodelphis domestica)
Mammalia SHC3 34
  • 64 (a)
(Gallus gallus)
Aves SHC3 34 33
  • 69.83 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia shc3 33
  • 66.04 (n)
(Danio rerio)
Actinopterygii SHC3 34
  • 66 (a)
LOC100332111 33
  • 64.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Shc 34 35
  • 38 (a)
(Caenorhabditis elegans)
Secernentea shc-1 34
  • 29 (a)
Species where no ortholog for SHC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SHC3 Gene

Gene Tree for SHC3 (if available)
Gene Tree for SHC3 (if available)
Evolutionary constrained regions (ECRs) for SHC3: view image

Paralogs for SHC3 Gene

Paralogs for SHC3 Gene

(9) SIMAP similar genes for SHC3 Gene using alignment to 2 proteins:

  • Q5T7I8_HUMAN
genes like me logo Genes that share paralogs with SHC3: view

Variants for SHC3 Gene

Sequence variations from dbSNP and Humsavar for SHC3 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000034630 -- 89,056,285(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000066862 -- 89,166,970(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000090307 -- 89,048,119(-) C/G/T genic_downstream_transcript_variant, intron_variant
rs1000096116 -- 89,031,874(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000113545 -- 89,133,589(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SHC3 Gene

Variant ID Type Subtype PubMed ID
dgv4472e59 CNV duplication 20981092
dgv4473e59 CNV duplication 20981092
esv2554035 CNV insertion 19546169
esv26782 CNV loss 19812545
esv2738726 CNV deletion 23290073
esv29340 CNV gain+loss 19812545
esv3310572 CNV novel sequence insertion 20981092
esv3446910 CNV insertion 20981092
esv3573288 CNV loss 25503493
esv3621014 CNV gain 21293372
nsv1077559 CNV duplication 25765185
nsv1132740 CNV duplication 24896259
nsv1147400 CNV duplication 26484159
nsv614825 CNV gain 21841781
nsv614826 CNV loss 21841781
nsv6608 CNV deletion 18451855
nsv819886 CNV loss 19587683
nsv831651 CNV gain 17160897

Variation tolerance for SHC3 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHC3 Gene

Disorders for SHC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SHC3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sarcomatous intrahepatic cholangiocarcinoma
  • sarcomatoid intrahepatic cholangiocarcinoma
sclerosing hepatic carcinoma
  • sclerosing hepatocellular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search SHC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SHC3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SHC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHC3 Gene

Publications for SHC3 Gene

  1. N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. (PMID: 8808684) Nakamura T … Mori N (Oncogene 1996) 2 3 4 22 58
  2. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PMID: 8760305) Pelicci G … Pelicci PG (Oncogene 1996) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. (PMID: 17179996) Li MD … Ma JZ (Molecular psychiatry 2007) 3 44 58
  5. Domain-specific function of ShcC docking protein in neuroblastoma cells. (PMID: 15735675) Miyake I … Sakai R (Oncogene 2005) 3 22 58

Products for SHC3 Gene

Sources for SHC3 Gene

Loading form....