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Aliases for SPA17 Gene

Aliases for SPA17 Gene

  • Sperm Autoantigenic Protein 17 2 3 4 5
  • Cancer/Testis Antigen 22 2 3 4
  • Sperm Protein 17 3 4
  • CT22 3 4
  • SP17 3 4
  • Sperm Surface Protein Sp17 3
  • SP17-1 3
  • Sp17-1 4

External Ids for SPA17 Gene

Previous GeneCards Identifiers for SPA17 Gene

  • GC11P126544
  • GC11P126057
  • GC11P124577
  • GC11P124081
  • GC11P124048
  • GC11P120486
  • GC11P124545

Summaries for SPA17 Gene

Entrez Gene Summary for SPA17 Gene

  • This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]

GeneCards Summary for SPA17 Gene

SPA17 (Sperm Autoantigenic Protein 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot for SPA17 Gene

  • Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).

Gene Wiki entry for SPA17 Gene

Additional gene information for SPA17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPA17 Gene

Genomics for SPA17 Gene

GeneHancer (GH) Regulatory Elements for SPA17 Gene

Promoters and enhancers for SPA17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124672 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 666.3 -0.3 -299 2.7 ARID4B SIN3A DMAP1 BRCA1 ZNF48 YY1 POLR2B ZNF143 ATF7 RUNX3 SPA17 SIAE RNA5SP352
GH11J124717 Enhancer 1.3 FANTOM5 Ensembl ENCODE 21.2 +44.1 44137 1.3 KLF17 MZF1 FEZF1 BATF IRF4 ZNF335 GLIS2 ZNF366 SCRT2 ATF7 SPA17 ESAM NRGN ENSG00000255045 VSIG2 SIAE LOC101929340 ROBO3 ROBO4 GC11P124740
GH11J124642 Enhancer 1.3 FANTOM5 Ensembl ENCODE 12.1 -29.7 -29743 2.5 ATF1 PKNOX1 ARNT YY1 TCF12 POLR2B ZNF766 E2F8 ZNF143 FOS ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
GH11J124757 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.7 +87.3 87339 6.4 HDGF ATF1 ZFP64 ARID4B SIN3A ZNF2 ZNF48 YY1 ETS1 SLC30A9 ESAM ROBO4 VSIG2 SPA17 NRGN GC11P124760 LOC101929340
GH11J124768 Enhancer 0.9 ENCODE dbSUPER 11.7 +96.8 96814 3.3 JUN ZNF384 TEAD3 FOSL1 ZFHX2 ZNF316 EGR1 FOSL2 FOS EGR2 NRGN SIAE SPA17 LOC100507283 MSANTD2 ROBO3 VSIG2 ESAM ENSG00000254509
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPA17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPA17 gene promoter:
  • c-Ets-1
  • HNF-4alpha2
  • IRF-1
  • HNF-4alpha1
  • NF-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • Egr-4
  • NF-AT

Genomic Locations for SPA17 Gene

Genomic Locations for SPA17 Gene
23,748 bases
Plus strand
23,721 bases
Plus strand

Genomic View for SPA17 Gene

Genes around SPA17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPA17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPA17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPA17 Gene

Proteins for SPA17 Gene

  • Protein details for SPA17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm surface protein Sp17
    Protein Accession:
    Secondary Accessions:
    • B2R4F2
    • Q9BXF7

    Protein attributes for SPA17 Gene

    151 amino acids
    Molecular mass:
    17406 Da
    Quaternary structure:
    • Homodimer (By similarity). May interact with ROPN1.

neXtProt entry for SPA17 Gene

Post-translational modifications for SPA17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPA17 Gene

No data available for DME Specific Peptides for SPA17 Gene

Domains & Families for SPA17 Gene

Gene Families for SPA17 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPA17 Gene

Suggested Antigen Peptide Sequences for SPA17 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPA17: view

No data available for UniProtKB/Swiss-Prot for SPA17 Gene

Function for SPA17 Gene

Molecular function for SPA17 Gene

UniProtKB/Swiss-Prot Function:
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).

Phenotypes From GWAS Catalog for SPA17 Gene

Gene Ontology (GO) - Molecular Function for SPA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15257753
GO:0005516 calmodulin binding IBA --
genes like me logo Genes that share ontologies with SPA17: view
genes like me logo Genes that share phenotypes with SPA17: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPA17 Gene

Localization for SPA17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPA17 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPA17 gene
Compartment Confidence
plasma membrane 3
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 18421703
GO:0005929 cilium IDA 18421703
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031514 motile cilium IDA 18421703
genes like me logo Genes that share ontologies with SPA17: view

Pathways & Interactions for SPA17 Gene

SuperPathways for SPA17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPA17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement NAS 18421703
GO:0007283 spermatogenesis TAS 8688458
GO:0007338 single fertilization TAS 8688458
GO:0007339 binding of sperm to zona pellucida IEA --
genes like me logo Genes that share ontologies with SPA17: view

No data available for Pathways by source and SIGNOR curated interactions for SPA17 Gene

Drugs & Compounds for SPA17 Gene

(1) Additional Compounds for SPA17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPA17: view

Transcripts for SPA17 Gene

mRNA/cDNA for SPA17 Gene

Unigene Clusters for SPA17 Gene

Sperm autoantigenic protein 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPA17 Gene

No ASD Table

Relevant External Links for SPA17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPA17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPA17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPA17 Gene

This gene is overexpressed in Testis (x22.0).

Protein differential expression in normal tissues from HIPED for SPA17 Gene

This gene is overexpressed in Ovary (53.6) and Testis (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPA17 Gene

Protein tissue co-expression partners for SPA17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPA17 Gene:


SOURCE GeneReport for Unigene cluster for SPA17 Gene:


mRNA Expression by UniProt/SwissProt for SPA17 Gene:

Tissue specificity: Testis and sperm specific.

Evidence on tissue expression from TISSUES for SPA17 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SPA17: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPA17 Gene

Orthologs for SPA17 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPA17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPA17 34 33
  • 100 (n)
(Bos Taurus)
Mammalia SPA17 34 33
  • 86.07 (n)
(Canis familiaris)
Mammalia SPA17 34 33
  • 85.11 (n)
(Rattus norvegicus)
Mammalia Spa17 33
  • 82.31 (n)
(Mus musculus)
Mammalia Spa17 16 34 33
  • 81.92 (n)
(Ornithorhynchus anatinus)
Mammalia SPA17 34
  • 69 (a)
(Monodelphis domestica)
Mammalia SPA17 34
  • 57 (a)
(Anolis carolinensis)
Reptilia SPA17 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spa17 33
  • 57.04 (n)
(Danio rerio)
Actinopterygii spa17 34
  • 12 (a)
(Caenorhabditis elegans)
Secernentea F39H12.3 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
Species where no ortholog for SPA17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPA17 Gene

Gene Tree for SPA17 (if available)
Gene Tree for SPA17 (if available)
Evolutionary constrained regions (ECRs) for SPA17: view image

Paralogs for SPA17 Gene Pseudogenes for SPA17 Gene

genes like me logo Genes that share paralogs with SPA17: view

No data available for Paralogs for SPA17 Gene

Variants for SPA17 Gene

Sequence variations from dbSNP and Humsavar for SPA17 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000162551 -- 124,683,734(+) C/A intron_variant
rs1000215927 -- 124,675,064(+) T/G intron_variant
rs1000272722 -- 124,674,841(+) A/T intron_variant
rs1000297954 -- 124,683,468(+) A/G intron_variant
rs1000318835 -- 124,688,662(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPA17 Gene

Variant ID Type Subtype PubMed ID
nsv1045156 CNV loss 25217958

Variation tolerance for SPA17 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPA17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPA17 Gene

Disorders for SPA17 Gene

Additional Disease Information for SPA17

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPA17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPA17 Gene

Publications for SPA17 Gene

  1. Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. (PMID: 8688458) Lea IA … O'Rand MG (Biochimica et biophysica acta 1996) 2 3 4 22 58
  2. A yeast two-hybrid system using Sp17 identified Ropporin as a novel cancer-testis antigen in hematologic malignancies. (PMID: 17551920) Li Z … Lim SH (International journal of cancer 2007) 3 4 22 58
  3. Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model. (PMID: 12393185) Buchli R … Robbins DL (Biochimica et biophysica acta 2002) 3 4 22 58
  4. Sperm protein 17 is a novel marker for predicting cisplatin response in esophageal squamous cancer cell lines. (PMID: 19685492) Kausar T … Ralhan R (International journal of cancer 2010) 3 22 58
  5. Sperm protein 17 is expressed in the sperm fibrous sheath. (PMID: 19604394) Chiriva-Internati M … Kast WM (Journal of translational medicine 2009) 3 22 58

Products for SPA17 Gene

Sources for SPA17 Gene

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