Aliases for PLAU Gene
External Ids for PLAU Gene
Previous GeneCards Identifiers for PLAU Gene
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for PLAU Gene
PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases associated with PLAU include Quebec Platelet Disorder and Alzheimer Disease. Among its related pathways are Complement and coagulation cascades and DNA Damage Response (only ATM dependent). Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PLAT.
UniProtKB/Swiss-Prot for PLAU Gene
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.