Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLAG1 Gene

Aliases for PLAG1 Gene

  • PLAG1 Zinc Finger 2 3 5
  • Pleiomorphic Adenoma Gene 1 2 3
  • Pleiomorphic Adenoma Gene 1 Protein 4
  • Zinc Finger Protein PLAG1 3
  • COL1A2/PLAG1 Fusion 3
  • HAS2/PLAG1 Fusion 3
  • ZNF912 3
  • SGPA 3
  • PSA 3

External Ids for PLAG1 Gene

Previous GeneCards Identifiers for PLAG1 Gene

  • GC08M056256
  • GC08M057012
  • GC08M056796
  • GC08M057123
  • GC08M057236
  • GC08M057073
  • GC08M052540

Summaries for PLAG1 Gene

Entrez Gene Summary for PLAG1 Gene

  • Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLAG1 Gene

PLAG1 (PLAG1 Zinc Finger) is a Protein Coding gene. Diseases associated with PLAG1 include Salivary Gland Adenoma, Pleomorphic and Silver-Russell Syndrome. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is PLAGL2.

UniProtKB/Swiss-Prot for PLAG1 Gene

  • Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.

Gene Wiki entry for PLAG1 Gene

Additional gene information for PLAG1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAG1 Gene

Genomics for PLAG1 Gene

GeneHancer (GH) Regulatory Elements for PLAG1 Gene

Promoters and enhancers for PLAG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J056209 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.2 187 3.7 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 POLR2B ZNF207 ZNF143 FOS CHCHD7 PLAG1 TGS1 RPS20 GC08M056160
GH08J056242 Enhancer 0.7 ENCODE 11.6 -30.8 -30793 0.2 CTCF RB1 MAX BMI1 RAD21 RFX5 CC2D1A ZNF207 SMC3 ZNF143 PLAG1 CHCHD7 RPS20 ENSG00000254216 PIR62677
GH08J056173 Enhancer 0.5 ENCODE 11.6 +37.4 37444 1.2 JUND JUN CREB1 FOSL2 FOS MAFK PLAG1 CHCHD7 MOS GC08M056160 ENSG00000221093 GC08M056122
GH08J056168 Enhancer 0.4 UCNEbase 10.8 +43.1 43111 0.4 CHCHD7 PLAG1 MOS GC08M056160 ENSG00000221093 GC08M056122
GH08J056167 Enhancer 0.3 ENCODE 10.8 +44.0 44027 0.2 SCRT2 MOS PLAG1 CHCHD7 GC08M056160 GC08M056122 ENSG00000221093
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLAG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLAG1 gene promoter:
  • LyF-1
  • Pbx1a
  • POU3F2
  • HNF-3beta
  • STAT3
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Nkx2-2
  • Evi-1

Genomic Locations for PLAG1 Gene

Genomic Locations for PLAG1 Gene
chr8:56,160,904-56,211,324
(GRCh38/hg38)
Size:
50,421 bases
Orientation:
Minus strand
chr8:57,073,463-57,123,883
(GRCh37/hg19)
Size:
50,421 bases
Orientation:
Minus strand

Genomic View for PLAG1 Gene

Genes around PLAG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAG1 Gene

Proteins for PLAG1 Gene

  • Protein details for PLAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DJT9-PLAG1_HUMAN
    Recommended name:
    Zinc finger protein PLAG1
    Protein Accession:
    Q6DJT9
    Secondary Accessions:
    • B4DLC2
    • Q59GH8
    • Q9Y4L2

    Protein attributes for PLAG1 Gene

    Size:
    500 amino acids
    Molecular mass:
    55909 Da
    Quaternary structure:
    • Interacts with KPNA2, which escorts protein to the nucleus via interaction with nuclear localization signal. Interacts with E3 SUMO-protein ligase PIAS1, PIAS2 and PIAS4.
    Miscellaneous:
    • Residual nuclear import after mutation of the nuclear localization signal is assigned to zinc finger domains of PLAG1.
    • When cultured cells transformed by PLAG1 overexpression are injected in nude mouse, rapidly growing tumors (fibrosarcomaS) are observed at the site of inoculation.
    SequenceCaution:
    • Sequence=BAD92368.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLAG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLAG1 Gene

Post-translational modifications for PLAG1 Gene

  • Sumoylated with SUMO1; which inhibits transcriptional activity, but does not affect nuclear localization. Blockers of sumoylation pathway such as SENP3 and inactive UBE2I increases transcriptional capacity. Sumoylation is increased in the presence of PIAS1.
  • Acetylated by lysine acetyltransferase EP300; which activates transcriptional capacity. Lysine residues that are sumoylated also seem to be target for acetylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLAG1 Gene

No data available for DME Specific Peptides for PLAG1 Gene

Domains & Families for PLAG1 Gene

Gene Families for PLAG1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for PLAG1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6DJT9

UniProtKB/Swiss-Prot:

PLAG1_HUMAN :
  • C2H2-type zinc fingers 3 interacts with DNA-binding site G-clusterinc fingers. C2H2-type zinc fingers 6 and 7 interact with DNA-binding site core sequence.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • C2H2-type zinc fingers 3 interacts with DNA-binding site G-clusterinc fingers. C2H2-type zinc fingers 6 and 7 interact with DNA-binding site core sequence.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with PLAG1: view

Function for PLAG1 Gene

Molecular function for PLAG1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
GENATLAS Biochemistry:
putative pleomorphic adenoma gene 1,not normally expressed in adult tissues,fused with beta catenin in adenomas,with translocation t(3;8)(p21;q12),see ADPL,PSA2 and with TCEA1 t(3;8)(p21;q12) in salivary adenomas (see PSA2)

Phenotypes From GWAS Catalog for PLAG1 Gene

Gene Ontology (GO) - Molecular Function for PLAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10646861
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10646861
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with PLAG1: view
genes like me logo Genes that share phenotypes with PLAG1: view

Human Phenotype Ontology for PLAG1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLAG1 Gene

MGI Knock Outs for PLAG1:

Animal Model Products

miRNA for PLAG1 Gene

miRTarBase miRNAs that target PLAG1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLAG1 Gene

Localization for PLAG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAG1 Gene

Nucleus. Note=Strong nucleolar localization when sumoylation is inhibited.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAG1 gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with PLAG1: view

Pathways & Interactions for PLAG1 Gene

SuperPathways for PLAG1 Gene

No Data Available

SIGNOR curated interactions for PLAG1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PLAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006915 apoptotic process IBA --
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with PLAG1: view

No data available for Pathways by source for PLAG1 Gene

Drugs & Compounds for PLAG1 Gene

(1) Drugs for PLAG1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430

(2) Additional Compounds for PLAG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLAG1: view

Transcripts for PLAG1 Gene

Unigene Clusters for PLAG1 Gene

Pleiomorphic adenoma gene 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAG1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: -
SP3: - -
SP4: - - - - -
SP5:

Relevant External Links for PLAG1 Gene

GeneLoc Exon Structure for
PLAG1
ECgene alternative splicing isoforms for
PLAG1

Expression for PLAG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLAG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLAG1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLAG1 Gene



Protein tissue co-expression partners for PLAG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLAG1 Gene:

PLAG1

SOURCE GeneReport for Unigene cluster for PLAG1 Gene:

Hs.14968

mRNA Expression by UniProt/SwissProt for PLAG1 Gene:

Q6DJT9-PLAG1_HUMAN
Tissue specificity: Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors.

Evidence on tissue expression from TISSUES for PLAG1 Gene

  • Nervous system(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAG1 Gene

Germ Layers:
  • endoderm
Systems:
  • digestive
Regions:
Head and neck:
  • head
  • mouth
  • salivary gland
genes like me logo Genes that share expression patterns with PLAG1: view

No data available for mRNA differential expression in normal tissues for PLAG1 Gene

Orthologs for PLAG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLAG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLAG1 34 33
  • 100 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLAG1 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLAG1 34 33
  • 91.78 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLAG1 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plag1 33
  • 89.85 (n)
mouse
(Mus musculus)
Mammalia Plag1 16 34 33
  • 89.65 (n)
cow
(Bos Taurus)
Mammalia PLAG1 34 33
  • 84.5 (n)
OneToOne
chicken
(Gallus gallus)
Aves PLAG1 34 33
  • 86.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLAG1 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plag1 33
  • 81.49 (n)
zebrafish
(Danio rerio)
Actinopterygii plag1 34 33
  • 67.31 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42726 34
  • 21 (a)
ManyToMany
CG2678 34
  • 16 (a)
ManyToMany
Species where no ortholog for PLAG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAG1 Gene

ENSEMBL:
Gene Tree for PLAG1 (if available)
TreeFam:
Gene Tree for PLAG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLAG1: view image

Paralogs for PLAG1 Gene

Paralogs for PLAG1 Gene

genes like me logo Genes that share paralogs with PLAG1: view

Variants for PLAG1 Gene

Sequence variations from dbSNP and Humsavar for PLAG1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000068162 -- 56,201,041(-) G/C intron_variant
rs1000141594 -- 56,173,370(-) C/T intron_variant
rs1000170602 -- 56,180,166(-) G/C intron_variant
rs1000322893 -- 56,179,283(-) T/A intron_variant
rs1000371259 -- 56,207,981(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLAG1 Gene

Variant ID Type Subtype PubMed ID
dgv12174n54 CNV gain 21841781
dgv158e203 CNV gain 21179565
dgv2082e212 CNV gain 25503493
dgv7229n100 CNV gain 25217958
esv26536 CNV gain 19812545
esv3617293 CNV gain 21293372
nsv1161764 CNV deletion 26073780
nsv433401 CNV gain 18776910
nsv442108 CNV gain 18776908

Variation tolerance for PLAG1 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLAG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAG1 Gene

Disorders for PLAG1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for PLAG1 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
salivary gland adenoma, pleomorphic
  • sgpa
silver-russell syndrome
  • srs
adenoma
  • acinar cell adenoma
pleomorphic adenoma
  • mixed tumor of the salivary gland
hepatoblastoma
  • hbl
- elite association - COSMIC cancer census association via MalaCards
Search PLAG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PLAG1_HUMAN
  • Note=A chromosomal aberration involving PLAG1 is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with constitutively expressed beta-catenin/CTNNB1. Fusion occurs in the 5-regulatory regions, leading to promoter swapping between the 2 genes and activation of PLAG1 expression in adenomas. The chimeric transcript is formed by fusion of CTNNB1 exon 1 to PLAG1 exon 3. Reciprocal fusion transcript consisting of PLAG1 exon 1 and CTNNB1 exon 2-16 is also revealed in some adenomas (PubMed:9020842, PubMed:10029085). Translocation t(3;8)(p21;q12) with transcription elongation factor SII/TCEA1. The fusion transcript is composed of 5-non-coding sequences as well as 63 nucleotides of the coding region of TCEA1 fused to the acceptor splice site of PLAG1 exon 3. The fusion transcript encodes a truncated TCEA1-PLAG1 protein of 90 AA as well as an apparently normal PLAG1 protein. Reciprocal fusion transcript PLAG1-TCEA1 is also present in one adenoma (PubMed:10029085, PubMed:16736500). Translocation t(5;8)(p13;q12) with leukemia inhibitory factor receptor LIFR. This fusion occured in the 5-non-coding sequences of both genes, exchanging regulatory control element while preserving the coding sequences (PubMed:9525740). Translocation t(6;8)(p21.3-22;q13) with Coiled-coil-helix-coiled-coil-helix domain-containing protein 7/CHCHD7. Fusion occurs in the 5 regulatory regions, leading to promoter swapping and up-regulation of PLAG1 expression (PubMed:16736500). Ectopic expression of PLAG1 under the control of promoters of distinct translocation partner genes is a general pathogenetic mechanism for pleiomorphic adenomas with 8q aberrations. These fusion genes are likely to be found in adenomas with normal karyotype as this subgroup of tumors also exhibit PLAG1 activation (PubMed:9020842, PubMed:10029085, PubMed:9525740, PubMed:16736500). {ECO:0000269 PubMed:10029085, ECO:0000269 PubMed:16736500, ECO:0000269 PubMed:9020842, ECO:0000269 PubMed:9525740}.
  • Note=A chromosomal aberration involving PLAG1 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. 8q12.1 to 8q24.1 intrachromosomal rearrangement with hyaluronic acid synthase 2/HAS2 results in promoter swapping and activation of PLAG1 expression. The breakpoint of HAS2 gene is in PLAG1 intron 1, whereas its coding sequence starts at exon 2 or exon 3. Translocation t(7;8)(p22;q13) with collagen 1A2/COL1A2. Fusion transcript COL1A2-PLAG1 as well as HAS2-PLAG1 encode a full-length PLAG1 protein. {ECO:0000269 PubMed:10987300, ECO:0000269 PubMed:15642402}.

Additional Disease Information for PLAG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLAG1: view

No data available for Genatlas for PLAG1 Gene

Publications for PLAG1 Gene

  1. CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. (PMID: 16736500) Asp J … Stenman G (Genes, chromosomes & cancer 2006) 3 4 22 58
  2. Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma. (PMID: 14695992) Zatkova A … Wimmer K (Genes, chromosomes & cancer 2004) 3 4 22 58
  3. Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation. (PMID: 15208321) Van Dyck F … Chavez MV (The Journal of biological chemistry 2004) 3 4 22 58
  4. PLAG1 fusion oncogenes in lipoblastoma. (PMID: 10987300) Hibbard MK … Fletcher JA (Cancer research 2000) 3 4 22 58
  5. PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. (PMID: 10646861) Voz ML … Kas K (Cancer research 2000) 3 4 22 58

Products for PLAG1 Gene

Sources for PLAG1 Gene

Content
Loading form....