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Aliases for SERPINI2 Gene

Aliases for SERPINI2 Gene

  • Serpin Family I Member 2 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade I (Neuroserpin), Member 2 2 3
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade I (Pancpin), Member 2 2 3
  • Serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 2 3
  • Myoepithelium-Derived Serine Protease Inhibitor 3 4
  • Pancreas-Specific Protein TSA2004 3 4
  • Peptidase Inhibitor 14 3 4
  • PANCPIN 3 4
  • PI14 3 4
  • MEPI 3 4
  • Protease Inhibitor 14 3
  • Serpin I2 3
  • TSA2004 3
  • PI-14 4

External Ids for SERPINI2 Gene

Previous HGNC Symbols for SERPINI2 Gene

  • PI14

Previous GeneCards Identifiers for SERPINI2 Gene

  • GC03M164449
  • GC03M168213
  • GC03M168561
  • GC03M168480
  • GC03M168642
  • GC03M167156

Summaries for SERPINI2 Gene

Entrez Gene Summary for SERPINI2 Gene

  • The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for SERPINI2 Gene

SERPINI2 (Serpin Family I Member 2) is a Protein Coding gene. Diseases associated with SERPINI2 include Specific Bursitis Often Of Occupational Origin and Brachial Plexus Lesion. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINI1.

Gene Wiki entry for SERPINI2 Gene

Additional gene information for SERPINI2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINI2 Gene

Genomics for SERPINI2 Gene

GeneHancer (GH) Regulatory Elements for SERPINI2 Gene

Promoters and enhancers for SERPINI2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I167474 Promoter 0.5 EPDnew 550.8 +4.9 4943 0.1 SERPINI2 LOC105374197
GH03I168090 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.1 -615.2 -615223 6.6 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GOLIM4 HMGN1P8 SERPINI2 HMGN2P26
GH03I167463 Enhancer 0.2 FANTOM5 7.5 +15.1 15062 0.2 ZBBX SERPINI2 LOC105374197 LINC01327
GH03I167520 Enhancer 0.5 FANTOM5 0.3 -42.1 -42053 0.4 POLR2A CEBPA CEBPB SERPINI2 GC03M167593 WDR49
GH03I167525 Enhancer 0.4 FANTOM5 0.2 -46.7 -46695 0.3 PRDM1 FOXA1 SERPINI2 GC03M167593 WDR49
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINI2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINI2 gene promoter:

Genomic Locations for SERPINI2 Gene

Genomic Locations for SERPINI2 Gene
37,216 bases
Minus strand

Genomic View for SERPINI2 Gene

Genes around SERPINI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINI2 Gene

Proteins for SERPINI2 Gene

  • Protein details for SERPINI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serpin I2
    Protein Accession:

    Protein attributes for SERPINI2 Gene

    405 amino acids
    Molecular mass:
    46145 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH27859.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERPINI2 Gene

Post-translational modifications for SERPINI2 Gene

  • Glycosylation at isoforms=202, isoforms=207, and isoforms=306
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINI2 Gene

No data available for DME Specific Peptides for SERPINI2 Gene

Domains & Families for SERPINI2 Gene

Gene Families for SERPINI2 Gene

Protein Domains for SERPINI2 Gene

Suggested Antigen Peptide Sequences for SERPINI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serpin family.
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINI2: view

Function for SERPINI2 Gene

Gene Ontology (GO) - Molecular Function for SERPINI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINI2: view
genes like me logo Genes that share phenotypes with SERPINI2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SERPINI2

CRISPR Products

miRNA for SERPINI2 Gene

miRTarBase miRNAs that target SERPINI2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERPINI2 Gene

Localization for SERPINI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINI2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINI2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SERPINI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IBA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with SERPINI2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINI2 Gene

Pathways & Interactions for SERPINI2 Gene

SuperPathways for SERPINI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERPINI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 10097100
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030155 regulation of cell adhesion IEA --
genes like me logo Genes that share ontologies with SERPINI2: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINI2 Gene

Drugs & Compounds for SERPINI2 Gene

No Compound Related Data Available

Transcripts for SERPINI2 Gene

Unigene Clusters for SERPINI2 Gene

Serpin peptidase inhibitor, clade I (pancpin), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINI2 Gene

No ASD Table

Relevant External Links for SERPINI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINI2 Gene

This gene is overexpressed in Pancreas (x50.5).

Protein differential expression in normal tissues from HIPED for SERPINI2 Gene

This gene is overexpressed in Pancreatic juice (32.1), Pancreas (24.8), and Fetal gut (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINI2 Gene

Protein tissue co-expression partners for SERPINI2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERPINI2 Gene:


SOURCE GeneReport for Unigene cluster for SERPINI2 Gene:


mRNA Expression by UniProt/SwissProt for SERPINI2 Gene:

Tissue specificity: Expressed in pancreas and adipose tissues.

Evidence on tissue expression from TISSUES for SERPINI2 Gene

  • Pancreas(4.6)
  • Spleen(4)
genes like me logo Genes that share expression patterns with SERPINI2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINI2 Gene

Orthologs for SERPINI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERPINI2 33 34
  • 99.42 (n)
(Canis familiaris)
Mammalia SERPINI2 33 34
  • 89.47 (n)
(Bos Taurus)
Mammalia SERPINI2 33 34
  • 88.89 (n)
(Rattus norvegicus)
Mammalia Serpini2 33
  • 83.46 (n)
(Mus musculus)
Mammalia Serpini2 33 16 34
  • 82.44 (n)
(Monodelphis domestica)
Mammalia SERPINI2 34
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia serpini2 33
  • 67.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Spn6 35 34
  • 31 (a)
Spn1 34
  • 31 (a)
Spn3 34
  • 30 (a)
Spn2 35 34
  • 29 (a)
Spn43Aa 35 34
  • 28 (a)
nec 35 34
  • 27 (a)
Spn42De 34
  • 27 (a)
Spn43Ab 35 34
  • 26 (a)
Spn28Db 34
  • 26 (a)
Spn42Db 34
  • 26 (a)
Spn28Da 34
  • 25 (a)
Spn4 34
  • 25 (a)
Spn7 34
  • 25 (a)
Spn42Dc 34
  • 24 (a)
Spn47C 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea srp-6 35
  • 31 (a)
srp-7 35
  • 31 (a)
srp-1 35
  • 26 (a)
Species where no ortholog for SERPINI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINI2 Gene

Gene Tree for SERPINI2 (if available)
Gene Tree for SERPINI2 (if available)

Paralogs for SERPINI2 Gene

Variants for SERPINI2 Gene

Sequence variations from dbSNP and Humsavar for SERPINI2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000039759 -- 167,461,265(-) C/T intron_variant
rs1000087923 -- 167,460,817(-) A/T intron_variant
rs1000148186 -- 167,454,714(-) C/G intron_variant
rs1000212167 -- 167,467,680(-) T/C intron_variant
rs1000303592 -- 167,450,600(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINI2 Gene

Variant ID Type Subtype PubMed ID
nsv592495 CNV gain 21841781

Variation tolerance for SERPINI2 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.87; 94.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINI2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINI2 Gene

Disorders for SERPINI2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SERPINI2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
specific bursitis often of occupational origin
  • specific bursitides often of occupational origin
brachial plexus lesion
  • brachial plexus lesions
olecranon bursitis
  • bursitis of elbow
ulnar neuropathy
  • ulnar neuropathy [ambiguous]
  • andrel epicondylitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINI2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SERPINI2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINI2 Gene

Publications for SERPINI2 Gene

  1. Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells. (PMID: 9624529) Ozaki K … Nakamura Y (Genes, chromosomes & cancer 1998) 2 3 4 22 58
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26. (PMID: 10992299) Chang WS … Wu FY (Genes, chromosomes & cancer 2000) 3 22 58

Products for SERPINI2 Gene

Sources for SERPINI2 Gene

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