Aliases for SERPINE2 Gene
External Ids for SERPINE2 Gene
Previous HGNC Symbols for SERPINE2 Gene
Previous GeneCards Identifiers for SERPINE2 Gene
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for SERPINE2 Gene
SERPINE2 (Serpin Family E Member 2) is a Protein Coding gene. Diseases associated with SERPINE2 include Visceral Heterotaxy and Kartagener Syndrome. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include receptor binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINE1.
UniProtKB/Swiss-Prot for SERPINE2 Gene
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.