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Aliases for SERPINB6 Gene

Aliases for SERPINB6 Gene

  • Serpin Family B Member 6 2 3 5
  • Cytoplasmic Antiproteinase 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 6 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 6 2 3
  • PI-6 3 4
  • PI6 3 4
  • CAP 3 4
  • PTI 3 4
  • Protease Inhibitor 6 (Placental Thrombin Inhibitor) 3
  • Deafness, Autosomal Recessive 91 2
  • Placental Thrombin Inhibitor 4
  • Peptidase Inhibitor 6 4
  • Serpin B6 3
  • MSTP057 3
  • DFNB91 3
  • SPI3 3

External Ids for SERPINB6 Gene

Previous HGNC Symbols for SERPINB6 Gene

  • PI6
  • DFNB91

Previous GeneCards Identifiers for SERPINB6 Gene

  • GC06M002933
  • GC06M002893
  • GC06M002821

Summaries for SERPINB6 Gene

Entrez Gene Summary for SERPINB6 Gene

  • The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for SERPINB6 Gene

SERPINB6 (Serpin Family B Member 6) is a Protein Coding gene. Diseases associated with SERPINB6 include Deafness, Autosomal Recessive 91 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Amoebiasis and Innate Immune System. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and protease binding. An important paralog of this gene is SERPINB8.

UniProtKB/Swiss-Prot for SERPINB6 Gene

  • May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.

Gene Wiki entry for SERPINB6 Gene

Additional gene information for SERPINB6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB6 Gene

Genomics for SERPINB6 Gene

GeneHancer (GH) Regulatory Elements for SERPINB6 Gene

Promoters and enhancers for SERPINB6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J002969 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 665.7 +0.9 928 2.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SERPINB6 GC06P002970 LINC01011 NQO2
GH06J002957 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 660.8 +11.4 11350 5.9 PKNOX1 FOXA2 TCF12 POLR2B ATF7 FOS CREM CEBPB NCOA1 GATAD2B SERPINB6 NQO2 LINC01011 ENSG00000232999 SERPINB9 MYLK4 GC06P002970 GC06M002954 PIR46440
GH06J002973 Enhancer 0.9 ENCODE dbSUPER 657.9 -1.7 -1707 0.2 HDAC1 TEAD4 MAX BACH1 ZKSCAN1 ZNF766 VEZF1 CBFA2T2 CREM SMARCE1 SERPINB6 ENSG00000232999 SERPINB9 GC06P002970 GC06P002979
GH06J002979 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.9 -14.0 -13955 13.6 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 NQO2 LINC01011 RIPK1 PSMG4 ENSG00000228170 WRNIP1 ENSG00000272320 LOC105374888 SERPINB9 SERPINB6
GH06J002951 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +19.7 19682 2.1 HDGF PKNOX1 SMAD1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 GC06M002954 PIR46440 SERPINB9 SERPINB6 SERPINB1 NQO2 LINC01011 ENSG00000232999 MYLK4 RIPK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERPINB6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINB6 gene promoter:
  • AP-1
  • Sp1
  • c-Jun
  • ATF-2
  • ATF
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a

Genomic Locations for SERPINB6 Gene

Genomic Locations for SERPINB6 Gene
chr6:2,948,159-2,972,165
(GRCh38/hg38)
Size:
24,007 bases
Orientation:
Minus strand
chr6:2,948,393-2,972,399
(GRCh37/hg19)
Size:
24,007 bases
Orientation:
Minus strand

Genomic View for SERPINB6 Gene

Genes around SERPINB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB6 Gene

Proteins for SERPINB6 Gene

  • Protein details for SERPINB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35237-SPB6_HUMAN
    Recommended name:
    Serpin B6
    Protein Accession:
    P35237
    Secondary Accessions:
    • B2RBA8
    • Q59F97
    • Q5TD06
    • Q7Z2Y7
    • Q96J44
    • Q9UDI7

    Protein attributes for SERPINB6 Gene

    Size:
    376 amino acids
    Molecular mass:
    42622 Da
    Quaternary structure:
    • Forms a complex with the monomeric form of beta-tryptase.
    SequenceCaution:
    • Sequence=BAD92800.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD98106.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERPINB6 Gene

Post-translational modifications for SERPINB6 Gene

  • Ubiquitination at posLast=314314 and isoforms=252
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SERPINB6 Gene

Domains & Families for SERPINB6 Gene

Gene Families for SERPINB6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERPINB6 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB6 Gene

Graphical View of Domain Structure for InterPro Entry

P35237

UniProtKB/Swiss-Prot:

SPB6_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB6: view

Function for SERPINB6 Gene

Molecular function for SERPINB6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.

Phenotypes From GWAS Catalog for SERPINB6 Gene

Gene Ontology (GO) - Molecular Function for SERPINB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 14670919
GO:0004867 serine-type endopeptidase inhibitor activity IDA 17761692
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB6: view
genes like me logo Genes that share phenotypes with SERPINB6: view

Human Phenotype Ontology for SERPINB6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SERPINB6 Gene

MGI Knock Outs for SERPINB6:

Animal Model Products

CRISPR Products

miRNA for SERPINB6 Gene

miRTarBase miRNAs that target SERPINB6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SERPINB6 Gene

Localization for SERPINB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 3
nucleus 3
endoplasmic reticulum 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SERPINB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 27068509
GO:0005615 extracellular space IEA,IBA --
GO:0005634 NOT nucleus IDA 14670919
GO:0005737 cytoplasm IEA,IDA 14670919
GO:0005829 cytosol TAS 8415716
genes like me logo Genes that share ontologies with SERPINB6: view

Pathways & Interactions for SERPINB6 Gene

genes like me logo Genes that share pathways with SERPINB6: view

Pathways by source for SERPINB6 Gene

1 BioSystems pathway for SERPINB6 Gene
1 KEGG pathway for SERPINB6 Gene

Gene Ontology (GO) - Biological Process for SERPINB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IMP 20451170
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IDA 17761692
GO:0043312 neutrophil degranulation TAS --
GO:0071470 cellular response to osmotic stress IMP 20451170
genes like me logo Genes that share ontologies with SERPINB6: view

No data available for SIGNOR curated interactions for SERPINB6 Gene

Drugs & Compounds for SERPINB6 Gene

(2) Drugs for SERPINB6 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Drotrecogin alfa Approved, Investigational, Withdrawn Pharma Target 0

(1) Additional Compounds for SERPINB6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB6: view

Transcripts for SERPINB6 Gene

Unigene Clusters for SERPINB6 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: -
SP10: - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - -
SP14: -
SP15: - - - - - - - - - - -
SP16:
SP17: - - - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - -

ExUns: 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15a · 15b · 15c · 15d
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8: -
SP9: -
SP10: -
SP11: -
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for SERPINB6 Gene

GeneLoc Exon Structure for
SERPINB6
ECgene alternative splicing isoforms for
SERPINB6

Expression for SERPINB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINB6 Gene

Protein differential expression in normal tissues from HIPED for SERPINB6 Gene

This gene is overexpressed in Pancreatic juice (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SERPINB6 Gene



Protein tissue co-expression partners for SERPINB6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERPINB6 Gene:

SERPINB6

SOURCE GeneReport for Unigene cluster for SERPINB6 Gene:

Hs.519523

mRNA Expression by UniProt/SwissProt for SERPINB6 Gene:

P35237-SPB6_HUMAN
Tissue specificity: Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.

Evidence on tissue expression from TISSUES for SERPINB6 Gene

  • Nervous system(4.9)
  • Intestine(4.7)
  • Liver(4.6)
  • Lung(4)
  • Muscle(4)
  • Pancreas(3.1)
  • Eye(2.8)
  • Skin(2.8)
  • Kidney(2.6)
  • Stomach(2.6)
  • Heart(2.5)
  • Spleen(2.5)
  • Adrenal gland(2.4)
  • Blood(2.3)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB6 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • head
  • inner ear
  • middle ear
  • outer ear
  • skull
General:
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with SERPINB6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SERPINB6 Gene

Orthologs for SERPINB6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB6 34 33
  • 97.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINB6 34 33
  • 80.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb6a 16 34 33
  • 79.43 (n)
Serpinb6b 34
  • 72 (a)
OneToMany
Serpinb6c 34
  • 68 (a)
OneToMany
Serpinb6d 34
  • 59 (a)
OneToMany
Serpinb6e 34
  • 51 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Serpinb6 33
  • 78.9 (n)
cow
(Bos Taurus)
Mammalia LOC617406 33
  • 77.66 (n)
-- 34
  • 76 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves SERPINB6 33
  • 67.2 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia serpinb6 33
  • 62.91 (n)
zebrafish
(Danio rerio)
Actinopterygii serpinb1l4 33
  • 61.11 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11177 33
fruit fly
(Drosophila melanogaster)
Insecta Spn6 35
  • 34 (a)
Spn1 35
  • 33 (a)
Spn3 35
  • 33 (a)
Spn43Aa 35
  • 33 (a)
CG9455 35
  • 32 (a)
Spn2 35
  • 32 (a)
nec 35
  • 30 (a)
CG9460 35
  • 30 (a)
CG6687 35
  • 29 (a)
CG6717 35
  • 29 (a)
Spn5 35
  • 29 (a)
Spn43Ab 35
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-6 35
  • 30 (a)
srp-7 35
  • 30 (a)
srp-1 35
  • 28 (a)
Species where no ortholog for SERPINB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERPINB6 Gene

ENSEMBL:
Gene Tree for SERPINB6 (if available)
TreeFam:
Gene Tree for SERPINB6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERPINB6: view image

Paralogs for SERPINB6 Gene

Variants for SERPINB6 Gene

Sequence variations from dbSNP and Humsavar for SERPINB6 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs267607037 pathogenic, Deafness, autosomal recessive 91 2,948,696(-) C/A coding_sequence_variant, stop_gained
rs144895010 likely-benign, not specified 2,948,935(-) G/A coding_sequence_variant, synonymous_variant
rs145397970 likely-benign, not specified 2,948,334(-) G/A coding_sequence_variant, synonymous_variant
rs145538358 likely-benign, not specified 2,959,233(-) T/C coding_sequence_variant, intron_variant, missense_variant
rs146252067 likely-benign, not specified 2,954,643(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB6 Gene

Variant ID Type Subtype PubMed ID
nsv1018369 CNV loss 25217958
nsv1145088 CNV deletion 24896259
nsv437477 CNV loss 16327808
nsv600832 CNV loss 21841781
nsv600833 CNV loss 21841781
nsv830575 CNV loss 17160897
nsv950760 CNV deletion 24416366
nsv956956 CNV deletion 24416366

Variation tolerance for SERPINB6 Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINB6 Gene

Human Gene Mutation Database (HGMD)
SERPINB6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB6 Gene

Disorders for SERPINB6 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SERPINB6 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 91
  • dfnb91
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
sensorineural hearing loss
  • central hearing loss
diffuse cutaneous mastocytosis
  • dcm
gnathomiasis
  • gnathostomiasis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SPB6_HUMAN
  • Deafness, autosomal recessive, 91 (DFNB91) [MIM:613453]: A form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal. {ECO:0000269 PubMed:20451170}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SERPINB6

genes like me logo Genes that share disorders with SERPINB6: view

No data available for Genatlas for SERPINB6 Gene

Publications for SERPINB6 Gene

  1. Cloning and molecular characterization of a human intracellular serine proteinase inhibitor. (PMID: 8415716) Coughlin P … Bird P (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 22 58
  2. A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. (PMID: 20451170) Sirmaci A … Tekin M (American journal of human genetics 2010) 2 3 4 58
  3. SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. (PMID: 17761692) Scott FL … Bird PI (Journal of biochemistry 2007) 3 4 22 58
  4. Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. (PMID: 14670919) Strik MC … Kummer JA (Blood 2004) 3 4 22 58
  5. A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. (PMID: 9858835) Sun J … Bird PI (Cytogenetics and cell genetics 1998) 2 3 22 58

Products for SERPINB6 Gene

Sources for SERPINB6 Gene

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