Aliases for PGK2 Gene
External Ids for PGK2 Gene
Previous GeneCards Identifiers for PGK2 Gene
This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]
GeneCards Summary for PGK2 Gene
PGK2 (Phosphoglycerate Kinase 2) is a Protein Coding gene. Diseases associated with PGK2 include Male Reproductive System Disease. Among its related pathways are Cori Cycle and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphoglycerate kinase activity. An important paralog of this gene is PGK1.
UniProtKB/Swiss-Prot for PGK2 Gene
Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity).