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Aliases for ATP5PF Gene

Aliases for ATP5PF Gene

  • ATP Synthase Peripheral Stalk Subunit F6 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit F6 2 3 5
  • ATP5J 3 4 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit F6 2 3
  • Coupling Factor 6 2 3
  • ATPase Subunit F6 3 4
  • ATP5A 3 4
  • ATPM 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit F6 2
  • ATP Synthase-Coupling Factor 6, Mitochondrial 3
  • Mitochondrial ATP Synthase, Coupling Factor 6 3
  • Mitochondrial ATP Synthase, Subunit F6 3
  • Mitochondrial ATPase Coupling Factor 6 3
  • Proliferation-Inducing Protein 36 3
  • ATP5 3
  • CF6 3
  • F6 3

External Ids for ATP5PF Gene

Previous HGNC Symbols for ATP5PF Gene

  • ATP5A
  • ATP5
  • ATPM
  • ATP5J

Summaries for ATP5PF Gene

Entrez Gene Summary for ATP5PF Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo complex has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex. The F6 subunit is required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has 1 or more pseudogenes. [provided by RefSeq, Feb 2016]

GeneCards Summary for ATP5PF Gene

ATP5PF (ATP Synthase Peripheral Stalk Subunit F6) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism.

UniProtKB/Swiss-Prot for ATP5PF Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.

Gene Wiki entry for ATP5PF Gene

Additional gene information for ATP5PF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5PF Gene

Genomics for ATP5PF Gene

GeneHancer (GH) Regulatory Elements for ATP5PF Gene

Promoters and enhancers for ATP5PF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I025732 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 557 +0.5 474 5.5 CLOCK ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ATP5PF GABPA PIR60960 MRPL39
GH21I025638 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 10.5 +96.0 95994 2.6 RB1 ZNF76 ZNF335 GLIS2 ZNF366 ZNF143 BCLAF1 EGR2 SMARCA5 SP3 JAM2 MRPL39 GABPA ATP5PF RNGTTP1
GH21I025966 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -232.2 -232184 2.5 JUNB ELF1 NR2F2 SPI1 ENSG00000233783 RNU6-123P APP ENSG00000224541 ATP5PF GABPA GC21P025992
GH21I025789 Enhancer 1 Ensembl ENCODE 10.8 -54.7 -54691 1.3 FOXA2 MZF1 ZBTB40 RAD21 YY1 ARID2 ZNF143 FOS EGR2 ZNF654 ATP5PF GABPA PIR41801 LOC105372757
GH21I026070 Enhancer 0.9 Ensembl ENCODE 9.2 -335.6 -335603 2.5 FOXA2 USF1 ZNF366 ZSCAN5C KLF8 SP3 ZNF189 ZNF518A NR2F2 OSR2 GABPA APP ENSG00000224541 ENSG00000233783 ATP5PF GC21P025992
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATP5PF on UCSC Golden Path with GeneCards custom track

Genomic Locations for ATP5PF Gene

Genomic Locations for ATP5PF Gene
chr21:25,716,503-25,735,673
(GRCh38/hg38)
Size:
19,171 bases
Orientation:
Minus strand
chr21:27,088,815-27,107,984
(GRCh37/hg19)

Genomic View for ATP5PF Gene

Genes around ATP5PF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5PF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5PF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5PF Gene

Proteins for ATP5PF Gene

  • Protein details for ATP5PF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18859-ATP5J_HUMAN
    Recommended name:
    ATP synthase-coupling factor 6, mitochondrial
    Protein Accession:
    P18859
    Secondary Accessions:
    • J3KQ83

    Protein attributes for ATP5PF Gene

    Size:
    108 amino acids
    Molecular mass:
    12588 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

    Alternative splice isoforms for ATP5PF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP5PF Gene

Post-translational modifications for ATP5PF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATP5PF Gene

Domains & Families for ATP5PF Gene

Gene Families for ATP5PF Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ATP5PF Gene

Graphical View of Domain Structure for InterPro Entry

P18859

UniProtKB/Swiss-Prot:

ATP5J_HUMAN :
  • Belongs to the eukaryotic ATPase subunit F6 family.
Family:
  • Belongs to the eukaryotic ATPase subunit F6 family.
genes like me logo Genes that share domains with ATP5PF: view

Function for ATP5PF Gene

Molecular function for ATP5PF Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.

Gene Ontology (GO) - Molecular Function for ATP5PF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity NAS 1830479
GO:0015078 hydrogen ion transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
genes like me logo Genes that share ontologies with ATP5PF: view
genes like me logo Genes that share phenotypes with ATP5PF: view

Animal Model Products

CRISPR Products

miRNA for ATP5PF Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5PF Gene

Localization for ATP5PF Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5PF Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5PF gene
Compartment Confidence
mitochondrion 5
cytosol 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATP5PF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
GO:0005739 mitochondrion TAS,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP5PF: view

Pathways & Interactions for ATP5PF Gene

genes like me logo Genes that share pathways with ATP5PF: view

Gene Ontology (GO) - Biological Process for ATP5PF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IEA --
GO:0015992 proton transport IEA --
genes like me logo Genes that share ontologies with ATP5PF: view

No data available for SIGNOR curated interactions for ATP5PF Gene

Drugs & Compounds for ATP5PF Gene

No Compound Related Data Available

Transcripts for ATP5PF Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5PF Gene

No ASD Table

Relevant External Links for ATP5PF Gene

GeneLoc Exon Structure for
ATP5PF
ECgene alternative splicing isoforms for
ATP5PF

Expression for ATP5PF Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP5PF Gene:

ATP5PF

Evidence on tissue expression from TISSUES for ATP5PF Gene

  • Liver(4.7)
  • Kidney(4.5)
  • Eye(4.3)
  • Heart(3.6)
  • Nervous system(3.6)
  • Muscle(3.3)
  • Intestine(2.5)
  • Blood(2.4)
  • Adrenal gland(2.2)
  • Spleen(2.1)
  • Stomach(2.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5PF Gene

Orthologs for ATP5PF Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP5PF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5J 34 33
  • 98.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5J 33 34
  • 89.37 (n)
mouse
(Mus musculus)
Mammalia Atp5j 16 34 33
  • 88.27 (n)
rat
(Rattus norvegicus)
Mammalia Atp5j 33
  • 86.42 (n)
cow
(Bos Taurus)
Mammalia ATP5J 33 34
  • 85.19 (n)
oppossum
(Monodelphis domestica)
Mammalia ATP5J 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5J 34 33
  • 66.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5J 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5j 33
  • 72.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68738 33
zebrafish
(Danio rerio)
Actinopterygii atp5j 34 33
  • 60.61 (n)
OneToMany
ATP5J (2 of 4) 34
  • 9 (a)
OneToMany
ATP5J (3 of 4) 34
  • 9 (a)
OneToMany
ATP5J (4 of 4) 34
  • 9 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-Cf6 34
  • 42 (a)
OneToMany
CG12027 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5066 34
  • 35 (a)
OneToOne
Species where no ortholog for ATP5PF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5PF Gene

ENSEMBL:
Gene Tree for ATP5PF (if available)
TreeFam:
Gene Tree for ATP5PF (if available)

Paralogs for ATP5PF Gene

Pseudogenes.org Pseudogenes for ATP5PF Gene

genes like me logo Genes that share paralogs with ATP5PF: view

No data available for Paralogs for ATP5PF Gene

Variants for ATP5PF Gene

Sequence variations from dbSNP and Humsavar for ATP5PF Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000273514 -- 25,734,541(-) A/T 5_prime_UTR_variant, intron_variant
rs1001226740 -- 25,733,666(-) C/T intron_variant
rs1001294759 -- 25,730,124(-) C/T intron_variant
rs1001346748 -- 25,730,396(-) A/G intron_variant
rs1001407924 -- 25,726,937(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5PF Gene

Variant ID Type Subtype PubMed ID
esv3646715 CNV loss 21293372
nsv1064561 CNV loss 25217958

Variation tolerance for ATP5PF Gene

Residual Variation Intolerance Score: 62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP5PF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5PF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5PF Gene

Disorders for ATP5PF Gene

Additional Disease Information for ATP5PF

No disorders were found for ATP5PF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5PF Gene

Publications for ATP5PF Gene

  1. Human mitochondrial ATP synthase: cloning cDNA for the nuclear-encoded precursor of coupling factor 6. (PMID: 1825642) Javed AA … Sanadi DR (Gene 1991) 2 3 4 58
  2. Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria. (PMID: 1830479) Higuti T … Ichihara A (Biochemical and biophysical research communications 1991) 2 3 4 58
  3. Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule. (PMID: 18243211) Kumagai A … Okumura K (Atherosclerosis 2008) 3 22 58
  4. Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor. (PMID: 16230521) Osanai T … Okumura K (Hypertension (Dallas, Tex. : 1979) 2005) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ATP5PF Gene

Sources for ATP5PF Gene

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