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Aliases for PFDN5 Gene

Aliases for PFDN5 Gene

  • Prefoldin Subunit 5 2 3 3 5
  • PFD5 3 4
  • MM1 3 4
  • C-Myc-Binding Protein Mm-1 4
  • C-Myc Binding Protein 3
  • Myc Modulator-1 3
  • Myc Modulator 1 4
  • Prefoldin 5 2
  • MM-1 3

External Ids for PFDN5 Gene

Previous GeneCards Identifiers for PFDN5 Gene

  • GC12M054016
  • GC12M053811
  • GC12P053406
  • GC12P051975
  • GC12P053689
  • GC12P050730

Summaries for PFDN5 Gene

Entrez Gene Summary for PFDN5 Gene

  • This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PFDN5 Gene

PFDN5 (Prefoldin Subunit 5) is a Protein Coding gene. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and unfolded protein binding.

UniProtKB/Swiss-Prot for PFDN5 Gene

  • Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.

Gene Wiki entry for PFDN5 Gene

Additional gene information for PFDN5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PFDN5 Gene

Genomics for PFDN5 Gene

GeneHancer (GH) Regulatory Elements for PFDN5 Gene

Promoters and enhancers for PFDN5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J053294 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.4 2388 6.5 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 ZNF610 PFDN5 PIR39957 PIR44034 C12orf10 ESPL1 AAAS ZNF740 ENSG00000257605 LOC105378250 ENSG00000257500
GH12J053060 Enhancer 1.4 Ensembl ENCODE dbSUPER 33.8 -228.4 -228362 13.5 HDGF PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZNF2 AAAS PCBP2 ZNF740 ATF7 SP1 PFDN5 LOC100652999 EIF4B CALCOCO1 LOC283335
GH12J054009 Promoter/Enhancer 3.2 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 +726.8 726805 25.8 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B CBX5 HOXC8 HOXC4 HOXC6 HOXC5 GC12P054078 PIR46464 PIR59985 PIR53546 PIR59725 GC12P054102
GH12J052894 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 13.4 -392.4 -392363 16.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GC12M052900 AAAS ZNF740 PCBP2 SP1 MAP3K12 LOC100652999 ATF7 EIF4B ENSG00000257808
GH12J053971 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 +695.0 694952 36.8 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 NFYC HOXC8 HOXC5 HOXC11 HOXC9 HOXC6 HOXC10 MIR196A2 GC12P054063 GC12P054010 HNRNPA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PFDN5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PFDN5 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • ATF-2

Genomic Locations for PFDN5 Gene

Genomic Locations for PFDN5 Gene
chr12:53,295,291-53,299,450
(GRCh38/hg38)
Size:
4,160 bases
Orientation:
Plus strand
chr12:53,689,075-53,693,234
(GRCh37/hg19)
Size:
4,160 bases
Orientation:
Plus strand

Genomic View for PFDN5 Gene

Genes around PFDN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PFDN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PFDN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PFDN5 Gene

Proteins for PFDN5 Gene

  • Protein details for PFDN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99471-PFD5_HUMAN
    Recommended name:
    Prefoldin subunit 5
    Protein Accession:
    Q99471
    Secondary Accessions:
    • A8K9A8
    • Q54AA8
    • Q9C083
    • Q9C084

    Protein attributes for PFDN5 Gene

    Size:
    154 amino acids
    Molecular mass:
    17328 Da
    Quaternary structure:
    • Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to MYC; interacts with its N-terminal domain.
    SequenceCaution:
    • Sequence=BAA14006.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PFDN5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PFDN5 Gene

Post-translational modifications for PFDN5 Gene

  • Ubiquitination at Lys153 and Lys112
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PFDN5 Gene

Domains & Families for PFDN5 Gene

Gene Families for PFDN5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PFDN5 Gene

Suggested Antigen Peptide Sequences for PFDN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99471

UniProtKB/Swiss-Prot:

PFD5_HUMAN :
  • Belongs to the prefoldin subunit alpha family.
Family:
  • Belongs to the prefoldin subunit alpha family.
genes like me logo Genes that share domains with PFDN5: view

Function for PFDN5 Gene

Molecular function for PFDN5 Gene

UniProtKB/Swiss-Prot Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.

Phenotypes From GWAS Catalog for PFDN5 Gene

Gene Ontology (GO) - Molecular Function for PFDN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS 9792694
GO:0005515 protein binding IPI 17728244
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with PFDN5: view
genes like me logo Genes that share phenotypes with PFDN5: view

Animal Model Products

miRNA for PFDN5 Gene

miRTarBase miRNAs that target PFDN5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PFDN5 Gene

Localization for PFDN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PFDN5 Gene

Isoform 1: Nucleus.
Isoform 2: Cytoplasm.
Isoform 3: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PFDN5 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for PFDN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA --
GO:0005737 cytoplasm TAS 16130169
GO:0016272 prefoldin complex IBA,IEA --
genes like me logo Genes that share ontologies with PFDN5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PFDN5 Gene

Pathways & Interactions for PFDN5 Gene

genes like me logo Genes that share pathways with PFDN5: view

Gene Ontology (GO) - Biological Process for PFDN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 9792694
GO:0006457 protein folding IEA --
GO:0045892 negative regulation of transcription, DNA-templated IMP 18281035
GO:0060041 retina development in camera-type eye IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IMP 18281035
genes like me logo Genes that share ontologies with PFDN5: view

No data available for SIGNOR curated interactions for PFDN5 Gene

Drugs & Compounds for PFDN5 Gene

No Compound Related Data Available

Transcripts for PFDN5 Gene

mRNA/cDNA for PFDN5 Gene

Unigene Clusters for PFDN5 Gene

Prefoldin subunit 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PFDN5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - -
SP12:

Relevant External Links for PFDN5 Gene

GeneLoc Exon Structure for
PFDN5
ECgene alternative splicing isoforms for
PFDN5

Expression for PFDN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PFDN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PFDN5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PFDN5 Gene



Protein tissue co-expression partners for PFDN5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PFDN5 Gene:

PFDN5

SOURCE GeneReport for Unigene cluster for PFDN5 Gene:

Hs.655327

mRNA Expression by UniProt/SwissProt for PFDN5 Gene:

Q99471-PFD5_HUMAN
Tissue specificity: Highly expressed in pancreas and skeletal muscle and moderately in other tissues.

Evidence on tissue expression from TISSUES for PFDN5 Gene

  • Nervous system(4.7)
  • Blood(4.5)
  • Lung(3.1)
  • Thyroid gland(2.9)
  • Liver(2.7)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Adrenal gland(2.5)
  • Spleen(2.5)
  • Gall bladder(2.4)
  • Heart(2.4)
  • Intestine(2.4)
  • Kidney(2.4)
  • Muscle(2.4)
  • Skin(2.3)
  • Stomach(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with PFDN5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PFDN5 Gene

Orthologs for PFDN5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PFDN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PFDN5 34 33
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PFDN5 34 33
  • 93.07 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pfdn5 33
  • 92.86 (n)
dog
(Canis familiaris)
Mammalia PFDN5 34 33
  • 92.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pfdn5 16 34 33
  • 91.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PFDN5 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859376 33
  • 80.3 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia pfdn5 33
  • 75 (n)
Str.6506 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24330 33
zebrafish
(Danio rerio)
Actinopterygii pfdn5 34 33
  • 72.63 (n)
OneToOne
wufa09c11 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003416 33
  • 53.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7048 34 33
  • 51 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pfd-5 34
  • 28 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL352C 33
  • 51.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIM5 36 34 33
  • 50.95 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10329g 33
  • 49.33 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PFD5 33
  • 48.64 (n)
rice
(Oryza sativa)
Liliopsida Os10g0488100 33
  • 59.32 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02963 33
  • 52.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bob1 33
  • 50.12 (n)
Species where no ortholog for PFDN5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PFDN5 Gene

ENSEMBL:
Gene Tree for PFDN5 (if available)
TreeFam:
Gene Tree for PFDN5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PFDN5: view image

Paralogs for PFDN5 Gene

Pseudogenes.org Pseudogenes for PFDN5 Gene

genes like me logo Genes that share paralogs with PFDN5: view

No data available for Paralogs for PFDN5 Gene

Variants for PFDN5 Gene

Sequence variations from dbSNP and Humsavar for PFDN5 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000658582 -- 53,299,549(+) T/C downstream_transcript_variant
rs1000872246 -- 53,297,837(+) T/C intron_variant
rs1001310089 -- 53,294,360(+) C/T upstream_transcript_variant
rs1001886505 -- 53,293,652(+) A/T upstream_transcript_variant
rs1002146273 -- 53,299,013(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PFDN5 Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV loss 19592680

Variation tolerance for PFDN5 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PFDN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PFDN5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PFDN5 Gene

Disorders for PFDN5 Gene

Additional Disease Information for PFDN5

No disorders were found for PFDN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PFDN5 Gene

Publications for PFDN5 Gene

  1. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. (PMID: 9630229) Vainberg IE … Cowan NJ (Cell 1998) 2 3 4 58
  2. MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc. (PMID: 9792694) Mori K … Ariga H (The Journal of biological chemistry 1998) 2 3 4 58
  3. Distinct localizations and repression activities of MM-1 isoforms toward c-Myc. (PMID: 16173081) Hagio Y … Ariga H (Journal of cellular biochemistry 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PFDN5 Gene

Sources for PFDN5 Gene

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