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Aliases for CALML5 Gene

Aliases for CALML5 Gene

  • Calmodulin Like 5 2 3 5
  • Calmodulin-Like Skin Protein 2 3 4
  • CLSP 3 4
  • Calmodulin-Like Protein 5 3
  • Calmodulin-Like 5 2

External Ids for CALML5 Gene

Previous GeneCards Identifiers for CALML5 Gene

  • GC10M005494
  • GC10M005530

Summaries for CALML5 Gene

Entrez Gene Summary for CALML5 Gene

  • This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for CALML5 Gene

CALML5 (Calmodulin Like 5) is a Protein Coding gene. Diseases associated with CALML5 include Alzheimer Disease. Among its related pathways are Apelin signaling pathway and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CALM3.

UniProtKB/Swiss-Prot for CALML5 Gene

  • Binds calcium. May be involved in terminal differentiation of keratinocytes.

Gene Wiki entry for CALML5 Gene

Additional gene information for CALML5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALML5 Gene

Genomics for CALML5 Gene

GeneHancer (GH) Regulatory Elements for CALML5 Gene

Promoters and enhancers for CALML5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J005500 Enhancer 0.4 dbSUPER 658.5 -1.4 -1350 1.1 ZNF341 SMAD4 RAD21 CALML5 CALML3 ENSG00000256462 CALML3-AS1
GH10J005444 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.4 +51.6 51637 7 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 NET1 LOC105376384 NRBF2P5 FAM208B TUBAL3 GDI2 FBH1 RBM17 CALML5 CALML3
GH10J005476 Enhancer 1.1 ENCODE dbSUPER 19 +20.7 20737 5.1 HDGF PKNOX1 SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 ATF7 CALML5 CALML3-AS1 CALML3 ENSG00000256462 ASB13 TUBAL3 NET1
GH10J005543 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -50.2 -50160 11.7 CLOCK FEZF1 DMAP1 YY1 E2F8 ZNF143 MCM3 SP3 MEF2D SSRP1 FAM208B FBH1 LOC105376384 CALML3-AS1 ENSG00000226647 CALML3 NRBF2P5 ENSG00000256462 GDI2 CALML5
GH10J005582 Enhancer 1.5 VISTA Ensembl ENCODE dbSUPER 11.6 -87.5 -87504 9.8 PKNOX1 FOXA2 ZFP64 SIN3A ZBTB7B IRF4 ZNF48 FOS RUNX3 JUNB FBH1 FAM208B LOC105376384 ENSG00000226647 CALML5 CALML3 CALML3-AS1 ENSG00000256462 LOC105376382 NET1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALML5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CALML5 gene promoter:
  • CUTL1
  • HSF2
  • GATA-2
  • LCR-F1
  • STAT5A
  • p53
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • POU2F1a

Genomic Locations for CALML5 Gene

Genomic Locations for CALML5 Gene
876 bases
Minus strand
876 bases
Minus strand

Genomic View for CALML5 Gene

Genes around CALML5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALML5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALML5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML5 Gene

Proteins for CALML5 Gene

  • Protein details for CALML5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calmodulin-like protein 5
    Protein Accession:
    Secondary Accessions:
    • Q5SQI3
    • Q8IXU8

    Protein attributes for CALML5 Gene

    146 amino acids
    Molecular mass:
    15893 Da
    Quaternary structure:
    • Associates with transglutaminase 3.

    Three dimensional structures from OCA and Proteopedia for CALML5 Gene

neXtProt entry for CALML5 Gene

Post-translational modifications for CALML5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALML5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALML5 Gene

Domains & Families for CALML5 Gene

Gene Families for CALML5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CALML5 Gene

Suggested Antigen Peptide Sequences for CALML5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CALML5: view

No data available for UniProtKB/Swiss-Prot for CALML5 Gene

Function for CALML5 Gene

Molecular function for CALML5 Gene

UniProtKB/Swiss-Prot Function:
Binds calcium. May be involved in terminal differentiation of keratinocytes.

Phenotypes From GWAS Catalog for CALML5 Gene

Gene Ontology (GO) - Molecular Function for CALML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CALML5: view
genes like me logo Genes that share phenotypes with CALML5: view

Animal Model Products

CRISPR Products

miRNA for CALML5 Gene

miRTarBase miRNAs that target CALML5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALML5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALML5 Gene

Localization for CALML5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALML5 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CALML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0070062 extracellular exosome HDA --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with CALML5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CALML5 Gene

Pathways & Interactions for CALML5 Gene

genes like me logo Genes that share pathways with CALML5: view

Gene Ontology (GO) - Biological Process for CALML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10777582
GO:0008544 epidermis development TAS 10777582
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with CALML5: view

No data available for SIGNOR curated interactions for CALML5 Gene

Drugs & Compounds for CALML5 Gene

(1) Drugs for CALML5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CALML5: view

Transcripts for CALML5 Gene

mRNA/cDNA for CALML5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALML5 Gene

Calmodulin-like 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALML5

Alternative Splicing Database (ASD) splice patterns (SP) for CALML5 Gene

No ASD Table

Relevant External Links for CALML5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALML5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALML5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALML5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x26.1) and Skin - Not Sun Exposed (Suprapubic) (x20.8).

Protein differential expression in normal tissues from HIPED for CALML5 Gene

This gene is overexpressed in Salivary gland (15.9), Skin (11.7), Cervix (11.1), and Urinary Bladder (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CALML5 Gene

NURSA nuclear receptor signaling pathways regulating expression of CALML5 Gene:


SOURCE GeneReport for Unigene cluster for CALML5 Gene:


mRNA Expression by UniProt/SwissProt for CALML5 Gene:

Tissue specificity: Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.

Evidence on tissue expression from TISSUES for CALML5 Gene

  • Skin(4.6)
  • Liver(4)
genes like me logo Genes that share expression patterns with CALML5: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALML5 Gene

Orthologs for CALML5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CALML5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CALML5 34 33
  • 98.17 (n)
(Canis familiaris)
Mammalia CALML5 34 33
  • 76.48 (n)
(Bos Taurus)
Mammalia CALML5 34 33
  • 72.41 (n)
(Rattus norvegicus)
Mammalia Calml5 33
  • 64.84 (n)
(Mus musculus)
Mammalia Calm4 16 33
  • 63.85 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia CALML5 34
  • 44 (a)
(Danio rerio)
Actinopterygii tnnc1b 34
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31960 34
  • 39 (a)
CG11165 34
  • 35 (a)
CG31958 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea cal-2 34
  • 36 (a)
cal-1 34
  • 36 (a)
cal-4 34
  • 25 (a)
cal-3 34
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMD1 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7047 34
  • 34 (a)
Species where no ortholog for CALML5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CALML5 Gene

Gene Tree for CALML5 (if available)
Gene Tree for CALML5 (if available)
Evolutionary constrained regions (ECRs) for CALML5: view image

Paralogs for CALML5 Gene

Paralogs for CALML5 Gene

(24) SIMAP similar genes for CALML5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALML5: view

Variants for CALML5 Gene

Sequence variations from dbSNP and Humsavar for CALML5 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000383189 -- 5,498,229(-) T/C downstream_transcript_variant
rs1002547499 -- 5,501,370(-) G/A upstream_transcript_variant
rs1003393037 -- 5,500,504(-) G/T upstream_transcript_variant
rs1005882780 -- 5,501,322(-) A/G upstream_transcript_variant
rs1007454349 -- 5,500,423(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CALML5 Gene

Variant ID Type Subtype PubMed ID
nsv1051283 CNV gain 25217958
nsv549886 CNV loss 21841781
nsv831774 CNV gain 17160897

Variation tolerance for CALML5 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALML5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALML5 Gene

Disorders for CALML5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CALML5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CALML5

genes like me logo Genes that share disorders with CALML5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALML5 Gene

Publications for CALML5 Gene

  1. Identification and cloning of a new calmodulin-like protein from human epidermis. (PMID: 10777582) Méhul B … Schmidt R (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. A structural and dynamic characterization of the EF-hand protein CLSP. (PMID: 16765896) Babini E … Luchinat C (Structure (London, England : 1993) 2006) 3 4 22 58
  3. Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis. (PMID: 16689864) Méhul B … Schmidt R (Experimental dermatology 2006) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CALML5 Gene

Sources for CALML5 Gene

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