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Aliases for DNAJB11 Gene

Aliases for DNAJB11 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B11 2 3 5
  • Endoplasmic Reticulum DNA J Domain-Containing Protein 3 3 4
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 11 2 3
  • ER-Associated Hsp40 Co-Chaperone 3 4
  • PWP1-Interacting Protein 4 3 4
  • APOBEC1-Binding Protein 2 3 4
  • ER-Resident Protein ERdj3 3 4
  • ABBP-2 3 4
  • ERdj3 3 4
  • ERj3p 3 4
  • EDJ 3 4
  • DnaJ Homolog Subfamily B Member 11 3
  • ER-Associated DNAJ Protein 3 3
  • DnaJ Protein Homolog 9 4
  • Human DnaJ Protein 9 4
  • ER-Associated DNAJ 4
  • DnaJ Protein 9 3
  • PRO1080 3
  • UNQ537 3
  • ABBP2 3
  • HDj-9 4
  • Dj-9 3
  • ERj3 3
  • ERJ3 4
  • HDJ9 4
  • HEDJ 4
  • DJ9 3

External Ids for DNAJB11 Gene

Previous GeneCards Identifiers for DNAJB11 Gene

  • GC03P183060
  • GC03P187545
  • GC03P187687
  • GC03P187606
  • GC03P187609
  • GC03P187767
  • GC03P186285
  • GC03P183697

Summaries for DNAJB11 Gene

Entrez Gene Summary for DNAJB11 Gene

  • This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]

GeneCards Summary for DNAJB11 Gene

DNAJB11 (DnaJ Heat Shock Protein Family (Hsp40) Member B11) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Photodynamic therapy-induced unfolded protein response. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is ENSG00000283149.

UniProtKB/Swiss-Prot for DNAJB11 Gene

  • Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.

Gene Wiki entry for DNAJB11 Gene

Additional gene information for DNAJB11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB11 Gene

Genomics for DNAJB11 Gene

GeneHancer (GH) Regulatory Elements for DNAJB11 Gene

Promoters and enhancers for DNAJB11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J186570 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +3.3 3293 2.3 HNRNPUL1 PKNOX1 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 TBCCD1 DNAJB11 TRA2B SNORA63B SNORA4 SNORA81 RFC4 RPS20P14 SNORA63 CRYGS
GH03J186566 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 0.0 -8 2.3 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 NFYC ZHX2 TBCCD1 DNAJB11 TRA2B RFC4 SNORA4 SNORA63B PIR33054
GH03J186585 Promoter 0.5 EPDnew 650.4 +17.9 17947 0.1 DNAJB11 AHSG ENSG00000283149 LOC100287402 LOC105374258
GH03J186584 Promoter 0.5 EPDnew 650.4 +17.2 17169 0.1 DNAJB11 AHSG KNG1 ENSG00000283149 LOC100287402 LOC105374258
GH03J186569 Enhancer 0.3 Ensembl 650.7 +1.7 1698 0.2 ZNF335 TBCCD1 DNAJB11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJB11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJB11 gene promoter:
  • Evi-1
  • POU2F1a
  • POU2F1
  • RP58
  • AhR
  • Arnt
  • CBF-C
  • CBF-B
  • CBF-A
  • CBF(2)

Genomic Locations for DNAJB11 Gene

Genomic Locations for DNAJB11 Gene
chr3:186,567,403-186,585,800
(GRCh38/hg38)
Size:
18,398 bases
Orientation:
Plus strand
chr3:186,285,192-186,315,061
(GRCh37/hg19)
Size:
29,870 bases
Orientation:
Plus strand

Genomic View for DNAJB11 Gene

Genes around DNAJB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB11 Gene

Proteins for DNAJB11 Gene

  • Protein details for DNAJB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBS4-DJB11_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 11
    Protein Accession:
    Q9UBS4
    Secondary Accessions:
    • Q542Y5
    • Q542Y9
    • Q6IAQ8
    • Q96JC6

    Protein attributes for DNAJB11 Gene

    Size:
    358 amino acids
    Molecular mass:
    40514 Da
    Quaternary structure:
    • Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Binds to denatured substrates in an ATP-independent manner. Interacts via the J domain with HSPA5 in an ATP-dependent manner.

neXtProt entry for DNAJB11 Gene

Post-translational modifications for DNAJB11 Gene

  • Contains high-mannose Endo H-sensitive carbohydrates.
  • Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys is not known.
  • Thr-188 was reported to be phosphorylated upon DNA damage by ATM or ATR; however as this position has been shown to be in the ER lumen, the in vivo relevance is not proven.
  • Glycosylation at Asn261
  • Ubiquitination at Lys28
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJB11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJB11 Gene

Domains & Families for DNAJB11 Gene

Gene Families for DNAJB11 Gene

Protein Domains for DNAJB11 Gene

Suggested Antigen Peptide Sequences for DNAJB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJB11: view

No data available for UniProtKB/Swiss-Prot for DNAJB11 Gene

Function for DNAJB11 Gene

Molecular function for DNAJB11 Gene

UniProtKB/Swiss-Prot Function:
Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.
UniProtKB/Swiss-Prot Induction:
By endoplasmic reticulum stress-inducing agents such as thapsigargin and tunicamycin.

Gene Ontology (GO) - Molecular Function for DNAJB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18923428
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with DNAJB11: view
genes like me logo Genes that share phenotypes with DNAJB11: view

Animal Model Products

CRISPR Products

miRNA for DNAJB11 Gene

miRTarBase miRNAs that target DNAJB11

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJB11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB11 Gene

Localization for DNAJB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB11 Gene

Endoplasmic reticulum lumen. Note=Associated with the ER membrane in a C-terminally epitope-tagged construct.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB11 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
plasma membrane 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 16130169
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DNAJB11: view

Pathways & Interactions for DNAJB11 Gene

genes like me logo Genes that share pathways with DNAJB11: view

Pathways by source for DNAJB11 Gene

Gene Ontology (GO) - Biological Process for DNAJB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0032781 positive regulation of ATPase activity IDA 20335166
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with DNAJB11: view

No data available for SIGNOR curated interactions for DNAJB11 Gene

Drugs & Compounds for DNAJB11 Gene

No Compound Related Data Available

Transcripts for DNAJB11 Gene

mRNA/cDNA for DNAJB11 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(291) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAJB11 Gene

DnaJ (Hsp40) homolog, subfamily B, member 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJB11

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB11 Gene

No ASD Table

Relevant External Links for DNAJB11 Gene

GeneLoc Exon Structure for
DNAJB11
ECgene alternative splicing isoforms for
DNAJB11

Expression for DNAJB11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJB11 Gene

Protein differential expression in normal tissues from HIPED for DNAJB11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJB11 Gene



Protein tissue co-expression partners for DNAJB11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJB11 Gene:

DNAJB11

SOURCE GeneReport for Unigene cluster for DNAJB11 Gene:

Hs.317192

mRNA Expression by UniProt/SwissProt for DNAJB11 Gene:

Q9UBS4-DJB11_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for DNAJB11 Gene

  • Liver(4.5)
  • Lung(4.4)
  • Muscle(4.3)
  • Nervous system(2.4)
  • Heart(2.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with DNAJB11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB11 Gene

Orthologs for DNAJB11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB11 34 33
  • 99.81 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB11 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJB11 34 33
  • 93.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB11 34 33
  • 91.9 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJB11 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb11 16 34 33
  • 90.78 (n)
rat
(Rattus norvegicus)
Mammalia Dnajb11 33
  • 90.32 (n)
chicken
(Gallus gallus)
Aves DNAJB11 34 33
  • 78.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJB11 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb11 33
  • 76.34 (n)
MGC75796 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5180 33
zebrafish
(Danio rerio)
Actinopterygii dnajb11 34 33 33
  • 71.67 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008327 33
  • 61.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4164 34 35 33
  • 59.98 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dnj-20 34 33
  • 59.07 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDJ1 34
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATERDJ3B 33
  • 54.41 (n)
rice
(Oryza sativa)
Liliopsida Os05g0156500 33
  • 54.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9772 34
  • 52 (a)
OneToOne
Cin.4254 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4254 33
Species where no ortholog for DNAJB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJB11 Gene

ENSEMBL:
Gene Tree for DNAJB11 (if available)
TreeFam:
Gene Tree for DNAJB11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJB11: view image

Paralogs for DNAJB11 Gene

Paralogs for DNAJB11 Gene

(7) SIMAP similar genes for DNAJB11 Gene using alignment to 3 proteins:

  • DJB11_HUMAN
  • F5GXK8_HUMAN
  • H7C2Y5_HUMAN
genes like me logo Genes that share paralogs with DNAJB11: view

Variants for DNAJB11 Gene

Sequence variations from dbSNP and Humsavar for DNAJB11 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000067910 -- 186,571,568(+) G/C intron_variant
rs1000314712 -- 186,582,562(+) C/G intron_variant
rs1000448123 -- 186,575,293(+) G/A intron_variant
rs1001056698 -- 186,576,439(+) T/C intron_variant
rs1001332263 -- 186,581,590(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJB11 Gene

Variant ID Type Subtype PubMed ID
esv3569153 CNV loss 25503493
esv3569155 CNV loss 25503493

Variation tolerance for DNAJB11 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.43; 85.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJB11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB11 Gene

Disorders for DNAJB11 Gene

Additional Disease Information for DNAJB11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DNAJB11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB11 Gene

Publications for DNAJB11 Gene

  1. HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells. (PMID: 10827079) Yu M … Haslam DB (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Localization and function in endoplasmic reticulum stress tolerance of ERdj3, a new member of Hsp40 family protein. (PMID: 15544163) Nakanishi K … Sato N (Cell stress & chaperones 2004) 3 4 22 58
  3. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K … Hata M (Cell stress & chaperones 2000) 2 3 4 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Contribution of the HEDJ/ERdj3 cysteine-rich domain to substrate interactions. (PMID: 17976514) Marcus NY … Haslam DB (Archives of biochemistry and biophysics 2007) 3 4 58

Products for DNAJB11 Gene

Sources for DNAJB11 Gene

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