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Aliases for CAB39 Gene

Aliases for CAB39 Gene

  • Calcium Binding Protein 39 2 3 5
  • MO25alpha 3 4
  • MO25 3 4
  • Calcium-Binding Protein 39 3
  • Protein Mo25 4
  • CGI-66 3

External Ids for CAB39 Gene

Previous GeneCards Identifiers for CAB39 Gene

  • GC00U916965
  • GC02P231403
  • GC02P231285
  • GC02P231577
  • GC02P223417

Summaries for CAB39 Gene

GeneCards Summary for CAB39 Gene

CAB39 (Calcium Binding Protein 39) is a Protein Coding gene. Among its related pathways are LKB1 signaling events and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include binding and kinase binding. An important paralog of this gene is CAB39L.

UniProtKB/Swiss-Prot for CAB39 Gene

  • Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.

Gene Wiki entry for CAB39 Gene

Additional gene information for CAB39 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAB39 Gene

Genomics for CAB39 Gene

GeneHancer (GH) Regulatory Elements for CAB39 Gene

Promoters and enhancers for CAB39 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J230711 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 655.8 +1.0 971 5.3 HDGF FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 IRF4 CAB39 RNU6-268P TRIP12 NCL PSMD1 DNER BANF1P3
GH02J230656 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.6 -52.0 -51996 8.4 HDGF PKNOX1 SMAD1 ARNT YBX1 IRF4 POLR2B ZNF766 ZNF207 ZNF143 ENSG00000224376 CAB39 LOC101928816 RNU6-451P ZBTB8OSP2 LINC00471 SP110 SP140 GPR55 ARMC9
GH02J230792 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +82.0 81990 4.6 PKNOX1 JUN MAX EBF1 GATA3 ZNF316 POLR2A ATF7 FOSL2 FOS CAB39 SP100 RNU6-268P SPATA3 SPATA3-AS1 SP140L GC02P230779 ENSG00000270891
GH02J230666 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -44.6 -44584 3.6 HDGF ATF1 IRF4 ZNF766 ATF7 RUNX3 JUNB NCOA1 ZNF592 SMARCA4 CAB39 RNU6-451P RNU6-268P GPR55 SP100 SP110 SP140 LINC01907 GC02P230588
GH02J230773 Enhancer 1.2 Ensembl ENCODE dbSUPER 16.1 +63.9 63905 6.8 SMAD1 TCF12 ZFP91 ATF7 FOS IKZF2 RUNX3 CREM CBFB JUNB CAB39 RNU6-268P LINC01907 GC02P230779
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAB39 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAB39 gene promoter:
  • FAC1
  • TBP
  • S8
  • Pax-2
  • Pax-2a

Genomic Locations for CAB39 Gene

Genomic Locations for CAB39 Gene
108,234 bases
Plus strand
108,234 bases
Plus strand

Genomic View for CAB39 Gene

Genes around CAB39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAB39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAB39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAB39 Gene

Proteins for CAB39 Gene

  • Protein details for CAB39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium-binding protein 39
    Protein Accession:
    Secondary Accessions:
    • A8K8L7

    Protein attributes for CAB39 Gene

    341 amino acids
    Molecular mass:
    39869 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

    Three dimensional structures from OCA and Proteopedia for CAB39 Gene

neXtProt entry for CAB39 Gene

Post-translational modifications for CAB39 Gene

  • Ubiquitination at posLast=301301
  • Modification sites at PhosphoSitePlus

Other Protein References for CAB39 Gene

No data available for DME Specific Peptides for CAB39 Gene

Domains & Families for CAB39 Gene

Gene Families for CAB39 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAB39 Gene


Suggested Antigen Peptide Sequences for CAB39 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Mo25 family.
  • Belongs to the Mo25 family.
genes like me logo Genes that share domains with CAB39: view

Function for CAB39 Gene

Molecular function for CAB39 Gene

UniProtKB/Swiss-Prot Function:
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.

Gene Ontology (GO) - Molecular Function for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 contributes_to protein serine/threonine kinase activity IDA 24393035
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 14676191
GO:0019900 kinase binding IPI 19892943
GO:0030295 protein kinase activator activity IDA 19892943
genes like me logo Genes that share ontologies with CAB39: view
genes like me logo Genes that share phenotypes with CAB39: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAB39 Gene

Localization for CAB39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAB39 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAB39 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0034774 secretory granule lumen TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with CAB39: view

Pathways & Interactions for CAB39 Gene

genes like me logo Genes that share pathways with CAB39: view

Pathways by source for CAB39 Gene

1 R&D Systems pathway for CAB39 Gene
1 Qiagen pathway for CAB39 Gene
1 Cell Signaling Technology pathway for CAB39 Gene

Gene Ontology (GO) - Biological Process for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007050 cell cycle arrest TAS --
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA 24393035
GO:0018105 peptidyl-serine phosphorylation IDA 24393035
GO:0023014 signal transduction by protein phosphorylation IDA 24393035
genes like me logo Genes that share ontologies with CAB39: view

No data available for SIGNOR curated interactions for CAB39 Gene

Drugs & Compounds for CAB39 Gene

No Compound Related Data Available

Transcripts for CAB39 Gene

Unigene Clusters for CAB39 Gene

Calcium binding protein 39:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAB39 Gene

No ASD Table

Relevant External Links for CAB39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAB39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAB39 Gene

Protein differential expression in normal tissues from HIPED for CAB39 Gene

This gene is overexpressed in Urine (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAB39 Gene

Protein tissue co-expression partners for CAB39 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAB39 Gene:


SOURCE GeneReport for Unigene cluster for CAB39 Gene:


Evidence on tissue expression from TISSUES for CAB39 Gene

  • Nervous system(4.8)
  • Intestine(4.4)
  • Liver(4.4)
  • Kidney(2.5)
  • Muscle(2.3)
  • Lung(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CAB39: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAB39 Gene

Orthologs for CAB39 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAB39 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia CAB39 34
  • 100 (a)
(Monodelphis domestica)
Mammalia CAB39 34
  • 100 (a)
(Pan troglodytes)
Mammalia CAB39 34 33
  • 99.9 (n)
(Canis familiaris)
Mammalia CAB39 34 33
  • 94.82 (n)
(Bos Taurus)
Mammalia CAB39 34 33
  • 94.04 (n)
(Mus musculus)
Mammalia Cab39 16 34 33
  • 92.47 (n)
(Gallus gallus)
Aves CAB39 34 33
  • 88.17 (n)
(Anolis carolinensis)
Reptilia CAB39 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486569 33
  • 80.45 (n)
(Danio rerio)
Actinopterygii cab39 34 33
  • 79.57 (n)
Dr.9072 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000812 33
  • 64.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mo25 34 33
  • 63.84 (n)
(Caenorhabditis elegans)
Secernentea mop-25.1 34 33
  • 61.68 (n)
mop-25.2 34
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYM1 36 34
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17270 33
  • 52.38 (n)
(Glycine max)
eudicotyledons Gma.4699 33
(Oryza sativa)
Liliopsida Os07g0585100 33
  • 54.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3108 34
  • 67 (a)
Species where no ortholog for CAB39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAB39 Gene

Gene Tree for CAB39 (if available)
Gene Tree for CAB39 (if available)
Evolutionary constrained regions (ECRs) for CAB39: view image

Paralogs for CAB39 Gene

Paralogs for CAB39 Gene

(1) SIMAP similar genes for CAB39 Gene using alignment to 1 proteins:

  • CAB39_HUMAN Pseudogenes for CAB39 Gene

genes like me logo Genes that share paralogs with CAB39: view

Variants for CAB39 Gene

Sequence variations from dbSNP and Humsavar for CAB39 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000015704 -- 230,813,230(+) G/C 3_prime_UTR_variant, intron_variant
rs1000042018 -- 230,803,763(+) G/A intron_variant
rs1000054590 -- 230,722,620(+) A/T intron_variant
rs1000100281 -- 230,756,279(+) A/G/T intron_variant
rs1000108818 -- 230,797,617(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAB39 Gene

Variant ID Type Subtype PubMed ID
esv2671712 CNV deletion 23128226
esv2674961 CNV deletion 23128226
esv2760618 CNV loss 21179565
esv3594611 CNV loss 21293372
esv3594612 CNV loss 21293372
esv3594613 CNV loss 21293372
nsv584675 CNV loss 21841781
nsv834565 CNV gain 17160897
nsv953197 CNV duplication 24416366
nsv961569 CNV duplication 23825009

Variation tolerance for CAB39 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAB39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAB39 Gene

Disorders for CAB39 Gene

Additional Disease Information for CAB39

No disorders were found for CAB39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAB39 Gene

Publications for CAB39 Gene

  1. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. (PMID: 19892943) Zeqiraj E … van Aalten DM (Science (New York, N.Y.) 2009) 3 4 58
  2. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. (PMID: 19513107) Zeqiraj E … van Aalten DM (PLoS biology 2009) 3 22 58
  3. Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. (PMID: 14730349) Milburn CC … van Aalten DM (Nature structural & molecular biology 2004) 3 4 58
  4. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PMID: 14976552) Lizcano JM … Alessi DR (The EMBO journal 2004) 3 22 58
  5. LKB1 tumor suppressor protein: PARtaker in cell polarity. (PMID: 15183188) Baas AF … Clevers H (Trends in cell biology 2004) 3 22 58

Products for CAB39 Gene

Sources for CAB39 Gene

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