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Aliases for SELENOT Gene

Aliases for SELENOT Gene

  • Selenoprotein T 2 3 5
  • SELT 3 4
  • Thioredoxin Reductase-Like Selenoprotein T 3
  • Thioredoxin Reductase-Like Enzyme 3
  • EC 1.8.1.9 4
  • SelT 4

External Ids for SELENOT Gene

Summaries for SELENOT Gene

Entrez Gene Summary for SELENOT Gene

  • This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017]

GeneCards Summary for SELENOT Gene

SELENOT (Selenoprotein T) is a Protein Coding gene. Among its related pathways are Folate Metabolism and Selenium Metabolism and Selenoproteins.

UniProtKB/Swiss-Prot for SELENOT Gene

  • Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).

Gene Wiki entry for SELENOT Gene

Additional gene information for SELENOT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOT Gene

Genomics for SELENOT Gene

GeneHancer (GH) Regulatory Elements for SELENOT Gene

Promoters and enhancers for SELENOT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J150598 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 656 -0.3 -290 8.8 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF213 E2F8 MEF2D ZNF610 ZNF585B SELENOT SERP1 EIF2A RPL32P9 LOC730021 COMMD2 TSC22D2 ERICH6 ERICH6-AS1
GH03J150543 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.1 -56.6 -56604 4.7 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 EIF2A SERP1 COMMD2 SELENOT GC03M150475
GH03J150634 Enhancer 0.8 Ensembl ENCODE 11.7 +33.1 33108 2.1 EBF1 MEF2B ELF1 ATF2 NFATC1 ZSCAN29 RUNX3 SPI1 SELENOT SERP1 ERICH6-AS1 ERICH6 EIF2A GC03P150627
GH03J150662 Enhancer 0.5 Ensembl 11.3 +59.8 59826 0.2 ZNF316 L3MBTL2 NRF1 MAFG NFE2 EMSY ERICH6-AS1 ERICH6 SELENOT SERP1 ENSG00000243273 MINDY4B GC03P150627
GH03J150723 Enhancer 0.5 dbSUPER 10.7 +121.1 121103 1.3 ZNF512B RFX1 ZNF366 ZNF512 IKZF1 NFE2 ERICH6-AS1 SIAH2-AS1 SIAH2 ENSG00000243273 MINDY4B SELENOT SERP1 SNRPCP3 LOC101928105
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELENOT on UCSC Golden Path with GeneCards custom track

Genomic Locations for SELENOT Gene

Genomic Locations for SELENOT Gene
chr3:150,602,875-150,630,447
(GRCh38/hg38)
Size:
27,573 bases
Orientation:
Plus strand
chr3:150,320,662-150,348,234
(GRCh37/hg19)
Size:
27,573 bases
Orientation:
Plus strand

Genomic View for SELENOT Gene

Genes around SELENOT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOT Gene

Proteins for SELENOT Gene

  • Protein details for SELENOT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62341-SELT_HUMAN
    Recommended name:
    Thioredoxin reductase-like selenoprotein T
    Protein Accession:
    P62341
    Secondary Accessions:
    • O95904
    • Q8IY80
    • Q9CZ45
    • Q9NZJ3

    Protein attributes for SELENOT Gene

    Size:
    195 amino acids
    Molecular mass:
    22324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD20063.1; Type=Erroneous termination; Positions=49; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAF13696.1; Type=Frameshift; Positions=27; Evidence={ECO:0000305}; Sequence=AAQ88462.1; Type=Erroneous termination; Positions=49; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAQ88463.1; Type=Erroneous termination; Positions=49; Note=Translated as Sec.; Evidence={ECO:0000305};

neXtProt entry for SELENOT Gene

Post-translational modifications for SELENOT Gene

  • May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOT Gene

No data available for DME Specific Peptides for SELENOT Gene

Domains & Families for SELENOT Gene

Gene Families for SELENOT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SELENOT Gene

Suggested Antigen Peptide Sequences for SELENOT Gene

Graphical View of Domain Structure for InterPro Entry

P62341

UniProtKB/Swiss-Prot:

SELT_HUMAN :
  • Belongs to the SelWTH family. Selenoprotein T subfamily.
Family:
  • Belongs to the SelWTH family. Selenoprotein T subfamily.
genes like me logo Genes that share domains with SELENOT: view

Function for SELENOT Gene

Molecular function for SELENOT Gene

UniProtKB/Swiss-Prot Function:
Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
UniProtKB/Swiss-Prot Induction:
Induced by Parkinson disease-inducing neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Enzyme Numbers (IUBMB) for SELENOT Gene

Gene Ontology (GO) - Molecular Function for SELENOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004791 thioredoxin-disulfide reductase activity ISS --
GO:0008430 selenium binding NAS 10567350
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with SELENOT: view
genes like me logo Genes that share phenotypes with SELENOT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SELENOT

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SELENOT Gene

Localization for SELENOT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOT Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOT gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SELENOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SELENOT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SELENOT Gene

Pathways & Interactions for SELENOT Gene

genes like me logo Genes that share pathways with SELENOT: view

Pathways by source for SELENOT Gene

Interacting Proteins for SELENOT Gene

Gene Ontology (GO) - Biological Process for SELENOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation NAS 10567350
GO:0007204 positive regulation of cytosolic calcium ion concentration ISS --
GO:0009749 response to glucose IEA,ISS --
GO:0031016 pancreas development ISS,IEA --
GO:0035773 insulin secretion involved in cellular response to glucose stimulus IEA,ISS --
genes like me logo Genes that share ontologies with SELENOT: view

No data available for SIGNOR curated interactions for SELENOT Gene

Drugs & Compounds for SELENOT Gene

(1) Drugs for SELENOT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SELENOT: view

Transcripts for SELENOT Gene

mRNA/cDNA for SELENOT Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOT Gene

No ASD Table

Relevant External Links for SELENOT Gene

GeneLoc Exon Structure for
SELENOT
ECgene alternative splicing isoforms for
SELENOT

Expression for SELENOT Gene

mRNA Expression by UniProt/SwissProt for SELENOT Gene:

P62341-SELT_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in the endocrine pancreas.

Evidence on tissue expression from TISSUES for SELENOT Gene

  • Nervous system(5)
  • Skin(4.8)
  • Pancreas(4.4)
  • Bone marrow(4.3)
  • Liver(4.2)
  • Kidney(2.5)
  • Lung(2.2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOT Gene

Orthologs for SELENOT Gene

This gene was present in the common ancestor of animals.

Orthologs for SELENOT Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELT 34 33
  • 96.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SELT 34 33
  • 95.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Selt 34 33
  • 95.21 (n)
OneToOne
Selenot 16
rat
(Rattus norvegicus)
Mammalia Selt 33
  • 95.21 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELT 34 33
  • 86.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selt 33
  • 82.97 (n)
MGC75917 33
zebrafish
(Danio rerio)
Actinopterygii selt1a 34 33
  • 75.51 (n)
OneToMany
selt1b 34
  • 75 (a)
OneToMany
selt2 34
  • 46 (a)
OneToMany
sept1a 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8427 33
fruit fly
(Drosophila melanogaster)
Insecta CG3887 34 33
  • 53.67 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009202 33
  • 52.16 (n)
worm
(Caenorhabditis elegans)
Secernentea C35C5.3 34
  • 24 (a)
OneToMany
F28H7.4 34
  • 23 (a)
OneToMany
Species where no ortholog for SELENOT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELENOT Gene

ENSEMBL:
Gene Tree for SELENOT (if available)
TreeFam:
Gene Tree for SELENOT (if available)

Paralogs for SELENOT Gene

Pseudogenes.org Pseudogenes for SELENOT Gene

genes like me logo Genes that share paralogs with SELENOT: view

No data available for Paralogs for SELENOT Gene

Variants for SELENOT Gene

Sequence variations from dbSNP and Humsavar for SELENOT Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000002145 -- 150,614,875(+) A/T intron_variant
rs1000030094 -- 150,601,650(+) A/C upstream_transcript_variant
rs1000158171 -- 150,624,324(+) C/G intron_variant
rs1000266382 -- 150,607,741(+) C/T intron_variant
rs1000353002 -- 150,615,011(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SELENOT Gene

Variant ID Type Subtype PubMed ID
esv3569056 CNV loss 25503493
nsv963367 CNV duplication 23825009

Variation tolerance for SELENOT Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SELENOT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOT Gene

Disorders for SELENOT Gene

UniProtKB/Swiss-Prot

SELT_HUMAN
  • Note=mRNA levels are increased more than 200-folds in the caudate putamen from Parkinson disease (PD) patients compared to control subjects. In conditional brain knockout mice, treatment with PD-inducing neurotoxins provoke rapid and severe parkinsonian-like motor defects. {ECO:0000269 PubMed:26866473}.

No disorders were found for SELENOT Gene.

No data available for MalaCards and Genatlas for SELENOT Gene

Publications for SELENOT Gene

  1. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. (PMID: 10567350) Kryukov GV … Gladyshev VN (The Journal of biological chemistry 1999) 2 3 4 58
  2. Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease. (PMID: 26866473) Boukhzar L … Anouar Y (Antioxidants & redox signaling 2016) 3 4 58
  3. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev VN … Zhang Y (The Journal of biological chemistry 2016) 3 4 58
  4. The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human β-cells and its targeted inactivation impairs glucose tolerance. (PMID: 23913443) Prevost G … Anouar Y (Endocrinology 2013) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SELENOT Gene

Sources for SELENOT Gene

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