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Aliases for MRPS33 Gene

Aliases for MRPS33 Gene

  • Mitochondrial Ribosomal Protein S33 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein MS33 3 4
  • MRP-S33 3 4
  • S33mt 3 4
  • 28S Ribosomal Protein S33, Mitochondrial 3
  • CGI-139 3
  • PTD003 3

External Ids for MRPS33 Gene

Previous GeneCards Identifiers for MRPS33 Gene

  • GC07M138976
  • GC07M140036
  • GC07M140113
  • GC07M140159
  • GC07M140352
  • GC07M140705
  • GC07M135002

Summaries for MRPS33 Gene

Entrez Gene Summary for MRPS33 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS33 Gene

MRPS33 (Mitochondrial Ribosomal Protein S33) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS33 Gene

Additional gene information for MRPS33 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS33 Gene

Genomics for MRPS33 Gene

GeneHancer (GH) Regulatory Elements for MRPS33 Gene

Promoters and enhancers for MRPS33 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J141013 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.9 896 2.6 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 NBN MRPS33 TAS2R5 TAS2R6P SLC37A3 TMEM178B BRAF NDUFB2-AS1 NDUFB2 CCT4P1 LOC105375536
GH07J140923 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 +90.6 90605 2.9 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 IRF4 BRAF LOC105375536 NDUFB2 TAS2R5 MRPS33 TAS2R6P NDUFB2-AS1 ADCK2 RNU6-85P
GH07J141001 Enhancer 0.8 ENCODE 12.6 +12.1 12110 2.4 PKNOX1 MLX ZNF133 RAD21 RARA THAP11 MIXL1 RXRA REST NR2F2 TMEM178B MRPS33 NDUFB2-AS1 NDUFB2 CCT4P1 LOC105375536
GH07J140517 Enhancer 1.4 Ensembl ENCODE dbSUPER 6.2 +496.4 496412 2.6 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF280A ARID2 SLC37A3 BRAF NDUFB2-AS1 NDUFB2 DENND2A MRPS33 MKRN1 ENSG00000201354
GH07J140992 Enhancer 0.7 ENCODE 11.1 +22.6 22592 0.2 ELF3 IRF2 FOXA2 NFXL1 ZNF644 ZNF48 RARA CTBP1 GATA3 NR2F6 MRPS33 BRAF NDUFB2-AS1 NDUFB2 CCT4P1 LOC105375536
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPS33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS33 gene promoter:
  • NCX
  • Egr-4
  • Pax-6
  • En-1
  • AREB6

Genomic Locations for MRPS33 Gene

Genomic Locations for MRPS33 Gene
12,619 bases
Minus strand
9,175 bases
Minus strand

Genomic View for MRPS33 Gene

Genes around MRPS33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS33 Gene

Proteins for MRPS33 Gene

  • Protein details for MRPS33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S33, mitochondrial
    Protein Accession:

    Protein attributes for MRPS33 Gene

    106 amino acids
    Molecular mass:
    12629 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS33 Gene

neXtProt entry for MRPS33 Gene

Post-translational modifications for MRPS33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS33 Gene

No data available for DME Specific Peptides for MRPS33 Gene

Domains & Families for MRPS33 Gene

Gene Families for MRPS33 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS33 Gene


Suggested Antigen Peptide Sequences for MRPS33 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrion-specific ribosomal protein mS33 family.
  • Belongs to the mitochondrion-specific ribosomal protein mS33 family.
genes like me logo Genes that share domains with MRPS33: view

Function for MRPS33 Gene

Gene Ontology (GO) - Molecular Function for MRPS33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS33: view
genes like me logo Genes that share phenotypes with MRPS33: view

Animal Model Products

CRISPR Products

miRNA for MRPS33 Gene

miRTarBase miRNAs that target MRPS33

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS33

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS33 Gene

Localization for MRPS33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS33 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS33 gene
Compartment Confidence
mitochondrion 5
nucleus 3

Gene Ontology (GO) - Cellular Components for MRPS33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS33: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPS33 Gene

Pathways & Interactions for MRPS33 Gene

genes like me logo Genes that share pathways with MRPS33: view

Gene Ontology (GO) - Biological Process for MRPS33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS33: view

No data available for SIGNOR curated interactions for MRPS33 Gene

Drugs & Compounds for MRPS33 Gene

No Compound Related Data Available

Transcripts for MRPS33 Gene

mRNA/cDNA for MRPS33 Gene

Unigene Clusters for MRPS33 Gene

Mitochondrial ribosomal protein S33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRPS33

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS33 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -

Relevant External Links for MRPS33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS33 Gene

This gene is overexpressed in Breast (27.4) and Lung (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPS33 Gene

Protein tissue co-expression partners for MRPS33 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPS33 Gene:


SOURCE GeneReport for Unigene cluster for MRPS33 Gene:


Evidence on tissue expression from TISSUES for MRPS33 Gene

  • Lung(4.4)
genes like me logo Genes that share expression patterns with MRPS33: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS33 Gene

Orthologs for MRPS33 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS33 34 33
  • 99.06 (n)
(Canis familiaris)
Mammalia MRPS33 33
  • 84.59 (n)
-- 34
  • 84 (a)
-- 34
  • 75 (a)
(Bos Taurus)
Mammalia MRPS33 34 33
  • 84.28 (n)
(Mus musculus)
Mammalia Mrps33 16 34 33
  • 82.7 (n)
(Rattus norvegicus)
Mammalia Mrps33 33
  • 82.37 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
-- 34
  • 78 (a)
-- 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS33 34
  • 71 (a)
(Gallus gallus)
Aves MRPS33 34 33
  • 73.9 (n)
(Anolis carolinensis)
Reptilia MRPS33 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps33 33
  • 65.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29741 33
(Danio rerio)
Actinopterygii mrps33 34 33
  • 65.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002777 33
  • 56.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS33 34 33
  • 53.8 (n)
(Caenorhabditis elegans)
Secernentea mrps-33 34
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for MRPS33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS33 Gene

Gene Tree for MRPS33 (if available)
Gene Tree for MRPS33 (if available)
Evolutionary constrained regions (ECRs) for MRPS33: view image

Paralogs for MRPS33 Gene Pseudogenes for MRPS33 Gene

genes like me logo Genes that share paralogs with MRPS33: view

No data available for Paralogs for MRPS33 Gene

Variants for MRPS33 Gene

Sequence variations from dbSNP and Humsavar for MRPS33 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000112170 -- 141,013,613(-) C/G intron_variant
rs1001017135 -- 141,007,903(-) C/G intron_variant
rs1001030070 -- 141,008,253(-) TTTTT/TTTT intron_variant
rs1001065416 -- 141,015,051(-) A/ upstream_transcript_variant
rs1001225004 -- 141,014,375(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS33 Gene

Variant ID Type Subtype PubMed ID
dgv6645n100 CNV gain 25217958
nsv473706 CNV novel sequence insertion 20440878
nsv476456 CNV novel sequence insertion 20440878

Variation tolerance for MRPS33 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 51.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS33 Gene

Disorders for MRPS33 Gene

Additional Disease Information for MRPS33

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS33 Gene

Publications for MRPS33 Gene

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4 58
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for MRPS33 Gene

Sources for MRPS33 Gene

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