Aliases for OTUD6B Gene
External Ids for OTUD6B Gene
Previous GeneCards Identifiers for OTUD6B Gene
This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013]
GeneCards Summary for OTUD6B Gene
OTUD6B (OTU Domain Containing 6B) is a Protein Coding gene. Diseases associated with OTUD6B include Intellectual Developmental Disorder With Dysmorphic Facies, Seizures, And Distal Limb Anomalies and Alacrima, Achalasia, And Mental Retardation Syndrome. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is OTUD6A.
UniProtKB/Swiss-Prot for OTUD6B Gene
Isoform 1: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629).
Isoform 2: Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability.