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Aliases for LUC7L2 Gene

Aliases for LUC7L2 Gene

  • LUC7 Like 2, Pre-MRNA Splicing Factor 2 3 5
  • Putative RNA-Binding Protein Luc7-Like 2 3
  • LUC7-Like 2 (S. Cerevisiae) 2
  • CGI-74 Protein 2
  • LUC7-Like 2 3
  • CGI-59 3
  • CGI-74 3
  • LUC7B2 3

External Ids for LUC7L2 Gene

Previous GeneCards Identifiers for LUC7L2 Gene

  • GC07P138445
  • GC07P138459
  • GC07P138501
  • GC07P138695
  • GC07P139026
  • GC07P133354
  • GC07P139341

Summaries for LUC7L2 Gene

Entrez Gene Summary for LUC7L2 Gene

  • This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for LUC7L2 Gene

LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is C7orf55-LUC7L2.

UniProtKB/Swiss-Prot for LUC7L2 Gene

  • May bind to RNA via its Arg/Ser-rich domain.

Gene Wiki entry for LUC7L2 Gene

Additional gene information for LUC7L2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUC7L2 Gene

Genomics for LUC7L2 Gene

GeneHancer (GH) Regulatory Elements for LUC7L2 Gene

Promoters and enhancers for LUC7L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J139339 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 728.5 +0.9 925 3.9 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D LUC7L2 TRR-CCT4-1 FMC1 GC07P139359 GC07P139358 C7orf55-LUC7L2 UBN2 ENSG00000273391 KLRG2 TTC26
GH07J139357 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 675.9 +19.8 19776 4.3 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 LUC7L2 ENSG00000273391 UBN2 IMPDH1P3 RNU6-206P TBXAS1 GC07P139363 C7orf55-LUC7L2
GH07J139367 Promoter/Enhancer 1.1 EPDnew dbSUPER 662 +27.4 27373 0.1 ZNF189 MAFG EBF1 MEF2B BATF ATF2 ZNF316 NFE2 EMSY ZBTB17 LUC7L2 FMC1 GC07P139363 C7orf55-LUC7L2 LOC100129148
GH07J139363 Promoter/Enhancer 1 EPDnew dbSUPER 650.3 +22.3 22264 0.1 GLIS2 ZBTB48 IKZF1 ZNF580 MZF1 PRDM10 GC07P139363 LUC7L2 ENSG00000273391 C7orf55-LUC7L2
GH07J139374 Promoter/Enhancer 0.7 EPDnew dbSUPER 661.6 +34.5 34471 0.1 LUC7L2 FMC1 GC07P139363 C7orf55-LUC7L2 LOC100129148
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LUC7L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LUC7L2 gene promoter:
  • E2F-3a
  • FOXO4
  • E2F
  • E2F-1
  • E2F-2
  • E2F-4

Genomic Locations for LUC7L2 Gene

Genomic Locations for LUC7L2 Gene
83,099 bases
Plus strand
82,095 bases
Plus strand

Genomic View for LUC7L2 Gene

Genes around LUC7L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUC7L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUC7L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUC7L2 Gene

Proteins for LUC7L2 Gene

  • Protein details for LUC7L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative RNA-binding protein Luc7-like 2
    Protein Accession:
    Secondary Accessions:
    • B7Z500
    • Q8IUP9
    • Q9NVL3
    • Q9NVN7
    • Q9UQN1

    Protein attributes for LUC7L2 Gene

    392 amino acids
    Molecular mass:
    46514 Da
    Quaternary structure:
    • Interacts with SCNM1.
    • Sequence=AAD34069.1; Type=Frameshift; Positions=388; Evidence={ECO:0000305};

    Alternative splice isoforms for LUC7L2 Gene


neXtProt entry for LUC7L2 Gene

Post-translational modifications for LUC7L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LUC7L2 Gene

No data available for DME Specific Peptides for LUC7L2 Gene

Domains & Families for LUC7L2 Gene

Gene Families for LUC7L2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LUC7L2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Luc7 family.
  • Belongs to the Luc7 family.
genes like me logo Genes that share domains with LUC7L2: view

Function for LUC7L2 Gene

Molecular function for LUC7L2 Gene

UniProtKB/Swiss-Prot Function:
May bind to RNA via its Arg/Ser-rich domain.

Phenotypes From GWAS Catalog for LUC7L2 Gene

Gene Ontology (GO) - Molecular Function for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 15324660
GO:0019899 enzyme binding IPI 19574390
genes like me logo Genes that share ontologies with LUC7L2: view
genes like me logo Genes that share phenotypes with LUC7L2: view

Animal Model Products

CRISPR Products

miRNA for LUC7L2 Gene

miRTarBase miRNAs that target LUC7L2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LUC7L2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LUC7L2 Gene

Localization for LUC7L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUC7L2 Gene

Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and SNRNP70 in nuclear speckles. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LUC7L2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA --
GO:0005685 U1 snRNP IBA --
GO:0016607 nuclear speck IEA --
GO:0071004 U2-type prespliceosome IBA --
genes like me logo Genes that share ontologies with LUC7L2: view

Pathways & Interactions for LUC7L2 Gene

SuperPathways for LUC7L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IBA --
genes like me logo Genes that share ontologies with LUC7L2: view

No data available for Pathways by source and SIGNOR curated interactions for LUC7L2 Gene

Drugs & Compounds for LUC7L2 Gene

No Compound Related Data Available

Transcripts for LUC7L2 Gene

mRNA/cDNA for LUC7L2 Gene

Unigene Clusters for LUC7L2 Gene

LUC7-like 2 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LUC7L2

Alternative Splicing Database (ASD) splice patterns (SP) for LUC7L2 Gene

No ASD Table

Relevant External Links for LUC7L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LUC7L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LUC7L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LUC7L2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LUC7L2 Gene

Protein tissue co-expression partners for LUC7L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LUC7L2 Gene:


SOURCE GeneReport for Unigene cluster for LUC7L2 Gene:


Evidence on tissue expression from TISSUES for LUC7L2 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(4.3)
  • Kidney(2.5)
  • Lung(2.4)
  • Spleen(2.1)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with LUC7L2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LUC7L2 Gene

Orthologs for LUC7L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LUC7L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LUC7L2 34 33
  • 99.91 (n)
(Canis familiaris)
Mammalia LUC7L2 34 33
  • 95.41 (n)
(Bos Taurus)
Mammalia LUC7L2 33
  • 95.41 (n)
-- 34
  • 81 (a)
(Rattus norvegicus)
Mammalia Luc7l2 33
  • 93.79 (n)
(Mus musculus)
Mammalia Luc7l2 16 34 33
  • 93.71 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
(Gallus gallus)
Aves LUC7L2 34 33
  • 84.51 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia luc7l2 33
  • 80.91 (n)
Str.1795 33
African clawed frog
(Xenopus laevis)
Amphibia cg7564-prov 33
(Danio rerio)
Actinopterygii C1H7orf55 34
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7564 34
  • 47 (a)
(Caenorhabditis elegans)
Secernentea B0495.8 34
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
Species where no ortholog for LUC7L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LUC7L2 Gene

Gene Tree for LUC7L2 (if available)
Gene Tree for LUC7L2 (if available)
Evolutionary constrained regions (ECRs) for LUC7L2: view image

Paralogs for LUC7L2 Gene

Paralogs for LUC7L2 Gene

(3) SIMAP similar genes for LUC7L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LUC7L2: view

Variants for LUC7L2 Gene

Sequence variations from dbSNP and Humsavar for LUC7L2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000078372 -- 139,356,027(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000087403 -- 139,339,108(+) C/T upstream_transcript_variant
rs1000154260 -- 139,366,595(+) C/T intron_variant
rs1000162485 -- 139,359,653(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000163825 -- 139,379,124(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LUC7L2 Gene

Variant ID Type Subtype PubMed ID
esv2292861 CNV deletion 18987734
esv2371727 CNV deletion 18987734
esv2735212 CNV deletion 23290073
esv2735231 CNV deletion 23290073
esv3572165 CNV loss 25503493
esv3572166 CNV loss 25503493
nsv1110976 OTHER inversion 24896259
nsv1117762 CNV deletion 24896259
nsv1137296 CNV deletion 24896259
nsv478581 CNV novel sequence insertion 20440878

Variation tolerance for LUC7L2 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LUC7L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUC7L2 Gene

Disorders for LUC7L2 Gene

Additional Disease Information for LUC7L2

No disorders were found for LUC7L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LUC7L2 Gene

Publications for LUC7L2 Gene

  1. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PMID: 19574390) Webby CJ … Böttger A (Science (New York, N.Y.) 2009) 3 4 58
  2. Evidence for a direct role of the disease modifier SCNM1 in splicing. (PMID: 17656373) Howell VM … Meisler MH (Human molecular genetics 2007) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for LUC7L2 Gene

Sources for LUC7L2 Gene

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