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Aliases for ZCCHC17 Gene

Aliases for ZCCHC17 Gene

  • Zinc Finger CCHC-Type Containing 17 2 3 5
  • Zinc Finger CCHC Domain-Containing Protein 17 3 4
  • Pnn-Interacting Nucleolar Protein 3 4
  • PNO40 3 4
  • PS1D 3 4
  • Putative S1 RNA Binding Domain Protein 3
  • Zinc Finger, CCHC Domain Containing 17 3
  • Putative S1 RNA-Binding Domain Protein 4
  • Nucleolar Protein Of 40 KDa 3
  • Nucleolar Protein 40 3
  • PS1D Protein 4
  • HSPC251 3

External Ids for ZCCHC17 Gene

Previous GeneCards Identifiers for ZCCHC17 Gene

  • GC01P031439
  • GC01P031542
  • GC01P031769
  • GC01P029876

Summaries for ZCCHC17 Gene

GeneCards Summary for ZCCHC17 Gene

ZCCHC17 (Zinc Finger CCHC-Type Containing 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Gene Wiki entry for ZCCHC17 Gene

Additional gene information for ZCCHC17 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZCCHC17 Gene

Genomics for ZCCHC17 Gene

GeneHancer (GH) Regulatory Elements for ZCCHC17 Gene

Promoters and enhancers for ZCCHC17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J031295 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.1 -65 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 SNRNP40 ZCCHC17 TXLNA SERINC2 KHDRBS1 KPNA6 TMEM39B EIF3I ENSG00000229447 DCDC2B
GH01J031062 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -232.6 -232563 4.4 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 MEF2D SSRP1 PUM1 KHDRBS1 ENSG00000229447 SNRNP40 COL16A1 ZCCHC17 LAPTM5 GC01P031057
GH01J032262 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +968.4 968406 4.8 ZNF493 ZFP64 RARA ZNF213 SCRT2 ZNF654 ZNF680 ZBTB11 CEBPB ZC3H11A TXLNA KHDRBS1 SNRNP40 RBBP4 ZBTB8A TSSK3 TMEM39B ZNF362 ENSG00000224066 DCDC2B
GH01J031361 Enhancer 0.7 dbSUPER 10.6 +65.4 65441 1.1 ZBTB21 ZFP64 ZNF140 ZNF266 ZNF697 ZNF121 ZNF664 ZNF213 ZNF138 ZNF433 SNRNP40 TXLNA SERINC2 TSSK3 ENSG00000229447 KHDRBS1 TMEM39B ENSG00000224066 DCDC2B ZCCHC17
GH01J031197 Enhancer 0.6 dbSUPER 11.6 -97.6 -97639 3.2 BHLHE40 ZSCAN4 NRF1 ZNF384 MNT GMEB1 POLR2A FOXK2 MYNN KDM1A NKAIN1 SERINC2 SNRNP40 ZCCHC17 ENSG00000229044 GC01M031217 RPL21P22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZCCHC17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZCCHC17 gene promoter:
  • AREB6
  • RORalpha2
  • ISGF-3

Genomic Locations for ZCCHC17 Gene

Genomic Locations for ZCCHC17 Gene
68,741 bases
Plus strand
67,942 bases
Plus strand

Genomic View for ZCCHC17 Gene

Genes around ZCCHC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZCCHC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZCCHC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZCCHC17 Gene

Proteins for ZCCHC17 Gene

  • Protein details for ZCCHC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein of 40 kDa
    Protein Accession:
    Secondary Accessions:
    • B4DY38
    • D3DPN4
    • Q6PKH4
    • Q9NYG4
    • Q9P0M8

    Protein attributes for ZCCHC17 Gene

    241 amino acids
    Molecular mass:
    27570 Da
    Quaternary structure:
    • Interacts with PNN. Associates with the 60S ribosomal subunit (By similarity).
    • Sequence=AAF36171.1; Type=Frameshift; Positions=48; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZCCHC17 Gene

    Alternative splice isoforms for ZCCHC17 Gene


neXtProt entry for ZCCHC17 Gene

Post-translational modifications for ZCCHC17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZCCHC17 Gene

Domains & Families for ZCCHC17 Gene

Gene Families for ZCCHC17 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZCCHC17 Gene

Suggested Antigen Peptide Sequences for ZCCHC17 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZCCHC17: view

No data available for UniProtKB/Swiss-Prot for ZCCHC17 Gene

Function for ZCCHC17 Gene

Phenotypes From GWAS Catalog for ZCCHC17 Gene

Gene Ontology (GO) - Molecular Function for ZCCHC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZCCHC17: view
genes like me logo Genes that share phenotypes with ZCCHC17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZCCHC17

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZCCHC17 Gene

Localization for ZCCHC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZCCHC17 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZCCHC17 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZCCHC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0022625 cytosolic large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with ZCCHC17: view

Pathways & Interactions for ZCCHC17 Gene

SuperPathways for ZCCHC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZCCHC17 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZCCHC17 Gene

Drugs & Compounds for ZCCHC17 Gene

No Compound Related Data Available

Transcripts for ZCCHC17 Gene

Unigene Clusters for ZCCHC17 Gene

Zinc finger, CCHC domain containing 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZCCHC17

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZCCHC17 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP4: -
SP5: -

Relevant External Links for ZCCHC17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZCCHC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZCCHC17 Gene

Protein differential expression in normal tissues from HIPED for ZCCHC17 Gene

This gene is overexpressed in Testis (14.7), Lung (13.9), Retina (11.7), and Pancreatic juice (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZCCHC17 Gene

Protein tissue co-expression partners for ZCCHC17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZCCHC17 Gene:


SOURCE GeneReport for Unigene cluster for ZCCHC17 Gene:


Evidence on tissue expression from TISSUES for ZCCHC17 Gene

  • Muscle(4.5)
  • Kidney(4.4)
  • Blood(4.1)
  • Nervous system(3.1)
  • Heart(2.3)
  • Spleen(2.3)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with ZCCHC17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZCCHC17 Gene

Orthologs for ZCCHC17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZCCHC17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZCCHC17 34 33
  • 99.59 (n)
(Bos Taurus)
Mammalia -- 34
  • 95 (a)
ZCCHC17 34 33
  • 94.74 (n)
(Canis familiaris)
Mammalia ZCCHC17 34 33
  • 94.05 (n)
(Mus musculus)
Mammalia Zcchc17 16 34 33
  • 90.58 (n)
(Rattus norvegicus)
Mammalia Zcchc17 33
  • 89.84 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
-- 34
  • 73 (a)
-- 34
  • 71 (a)
(Gallus gallus)
Aves ZCCHC17 34
  • 74 (a)
(Anolis carolinensis)
Reptilia ZCCHC17 34
  • 65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34048 33
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7227 33
(Danio rerio)
Actinopterygii zcchc17 34
  • 59 (a)
zgc65790 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10823 33
Species where no ortholog for ZCCHC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZCCHC17 Gene

Gene Tree for ZCCHC17 (if available)
Gene Tree for ZCCHC17 (if available)
Evolutionary constrained regions (ECRs) for ZCCHC17: view image

Paralogs for ZCCHC17 Gene Pseudogenes for ZCCHC17 Gene

genes like me logo Genes that share paralogs with ZCCHC17: view

No data available for Paralogs for ZCCHC17 Gene

Variants for ZCCHC17 Gene

Sequence variations from dbSNP and Humsavar for ZCCHC17 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs431905488 not-provided, not provided 31,365,958(+) T/C downstream_transcript_variant
rs483352865 not-provided, not provided 31,365,893(+) T/ downstream_transcript_variant
rs483352875 not-provided, not provided 31,365,952(+) ACA/A downstream_transcript_variant
rs1000006199 -- 31,316,760(+) G/C intron_variant
rs1000045127 -- 31,335,949(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZCCHC17 Gene

Variant ID Type Subtype PubMed ID
esv1665695 CNV insertion 17803354
esv2758930 CNV loss 17122850
esv3585647 CNV loss 21293372
esv3585648 CNV loss 21293372

Variation tolerance for ZCCHC17 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZCCHC17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZCCHC17 Gene

Disorders for ZCCHC17 Gene

Additional Disease Information for ZCCHC17

No disorders were found for ZCCHC17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZCCHC17 Gene

Publications for ZCCHC17 Gene

  1. Molecular characterization of a novel nucleolar protein, pNO40. (PMID: 12893261) Chang WL … Ouyang P (Biochemical and biophysical research communications 2003) 2 3 4 22 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Identification of ribosomal proteins specific to higher eukaryotic organisms. (PMID: 12202495) Gueydan C … Kruys V (The Journal of biological chemistry 2002) 2 3 58

Products for ZCCHC17 Gene

Sources for ZCCHC17 Gene

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