Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHMP5 Gene

Aliases for CHMP5 Gene

  • Charged Multivesicular Body Protein 5 2 3 3 5
  • Vacuolar Protein Sorting-Associated Protein 60 3 4
  • SNF7 Domain-Containing Protein 2 3 4
  • Chromatin-Modifying Protein 5 3 4
  • C9orf83 3 4
  • SNF7DC2 3 4
  • HVps60 3 4
  • Vps60 3 4
  • Chromosome 9 Open Reading Frame 83 2
  • Apoptosis-Related Protein PNAS-2 3
  • Chromatin Modifying Protein 5 2
  • SNF7 Domain Containing 2 3
  • HSPC177 3
  • CGI-34 3
  • PNAS-2 3

External Ids for CHMP5 Gene

Previous HGNC Symbols for CHMP5 Gene

  • C9orf83
  • SNF7DC2

Summaries for CHMP5 Gene

Entrez Gene Summary for CHMP5 Gene

  • CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CHMP5 Gene

CHMP5 (Charged Multivesicular Body Protein 5) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Vesicle-mediated transport.

UniProtKB/Swiss-Prot for CHMP5 Gene

  • Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Gene Wiki entry for CHMP5 Gene

Additional gene information for CHMP5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP5 Gene

Genomics for CHMP5 Gene

GeneHancer (GH) Regulatory Elements for CHMP5 Gene

Promoters and enhancers for CHMP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J033262 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.4 -394 3.6 HDGF FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 IRF4 YY1 BAG1 CHMP5 GC09M033264 NFX1 GC09M033252 GC09M033167 GC09M033168 GC09M033166
GH09J033286 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12 +28.2 28248 13 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D NFX1 PIR32325 B4GALT1 BAG1 ENSG00000228352 DFFBP1 ANXA2P2 SMU1 CHMP5 DDX58
GH09J033075 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.1 -188.4 -188406 2.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 SMU1 NOL6 NFX1 ASS1P12 B4GALT1 TOPORS ANXA2P2 TCEA1P4 DFFBP1 UBAP2
GH09J033239 Promoter/Enhancer 1.4 EPDnew ENCODE 12.6 -24.7 -24706 1.3 PKNOX1 SMAD1 ATF1 ARNT ARID4B TCF12 ZNF766 GATA2 ATF7 NCOA1 SPINK4 BAG1 CHMP5 SMU1 B4GALT1 B4GALT1-AS1 RNU4ATAC15P NFX1 GC09P033251 GC09M033167
GH09J033226 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.5 -32.9 -32888 11 PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A ZBTB7B IRF4 BRCA1 ZNF121 NFX1 SMU1 BAG1 ASS1P12 DFFBP1 TCEA1P4 TOPORS ENSG00000228352 CHMP5 NOL6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHMP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHMP5 gene promoter:
  • GR
  • GR-alpha
  • RFX1
  • ATF6
  • ER-alpha
  • POU2F1
  • POU2F1a
  • Evi-1
  • LHX3b
  • Lhx3a

Genomic Locations for CHMP5 Gene

Genomic Locations for CHMP5 Gene
chr9:33,264,879-33,282,069
(GRCh38/hg38)
Size:
17,191 bases
Orientation:
Plus strand
chr9:33,264,877-33,282,067
(GRCh37/hg19)
Size:
17,191 bases
Orientation:
Plus strand

Genomic View for CHMP5 Gene

Genes around CHMP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHMP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHMP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP5 Gene

Proteins for CHMP5 Gene

  • Protein details for CHMP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZZ3-CHMP5_HUMAN
    Recommended name:
    Charged multivesicular body protein 5
    Protein Accession:
    Q9NZZ3
    Secondary Accessions:
    • B2RD95
    • B4DIR6
    • Q5VXW2
    • Q96AV2
    • Q9HB68
    • Q9NYS4
    • Q9Y323

    Protein attributes for CHMP5 Gene

    Size:
    219 amino acids
    Molecular mass:
    24571 Da
    Quaternary structure:
    • Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with VTA1. Interacts with CHMP2A. Interacts with VTA1; the interaction involves soluble CHMP5.
    SequenceCaution:
    • Sequence=AAG23821.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHMP5 Gene

    Alternative splice isoforms for CHMP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHMP5 Gene

Post-translational modifications for CHMP5 Gene

  • ISGylated. Isgylation inhibits its interaction with VTA1.
  • Ubiquitination at posLast=100100
  • Modification sites at PhosphoSitePlus

Other Protein References for CHMP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHMP5 Gene

Domains & Families for CHMP5 Gene

Gene Families for CHMP5 Gene

Protein Domains for CHMP5 Gene

Suggested Antigen Peptide Sequences for CHMP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZZ3

UniProtKB/Swiss-Prot:

CHMP5_HUMAN :
  • Belongs to the SNF7 family.
Family:
  • Belongs to the SNF7 family.
genes like me logo Genes that share domains with CHMP5: view

Function for CHMP5 Gene

Molecular function for CHMP5 Gene

UniProtKB/Swiss-Prot Function:
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Phenotypes From GWAS Catalog for CHMP5 Gene

Gene Ontology (GO) - Molecular Function for CHMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15644320
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with CHMP5: view
genes like me logo Genes that share phenotypes with CHMP5: view

Animal Models for CHMP5 Gene

MGI Knock Outs for CHMP5:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHMP5 Gene

Localization for CHMP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP5 Gene

Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHMP5 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
endosome 4
cytoskeleton 2
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Midbody (3)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with CHMP5: view

Pathways & Interactions for CHMP5 Gene

genes like me logo Genes that share pathways with CHMP5: view

Pathways by source for CHMP5 Gene

Gene Ontology (GO) - Biological Process for CHMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0001919 regulation of receptor recycling IEA --
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport IEA --
GO:0007040 lysosome organization IEA --
genes like me logo Genes that share ontologies with CHMP5: view

No data available for SIGNOR curated interactions for CHMP5 Gene

Drugs & Compounds for CHMP5 Gene

No Compound Related Data Available

Transcripts for CHMP5 Gene

mRNA/cDNA for CHMP5 Gene

Unigene Clusters for CHMP5 Gene

Charged multivesicular body protein 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for CHMP5 Gene

GeneLoc Exon Structure for
CHMP5
ECgene alternative splicing isoforms for
CHMP5

Expression for CHMP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHMP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CHMP5 Gene

This gene is overexpressed in Urine (35.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHMP5 Gene



Protein tissue co-expression partners for CHMP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHMP5 Gene:

CHMP5

SOURCE GeneReport for Unigene cluster for CHMP5 Gene:

Hs.635313

Evidence on tissue expression from TISSUES for CHMP5 Gene

  • Nervous system(4.9)
  • Bone marrow(4.4)
  • Kidney(4.4)
  • Liver(4.3)
  • Blood(4.2)
  • Lung(2.2)
  • Spleen(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with CHMP5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHMP5 Gene

Orthologs for CHMP5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHMP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHMP5 34 33
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CHMP5 34 33
  • 93.91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CHMP5 34 33
  • 93.61 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHMP5 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHMP5 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chmp5 33
  • 88.28 (n)
mouse
(Mus musculus)
Mammalia Chmp5 16 34 33
  • 87.82 (n)
chicken
(Gallus gallus)
Aves CHMP5 34 33
  • 81.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHMP5 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chmp5 33
  • 79.3 (n)
African clawed frog
(Xenopus laevis)
Amphibia hspc177-prov 33
zebrafish
(Danio rerio)
Actinopterygii chmp5b 34 33
  • 73.97 (n)
OneToMany
chmp5a 34
  • 67 (a)
OneToMany
zgc64125 33
fruit fly
(Drosophila melanogaster)
Insecta CG6259 34 33
  • 62.25 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005100 33
  • 61.8 (n)
worm
(Caenorhabditis elegans)
Secernentea F41E6.9 33
  • 61.11 (n)
vps-60 34
  • 57 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03608g 33
  • 50.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS60 36 34 33
  • 49.76 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR116C 33
  • 47.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS60.2 33
  • 53.99 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9203 33
rice
(Oryza sativa)
Liliopsida Os05g0102900 33
  • 52.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
OneToOne
Cin.5195 33
bread mold
(Neurospora crassa)
Ascomycetes NCU04541 33
  • 54.76 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC162.06c 33
  • 50.82 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5195 33
Species where no ortholog for CHMP5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHMP5 Gene

ENSEMBL:
Gene Tree for CHMP5 (if available)
TreeFam:
Gene Tree for CHMP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHMP5: view image

Paralogs for CHMP5 Gene

Pseudogenes.org Pseudogenes for CHMP5 Gene

genes like me logo Genes that share paralogs with CHMP5: view

No data available for Paralogs for CHMP5 Gene

Variants for CHMP5 Gene

Sequence variations from dbSNP and Humsavar for CHMP5 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000011527 -- 33,269,702(+) C/T intron_variant
rs1000127245 -- 33,280,399(+) C/G intron_variant
rs1000234535 -- 33,263,396(+) C/G upstream_transcript_variant
rs1000289708 -- 33,276,647(+) G/T intron_variant
rs1000510498 -- 33,269,429(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHMP5 Gene

Variant ID Type Subtype PubMed ID
dgv7516n100 CNV gain 25217958
nsv519369 CNV gain 19592680
nsv614146 CNV gain 21841781

Variation tolerance for CHMP5 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHMP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHMP5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHMP5 Gene

Disorders for CHMP5 Gene

Additional Disease Information for CHMP5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CHMP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHMP5 Gene

Publications for CHMP5 Gene

  1. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. (PMID: 15644320) Ward DM … Kaplan J (The Journal of biological chemistry 2005) 2 3 4 58
  2. Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15. (PMID: 21543490) Kuang Z … Leis J (Journal of virology 2011) 3 4 58
  3. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns SL … Rosenstein BS (International journal of radiation oncology, biology, physics 2010) 3 44 58
  4. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. (PMID: 17261583) Ma YM … Kirchhausen T (The Journal of biological chemistry 2007) 3 4 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58

Products for CHMP5 Gene

Sources for CHMP5 Gene

Content
Loading form....