Aliases for REV1 Gene
External Ids for REV1 Gene
Previous HGNC Symbols for REV1 Gene
Previous GeneCards Identifiers for REV1 Gene
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
GeneCards Summary for REV1 Gene
REV1 (REV1, DNA Directed Polymerase) is a Protein Coding gene. Diseases associated with REV1 include Leber Congenital Amaurosis 2 and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and DNA-directed DNA polymerase activity. An important paralog of this gene is POLK.
UniProtKB/Swiss-Prot for REV1 Gene
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.