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Aliases for ANGPT4 Gene

Aliases for ANGPT4 Gene

  • Angiopoietin 4 2 3 5
  • ANG3 3 4
  • ANG4 3 4
  • Angiopoietin-4 3
  • Angiopoietin-3 4
  • ANG-3 4
  • ANG-4 4

External Ids for ANGPT4 Gene

Previous GeneCards Identifiers for ANGPT4 Gene

  • GC20M000841
  • GC20M000848
  • GC20M000801
  • GC20M000805
  • GC20M000853

Summaries for ANGPT4 Gene

Entrez Gene Summary for ANGPT4 Gene

  • Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANGPT4 Gene

ANGPT4 (Angiopoietin 4) is a Protein Coding gene. Among its related pathways are Akt Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include receptor tyrosine kinase binding and transmembrane receptor protein tyrosine kinase activator activity. An important paralog of this gene is ANGPT1.

UniProtKB/Swiss-Prot for ANGPT4 Gene

  • Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Gene Wiki entry for ANGPT4 Gene

Additional gene information for ANGPT4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPT4 Gene

Genomics for ANGPT4 Gene

GeneHancer (GH) Regulatory Elements for ANGPT4 Gene

Promoters and enhancers for ANGPT4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J000917 Promoter 0.5 EPDnew 650.7 +0.0 21 0.1 ANGPT4 LOC105372492
GH20J000914 Enhancer 0.3 Ensembl 650.7 +1.4 1374 0.4 NFE2 ANGPT4 LOC105372492
GH20J000916 Enhancer 0.2 Ensembl 650.7 +0.3 274 0.2 ANGPT4 LOC105372492
GH20J000840 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 10.8 +71.8 71755 7.5 ELF3 SIN3A ZNF335 GLIS2 ELK1 RCOR1 CREM EGR2 SP3 CEBPB FAM110A PIR36894 ANGPT4 RSPO4 RPS10P5 GC20M000847 PIR34196
GH20J000766 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 10.4 +147.6 147625 3.5 ATF1 KLF17 ZBTB40 RAD21 ETS1 ZNF143 FOS ATF7 CREM THAP11 SLC52A3 TBC1D20 RBCK1 RSPO4 ANGPT4 GC20P000743
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANGPT4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANGPT4 gene promoter:
  • FAC1
  • Evi-1
  • AP-4
  • STAT5B
  • FOXJ2
  • FOXJ2 (long isoform)
  • LUN-1
  • C/EBPbeta
  • Nkx3-1 v4
  • Nkx3-1 v3

Genomic Locations for ANGPT4 Gene

Genomic Locations for ANGPT4 Gene
46,477 bases
Minus strand
43,682 bases
Minus strand

Genomic View for ANGPT4 Gene

Genes around ANGPT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPT4 Gene

Proteins for ANGPT4 Gene

  • Protein details for ANGPT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4E3J9
    • Q5TFF4
    • Q9H4Z4

    Protein attributes for ANGPT4 Gene

    503 amino acids
    Molecular mass:
    56849 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with TEK/TIE2.

    Alternative splice isoforms for ANGPT4 Gene


neXtProt entry for ANGPT4 Gene

Post-translational modifications for ANGPT4 Gene

  • Glycosylation at posLast=427427, posLast=337337, Asn311, Asn274, posLast=247247, posLast=158158, posLast=140140, posLast=126126, and posLast=9696
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANGPT4 Gene

Domains & Families for ANGPT4 Gene

Gene Families for ANGPT4 Gene

Suggested Antigen Peptide Sequences for ANGPT4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANGPT4: view

No data available for UniProtKB/Swiss-Prot for ANGPT4 Gene

Function for ANGPT4 Gene

Molecular function for ANGPT4 Gene

UniProtKB/Swiss-Prot Function:
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
GENATLAS Biochemistry:
angiopoietin 4 secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK,including phosphorylation of TEK,promoting angiogenic remodeling as well as vessel maturation and stabilization,predominantly expressed in lung

Phenotypes From GWAS Catalog for ANGPT4 Gene

Gene Ontology (GO) - Molecular Function for ANGPT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity IDA 10051567
GO:0030971 receptor tyrosine kinase binding IDA 10051567
genes like me logo Genes that share ontologies with ANGPT4: view
genes like me logo Genes that share phenotypes with ANGPT4: view

Animal Model Products

miRNA for ANGPT4 Gene

miRTarBase miRNAs that target ANGPT4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANGPT4 Gene

Localization for ANGPT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPT4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPT4 gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ANGPT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10025962
genes like me logo Genes that share ontologies with ANGPT4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ANGPT4 Gene

Pathways & Interactions for ANGPT4 Gene

genes like me logo Genes that share pathways with ANGPT4: view

SIGNOR curated interactions for ANGPT4 Gene


Gene Ontology (GO) - Biological Process for ANGPT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001935 NOT endothelial cell proliferation IDA 10025962
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0010595 positive regulation of endothelial cell migration IDA 12958144
genes like me logo Genes that share ontologies with ANGPT4: view

Drugs & Compounds for ANGPT4 Gene

(1) Drugs for ANGPT4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ANGPT4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANGPT4: view

Transcripts for ANGPT4 Gene

mRNA/cDNA for ANGPT4 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANGPT4 Gene

Angiopoietin 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPT4 Gene

No ASD Table

Relevant External Links for ANGPT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGPT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGPT4 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPT4 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.8), Adipose - Visceral (Omentum) (x5.1), Breast - Mammary Tissue (x4.3), and Cervix - Endocervix (x4.1).

Protein differential expression in normal tissues from HIPED for ANGPT4 Gene

This gene is overexpressed in Placenta (59.6) and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPT4 Gene

Protein tissue co-expression partners for ANGPT4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANGPT4 Gene:


SOURCE GeneReport for Unigene cluster for ANGPT4 Gene:


mRNA Expression by UniProt/SwissProt for ANGPT4 Gene:

Tissue specificity: Highly expressed in the lung with much lower levels found in other tissues.
genes like me logo Genes that share expression patterns with ANGPT4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPT4 Gene

Orthologs for ANGPT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANGPT4 34 33
  • 97.36 (n)
(Canis familiaris)
Mammalia ANGPT4 34 33
  • 81.12 (n)
(Bos Taurus)
Mammalia ANGPT4 33
  • 80.99 (n)
  • 68 (a)
(Rattus norvegicus)
Mammalia Angpt4 33
  • 71.7 (n)
(Mus musculus)
Mammalia Angpt4 16 34 33
  • 70.82 (n)
(Monodelphis domestica)
Mammalia ANGPT4 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 24 (a)
(Gallus gallus)
Aves ANGPT4 34 33
  • 68.53 (n)
(Anolis carolinensis)
Reptilia ANGPT4 34
  • 55 (a)
(Danio rerio)
Actinopterygii angpt4 34
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10359 35
  • 38 (a)
CG9500 35
  • 38 (a)
sca 35
  • 27 (a)
Species where no ortholog for ANGPT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPT4 Gene

Gene Tree for ANGPT4 (if available)
Gene Tree for ANGPT4 (if available)
Evolutionary constrained regions (ECRs) for ANGPT4: view image

Paralogs for ANGPT4 Gene

(12) SIMAP similar genes for ANGPT4 Gene using alignment to 2 proteins:

  • B4E3J9_HUMAN
genes like me logo Genes that share paralogs with ANGPT4: view

Variants for ANGPT4 Gene

Sequence variations from dbSNP and Humsavar for ANGPT4 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000034916 -- 909,610(-) T/G intron_variant
rs1000065959 -- 907,468(-) G/C intron_variant
rs1000100866 -- 871,723(-) G/A 3_prime_UTR_variant
rs1000148070 -- 907,320(-) A/G intron_variant
rs1000159103 -- 897,593(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPT4 Gene

Variant ID Type Subtype PubMed ID
esv274947 CNV gain+loss 21479260
esv3575346 CNV gain 25503493
esv3584405 CNV loss 25503493
esv3644952 CNV gain 21293372
esv3644964 CNV gain 21293372
esv3644966 CNV gain 21293372
nsv1058339 CNV loss 25217958
nsv1062082 CNV gain 25217958
nsv1062764 CNV loss 25217958
nsv1067424 CNV gain 25217958
nsv458848 CNV loss 19166990
nsv510778 CNV deletion 20534489
nsv585191 CNV gain 21841781
nsv585193 CNV gain 21841781
nsv585194 CNV loss 21841781
nsv817879 CNV gain 17921354

Variation tolerance for ANGPT4 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANGPT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPT4 Gene

Disorders for ANGPT4 Gene

Additional Disease Information for ANGPT4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANGPT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPT4 Gene

Publications for ANGPT4 Gene

  1. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (PMID: 10051567) Valenzuela DM … Yancopoulos GD (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 22 58
  2. Biological characterization of angiopoietin-3 and angiopoietin-4. (PMID: 15284220) Lee HJ … Koh GY (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004) 3 4 22 58
  3. Angiopoietin-3, a novel member of the angiopoietin family. (PMID: 10218486) Nishimura M … Seino S (FEBS letters 1999) 2 3 4 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58

Products for ANGPT4 Gene

Sources for ANGPT4 Gene

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