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Aliases for PDE1A Gene

Aliases for PDE1A Gene

  • Phosphodiesterase 1A 2 3 5
  • Phosphodiesterase 1A, Calmodulin-Dependent 2 3
  • 61 KDa Cam-PDE 3 4
  • Cam-PDE 1A 3 4
  • Calcium/Calmodulin-Dependent 3,5-Cyclic Nucleotide Phosphodiesterase 1A 3
  • Calcium/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 3
  • EC 4
  • CAM-PDE-1A 3
  • HSPDE1A 3
  • HCAM-1 3
  • HCam-1 4
  • HCAM1 3

External Ids for PDE1A Gene

Previous GeneCards Identifiers for PDE1A Gene

  • GC02M181214
  • GC02M181690
  • GC02M182971
  • GC02M183209
  • GC02M182832
  • GC02M182715
  • GC02M174863

Summaries for PDE1A Gene

Entrez Gene Summary for PDE1A Gene

  • Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

GeneCards Summary for PDE1A Gene

PDE1A (Phosphodiesterase 1A) is a Protein Coding gene. Among its related pathways are G-Beta Gamma Signaling and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include calmodulin binding and cGMP binding. An important paralog of this gene is PDE1C.

UniProtKB/Swiss-Prot for PDE1A Gene

  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.

Tocris Summary for PDE1A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE1A Gene

Additional gene information for PDE1A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE1A Gene

Genomics for PDE1A Gene

GeneHancer (GH) Regulatory Elements for PDE1A Gene

Promoters and enhancers for PDE1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J182426 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.2 +96.5 96528 1.3 ZNF335 HLF MYNN ZNF10 ZBTB17 PDE1A PIR50077 GC02P182516
GH02J182522 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 655.3 +0.3 280 1 OSR2 ZSCAN21 POLR2A SCRT2 PRDM10 PRDM1 PDE1A GC02M182521
GH02J182714 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 -193.5 -193476 3.9 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B DNAJC10 NCKAP1 NUP35 PDE1A FRZB GC02P182762
GH02J182504 Enhancer 0.5 ENCODE 7.6 +18.1 18143 0.2 JUND CEBPB FOS NR2F2 PDE1A GC02P182516 PIR50077
GH02J182143 Enhancer 0.4 ENCODE 6 +378.6 378618 1.2 STAT1 CEBPB PDE1A GC02M182141 RN7SL267P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PDE1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDE1A gene promoter:
  • FOXO1a
  • FOXO1
  • Sox5
  • POU2F1a
  • POU2F1

Genomic Locations for PDE1A Gene

Genomic Locations for PDE1A Gene
383,158 bases
Minus strand
383,157 bases
Minus strand

Genomic View for PDE1A Gene

Genes around PDE1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE1A Gene

Proteins for PDE1A Gene

  • Protein details for PDE1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1A
    Protein Accession:
    Secondary Accessions:
    • D3DPG5
    • Q86VZ0
    • Q9C0K8
    • Q9C0K9
    • Q9C0L0
    • Q9C0L1
    • Q9C0L2
    • Q9C0L3
    • Q9C0L4
    • Q9UFX3

    Protein attributes for PDE1A Gene

    535 amino acids
    Molecular mass:
    61252 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PDE1A Gene

    Alternative splice isoforms for PDE1A Gene

neXtProt entry for PDE1A Gene

Post-translational modifications for PDE1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PDE1A Gene

Domains & Families for PDE1A Gene

Gene Families for PDE1A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PDE1A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
genes like me logo Genes that share domains with PDE1A: view

Function for PDE1A Gene

Molecular function for PDE1A Gene

UniProtKB/Swiss-Prot Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).

Enzyme Numbers (IUBMB) for PDE1A Gene

Phenotypes From GWAS Catalog for PDE1A Gene

Gene Ontology (GO) - Molecular Function for PDE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity TAS --
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS --
GO:0005516 calmodulin binding IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PDE1A: view
genes like me logo Genes that share phenotypes with PDE1A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PDE1A

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE1A

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDE1A Gene

Localization for PDE1A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE1A gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PDE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PDE1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE1A Gene

Pathways & Interactions for PDE1A Gene

genes like me logo Genes that share pathways with PDE1A: view

Interacting Proteins for PDE1A Gene

Gene Ontology (GO) - Biological Process for PDE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0034391 regulation of smooth muscle cell apoptotic process IEA --
GO:0046069 cGMP catabolic process IEA --
genes like me logo Genes that share ontologies with PDE1A: view

No data available for SIGNOR curated interactions for PDE1A Gene

Drugs & Compounds for PDE1A Gene

(20) Drugs for PDE1A Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bepridil Approved, Withdrawn Pharma Pore Blocker, Target, inhibitor 0
Felodipine Approved, Investigational Pharma Potentiation, Activator, Target, inhibitor 22
Nicardipine Approved, Investigational Pharma Antagonist, Target, inhibitor 33
Trapidil Approved Pharma Target, inhibitor 1
Caffeine Approved Nutra Antagonist, Activator, Target, inhibitor 434

(7) Additional Compounds for PDE1A Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Etazolate hydrochloride
Antagonist 28822-58-4
Ro 20-1724

(5) Tocris Compounds for PDE1A Gene

Compound Action Cas Number
Eggmanone Potent and selective PDE4 inhibitor; suppresses hedgehog signaling 505068-32-6
Etazolate hydrochloride PDE4 inhibitor 35838-58-5
IBMX PDE inhibitor (non-selective) 28822-58-4
MY-5445 PDE5 inhibitor 78351-75-4
Ro 20-1724 PDE4 inhibitor 29925-17-5
genes like me logo Genes that share compounds with PDE1A: view

Transcripts for PDE1A Gene

Unigene Clusters for PDE1A Gene

Phosphodiesterase 1A, calmodulin-dependent:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PDE1A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE1A Gene

No ASD Table

Relevant External Links for PDE1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDE1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDE1A Gene

mRNA differential expression in normal tissues according to GTEx for PDE1A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.1).

Protein differential expression in normal tissues from HIPED for PDE1A Gene

This gene is overexpressed in Frontal cortex (27.7), Brain (15.1), Fetal Brain (10.9), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDE1A Gene

Protein tissue co-expression partners for PDE1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PDE1A Gene:


SOURCE GeneReport for Unigene cluster for PDE1A Gene:


mRNA Expression by UniProt/SwissProt for PDE1A Gene:

Tissue specificity: Several tissues, including brain, kidney, testes and heart.

Evidence on tissue expression from TISSUES for PDE1A Gene

  • Nervous system(4.9)
  • Heart(4.4)
  • Kidney(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PDE1A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE1A Gene

Orthologs for PDE1A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDE1A 34 33
  • 99.76 (n)
(Canis familiaris)
Mammalia PDE1A 34 33
  • 92.11 (n)
(Bos Taurus)
Mammalia PDE1A 34 33
  • 91.95 (n)
(Rattus norvegicus)
Mammalia Pde1a 33
  • 88.72 (n)
(Mus musculus)
Mammalia Pde1a 16 34 33
  • 88.34 (n)
(Monodelphis domestica)
Mammalia PDE1A 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia PDE1A 34
  • 77 (a)
(Gallus gallus)
Aves PDE1A 34 33
  • 78.37 (n)
(Anolis carolinensis)
Reptilia PDE1A 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pde1a 33
  • 74.79 (n)
(Danio rerio)
Actinopterygii pde1a 34 33
  • 69.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008967 33
  • 56.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pde1c 34 33
  • 55.16 (n)
CG14940 35
  • 54 (a)
(Caenorhabditis elegans)
Secernentea T04D3.3 35
  • 54 (a)
pde-1 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
Species where no ortholog for PDE1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE1A Gene

Gene Tree for PDE1A (if available)
Gene Tree for PDE1A (if available)
Evolutionary constrained regions (ECRs) for PDE1A: view image

Paralogs for PDE1A Gene

(9) SIMAP similar genes for PDE1A Gene using alignment to 8 proteins:

  • B7Z3A7_HUMAN
  • Q53T15_HUMAN
  • Q53TB0_HUMAN
  • Q9Y246_HUMAN
  • Q9Y633_HUMAN
  • Q9Y634_HUMAN
genes like me logo Genes that share paralogs with PDE1A: view

Variants for PDE1A Gene

Sequence variations from dbSNP and Humsavar for PDE1A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000006576 -- 182,255,401(-) T/C/G genic_upstream_transcript_variant, intron_variant
rs1000009295 -- 182,299,020(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000014123 -- 182,205,254(-) T/C intron_variant
rs1000019832 -- 182,500,101(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000021541 -- 182,254,661(-) ATGAT/AT genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDE1A Gene

Variant ID Type Subtype PubMed ID
dgv2108n106 CNV deletion 24896259
dgv2109n106 CNV deletion 24896259
dgv479n27 CNV gain 19166990
dgv682n67 CNV gain 20364138
dgv7212n54 CNV loss 21841781
esv1007075 CNV deletion 20482838
esv2241730 CNV deletion 18987734
esv2279238 CNV deletion 18987734
esv2343576 CNV deletion 18987734
esv2433646 CNV deletion 19546169
esv2465768 CNV deletion 19546169
esv2479479 CNV deletion 19546169
esv2673668 CNV deletion 23128226
esv2675520 CNV deletion 23128226
esv2677830 CNV deletion 23128226
esv2721209 CNV deletion 23290073
esv2721210 CNV deletion 23290073
esv2721211 CNV deletion 23290073
esv2721212 CNV deletion 23290073
esv2721213 CNV deletion 23290073
esv2721214 CNV deletion 23290073
esv27621 CNV loss 19812545
esv2762981 CNV loss 21179565
esv2874 CNV loss 18987735
esv3023397 CNV deletion 24192839
esv3560646 CNV deletion 23714750
esv3560647 CNV deletion 23714750
esv3584216 CNV loss 25503493
esv3584217 CNV loss 25503493
esv3584218 CNV loss 25503493
esv3584219 CNV loss 25503493
esv3593559 CNV gain 21293372
esv3593560 CNV loss 21293372
esv3593561 CNV loss 21293372
esv3593563 CNV loss 21293372
esv3593564 CNV loss 21293372
esv3593565 CNV loss 21293372
esv7845 CNV loss 19470904
nsv1009882 CNV gain 25217958
nsv1072471 CNV deletion 25765185
nsv1138872 CNV deletion 24896259
nsv1149683 CNV duplication 26484159
nsv215323 CNV deletion 16902084
nsv3064 CNV insertion 18451855
nsv478225 CNV novel sequence insertion 20440878
nsv516110 CNV loss 19592680
nsv583913 CNV loss 21841781
nsv583916 CNV gain 21841781
nsv821840 CNV gain 20364138
nsv834481 CNV gain 17160897
nsv954721 CNV deletion 24416366

Variation tolerance for PDE1A Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDE1A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE1A Gene

Disorders for PDE1A Gene

Additional Disease Information for PDE1A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PDE1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDE1A Gene

Publications for PDE1A Gene

  1. Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization. (PMID: 11342109) Michibata H … Omori K (Biochimica et biophysica acta 2001) 2 3 4 22 58
  2. Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. (PMID: 8557689) Loughney K … Ferguson K (The Journal of biological chemistry 1996) 2 3 4 22 58
  3. Association of PDE11A global haplotype with major depression and antidepressant drug response. (PMID: 19557111) Luo HR … Wong ML (Neuropsychiatric disease and treatment 2009) 3 22 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for PDE1A Gene

Sources for PDE1A Gene

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