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Aliases for TLR7 Gene

Aliases for TLR7 Gene

  • Toll Like Receptor 7 2 3 5
  • Toll-Like Receptor 7 2 3
  • Toll-Like Receptor 7-Like 3
  • TLR7-Like 3

External Ids for TLR7 Gene

Previous GeneCards Identifiers for TLR7 Gene

  • GC0XP012078
  • GC0XP011651
  • GC0XP012181
  • GC0XP012246
  • GC0XP012644
  • GC0XP012795
  • GC0XP010651
  • GC0XP012885

Summaries for TLR7 Gene

Entrez Gene Summary for TLR7 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR7 Gene

TLR7 (Toll Like Receptor 7) is a Protein Coding gene. Diseases associated with TLR7 include Superficial Basal Cell Carcinoma and Anogenital Venereal Wart. Among its related pathways are Toll-like receptor signaling pathway and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and double-stranded RNA binding. An important paralog of this gene is TLR8.

UniProtKB/Swiss-Prot for TLR7 Gene

  • Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Tocris Summary for TLR7 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.

Gene Wiki entry for TLR7 Gene

Additional gene information for TLR7 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR7 Gene

Genomics for TLR7 Gene

GeneHancer (GH) Regulatory Elements for TLR7 Gene

Promoters and enhancers for TLR7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI012866 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 556.6 +0.6 644 2.9 SRF PKNOX1 JUNB EBF1 DPF2 BATF RELA ZNF217 HDAC2 POLR2A TLR7 GC0XP012877 GC0XP012878
GH0XI012865 Enhancer 0.5 Ensembl 556.5 -1.4 -1394 0.6 IRF9 ATF4 IKZF1 CEBPB CEBPG TLR7 MRPL35P4
GH0XI012842 Enhancer 1 Ensembl ENCODE 13.9 -23.0 -22979 2.7 ELF3 PKNOX1 FOXA2 ARID4B DMAP1 ZSCAN9 RARA SMARCC2 ATF7 CREM MRPL35P4 TLR7 PSMA6P2
GH0XI012889 Enhancer 0.9 Ensembl ENCODE 12.9 +24.4 24387 4.1 HDGF PKNOX1 RELA NFATC1 ATF7 ZSCAN29 PRDM10 BCLAF1 IKZF2 RUNX3 TLR7 TLR8-AS1 GC0XP012877 GC0XP012878 TLR8
GH0XI012894 Enhancer 0.8 FANTOM5 ENCODE 12.9 +27.3 27288 0.4 CTCF ZNF654 RB1 TRIM22 RAD21 TARDBP NBN ZNF143 SMC3 RUNX3 TLR7 TLR8-AS1 TLR8 GC0XP012877 GC0XP012878
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TLR7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLR7 gene promoter:

Genomic Locations for TLR7 Gene

Genomic Locations for TLR7 Gene
chrX:12,867,083-12,890,380
(GRCh38/hg38)
Size:
23,298 bases
Orientation:
Plus strand
chrX:12,885,202-12,908,499
(GRCh37/hg19)

Genomic View for TLR7 Gene

Genes around TLR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR7 Gene

Proteins for TLR7 Gene

  • Protein details for TLR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYK1-TLR7_HUMAN
    Recommended name:
    Toll-like receptor 7
    Protein Accession:
    Q9NYK1
    Secondary Accessions:
    • D1CS69
    • Q9NR98

    Protein attributes for TLR7 Gene

    Size:
    1049 amino acids
    Molecular mass:
    120922 Da
    Quaternary structure:
    • Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Interacts with SMPDL3B (By similarity).

neXtProt entry for TLR7 Gene

Post-translational modifications for TLR7 Gene

  • Glycosylation at posLast=6666, isoforms=69, posLast=167167, posLast=202202, isoforms=215, isoforms=361, posLast=413413, isoforms=488, isoforms=523, posLast=534534, posLast=590590, isoforms=679, isoforms=720, and posLast=799799

Other Protein References for TLR7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLR7 Gene

Domains & Families for TLR7 Gene

Gene Families for TLR7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TLR7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYK1

UniProtKB/Swiss-Prot:

TLR7_HUMAN :
  • Belongs to the Toll-like receptor family.
Family:
  • Belongs to the Toll-like receptor family.
genes like me logo Genes that share domains with TLR7: view

Function for TLR7 Gene

Molecular function for TLR7 Gene

UniProtKB/Swiss-Prot Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Phenotypes From GWAS Catalog for TLR7 Gene

Gene Ontology (GO) - Molecular Function for TLR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 16111635
GO:0003727 single-stranded RNA binding ISS --
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0008144 drug binding IEA --
GO:0035197 siRNA binding IEA,ISS --
genes like me logo Genes that share ontologies with TLR7: view
genes like me logo Genes that share phenotypes with TLR7: view

Animal Models for TLR7 Gene

MGI Knock Outs for TLR7:

Clone Products

  • Addgene plasmids for TLR7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR7 Gene

Localization for TLR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR7 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250 UniProtKB:P58681}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLR7 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
lysosome 5
endosome 5
golgi apparatus 4
extracellular 2
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TLR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IDA 19740627
GO:0005764 lysosome ISS --
GO:0005768 endosome ISS --
GO:0005783 endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with TLR7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TLR7 Gene

Pathways & Interactions for TLR7 Gene

genes like me logo Genes that share pathways with TLR7: view

Gene Ontology (GO) - Biological Process for TLR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0002224 toll-like receptor signaling pathway TAS,IEA --
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with TLR7: view

No data available for SIGNOR curated interactions for TLR7 Gene

Drugs & Compounds for TLR7 Gene

(25) Drugs for TLR7 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Imiquimod Approved, Investigational Pharma Agonist, Target, agonist TLR-7 agonist,immunomodulator with antiviral and antitumor activity 148
Hydroxychloroquine Approved Pharma Target, antagonist, inhibitor Autophagy inhibitor 167
Edetic Acid Approved, Vet_approved Pharma 114
ANA971 Investigational Pharma Target 0
Golotimod Investigational Pharma Target 0

(5) Additional Compounds for TLR7 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
R848
Agonist

(5) Tocris Compounds for TLR7 Gene

Compound Action Cas Number
Imiquimod Toll-like receptor 7 (TLR7) agonist 99011-02-6
Pam3CSK4 TLR1/2 agonist; induces cytokine production 112208-00-1
Poly(I:C) TLR3 agonist 24939-03-5
Resiquimod Toll-like receptor 7 (TLR7) agonist 144875-48-9
RWJ 21757 Toll-like receptor 7 (TLR7) agonist 121288-39-9

(5) ApexBio Compounds for TLR7 Gene

Compound Action Cas Number
Hydroxychloroquine Sulfate 747-36-4
Imiquimod TLR-7 agonist,immunomodulator with antiviral and antitumor activity 99011-02-6
Imiquimod hydrochloride Toll-like receptor 7 agonist 99011-78-6
Imiquimod maleate Immune response modifier 896106-16-4
Resiquimod (R-848) Immune response modifier 144875-48-9
genes like me logo Genes that share compounds with TLR7: view

Drug Products

Transcripts for TLR7 Gene

mRNA/cDNA for TLR7 Gene

Unigene Clusters for TLR7 Gene

Toll-like receptor 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for TLR7

Alternative Splicing Database (ASD) splice patterns (SP) for TLR7 Gene

No ASD Table

Relevant External Links for TLR7 Gene

GeneLoc Exon Structure for
TLR7
ECgene alternative splicing isoforms for
TLR7

Expression for TLR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TLR7 Gene

This gene is overexpressed in Testis (58.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLR7 Gene



Protein tissue co-expression partners for TLR7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TLR7 Gene:

TLR7

SOURCE GeneReport for Unigene cluster for TLR7 Gene:

Hs.659215

mRNA Expression by UniProt/SwissProt for TLR7 Gene:

Q9NYK1-TLR7_HUMAN
Tissue specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Evidence on tissue expression from TISSUES for TLR7 Gene

  • Lymph node(3.6)
  • Spleen(3.6)
  • Blood(3.5)
  • Liver(2.2)
  • Lung(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with TLR7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR7 Gene

Orthologs for TLR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR7 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia TLR7 33 34
  • 87.5 (n)
dog
(Canis familiaris)
Mammalia TLR7 33 34
  • 86.91 (n)
rat
(Rattus norvegicus)
Mammalia Tlr7 33
  • 83.25 (n)
mouse
(Mus musculus)
Mammalia Tlr7 33 16 34
  • 83.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TLR7 34
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TLR7 33 34
  • 67.25 (n)
lizard
(Anolis carolinensis)
Reptilia TLR7 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tlr7 33
  • 63.44 (n)
zebrafish
(Danio rerio)
Actinopterygii tlr7 33 34
  • 58.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7896 35
  • 26 (a)
Species where no ortholog for TLR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR7 Gene

ENSEMBL:
Gene Tree for TLR7 (if available)
TreeFam:
Gene Tree for TLR7 (if available)

Paralogs for TLR7 Gene

Paralogs for TLR7 Gene

(2) SIMAP similar genes for TLR7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TLR7: view

Variants for TLR7 Gene

Sequence variations from dbSNP and Humsavar for TLR7 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000192123 -- 12,883,265(+) T/C intron_variant
rs1000196064 -- 12,865,146(+) C/T upstream_transcript_variant
rs1000244111 -- 12,882,712(+) C/T intron_variant
rs1000292689 -- 12,872,154(+) G/A intron_variant
rs1001405175 -- 12,884,040(+) T/C intron_variant

Variation tolerance for TLR7 Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLR7 Gene

Human Gene Mutation Database (HGMD)
TLR7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TLR7 Gene

Disorders for TLR7 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TLR7 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
superficial basal cell carcinoma
  • multicentric basal cell carcinoma
anogenital venereal wart
  • anogenital human papilloma virus infectious disease
viral infectious disease
  • viral disease
septicemic plague
  • plague, septicemic
influenza
  • flu
- elite association - COSMIC cancer census association via MalaCards
Search TLR7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLR7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TLR7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR7 Gene

Publications for TLR7 Gene

  1. A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. (PMID: 19114863) Oh DY … Schumann RR (AIDS (London, England) 2009) 3 22 44 58
  2. Toll-like receptor polymorphisms and age-related macular degeneration. (PMID: 18385087) Edwards AO … Tosakulwong N (Investigative ophthalmology & visual science 2008) 3 22 44 58
  3. Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. (PMID: 18088248) Schott E … Berg T (Journal of viral hepatitis 2008) 3 22 44 58
  4. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. (PMID: 11022119) Du X … Beutler B (European cytokine network 2000) 2 3 4 58
  5. Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes. (PMID: 21061265) Monroy CM … El-Zein RA (Molecular carcinogenesis 2011) 3 44 58

Products for TLR7 Gene

  • Addgene plasmids for TLR7

Sources for TLR7 Gene

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