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Aliases for CLEC1A Gene

Aliases for CLEC1A Gene

  • C-Type Lectin Domain Family 1 Member A 2 3 3 5
  • CLEC-1 3 4
  • CLEC1 3 4
  • C-Type Lectin Domain Family 1, Member A 2
  • C-Type Lectin-Like Receptor-1 3
  • C-Type Lectin-Like Receptor 1 4

External Ids for CLEC1A Gene

Previous GeneCards Identifiers for CLEC1A Gene

  • GC12M010115
  • GC12M010222
  • GC12M009965
  • GC12M010271
  • GC12M010610
  • GC12M010769
  • GC12M011007
  • GC12M011297
  • GC12M011531
  • GC12M011724
  • GC12M011911

Summaries for CLEC1A Gene

Entrez Gene Summary for CLEC1A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CLEC1A Gene

CLEC1A (C-Type Lectin Domain Family 1 Member A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC12B.

Gene Wiki entry for CLEC1A Gene

Additional gene information for CLEC1A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC1A Gene

Genomics for CLEC1A Gene

GeneHancer (GH) Regulatory Elements for CLEC1A Gene

Promoters and enhancers for CLEC1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J010096 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 658.7 +13.4 13362 3 PRDM6 TAF1 POLR2A EZH2 CLEC1A CLEC7A GC12P010105 RN7SKP161
GH12J010030 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 6.8 +80.1 80058 2.7 STAT1 JUN MAFG BACH1 CBFA2T3 POLR2A GABPB1 NFE2 EMSY CLEC9A LOC102724020 CLEC7A CLEC12B TMEM52B OLR1 CLEC1A STYK1 LOC100421202
GH12J010089 Enhancer 0.6 Ensembl 7.8 +21.6 21626 0.8 NR2F1 ZNF10 BACH1 JUNB ATF2 RELA ZFHX2 IKZF1 EED ATF7 CLEC7A CLEC1A RN7SKP161 GC12P010105
GH12J010100 Enhancer 0.7 Ensembl ENCODE 5.1 +9.9 9854 2.4 SP1 ZFHX2 RFX1 RXRA EGR1 FEZF1 RFX5 GC12P010105 CLEC7A LINC02470 CLEC1A MAGOHB RN7SKP161
GH12J010094 Enhancer 0.3 Ensembl 8.6 +16.6 16626 0.4 IKZF1 CLEC1A GC12P010105 RN7SKP161
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLEC1A gene promoter:
  • SRF (504 AA)
  • SRF
  • MEF-2A
  • MEF-2
  • aMEF-2
  • CUTL1
  • HSF2
  • Pax-5
  • USF-1
  • USF-1:USF-2

Genomic Locations for CLEC1A Gene

Genomic Locations for CLEC1A Gene
42,124 bases
Minus strand
42,074 bases
Minus strand

Genomic View for CLEC1A Gene

Genes around CLEC1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC1A Gene

Proteins for CLEC1A Gene

  • Protein details for CLEC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-type lectin domain family 1 member A
    Protein Accession:
    Secondary Accessions:
    • Q8IUW7
    • Q9NZH3

    Protein attributes for CLEC1A Gene

    280 amino acids
    Molecular mass:
    31952 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLEC1A Gene

Post-translational modifications for CLEC1A Gene

  • Glycosylation at posLast=169169 and posLast=9595
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLEC1A Gene

Domains & Families for CLEC1A Gene

Gene Families for CLEC1A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CLEC1A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLEC1A: view

No data available for UniProtKB/Swiss-Prot for CLEC1A Gene

Function for CLEC1A Gene

Gene Ontology (GO) - Molecular Function for CLEC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10671229
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC1A: view
genes like me logo Genes that share phenotypes with CLEC1A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC1A

CRISPR Products

miRNA for CLEC1A Gene

miRTarBase miRNAs that target CLEC1A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC1A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLEC1A Gene

Localization for CLEC1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC1A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC1A gene
Compartment Confidence
plasma membrane 4
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CLEC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 10671229
GO:0005887 integral component of plasma membrane TAS 10671229
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC1A Gene

Pathways & Interactions for CLEC1A Gene

SuperPathways for CLEC1A Gene

No Data Available

Interacting Proteins for CLEC1A Gene

Gene Ontology (GO) - Biological Process for CLEC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 10671229
GO:0007166 cell surface receptor signaling pathway TAS 10671229
genes like me logo Genes that share ontologies with CLEC1A: view

No data available for Pathways by source and SIGNOR curated interactions for CLEC1A Gene

Drugs & Compounds for CLEC1A Gene

No Compound Related Data Available

Transcripts for CLEC1A Gene

Unigene Clusters for CLEC1A Gene

C-type lectin domain family 1, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC1A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: -
SP3: -
SP4: - - -
SP5: - - - -

Relevant External Links for CLEC1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLEC1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC1A Gene

This gene is overexpressed in Lung (x4.0).

Protein differential expression in normal tissues from HIPED for CLEC1A Gene

This gene is overexpressed in Cerebral cortex (46.7) and Placenta (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC1A Gene

Protein tissue co-expression partners for CLEC1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLEC1A Gene:


SOURCE GeneReport for Unigene cluster for CLEC1A Gene:


mRNA Expression by UniProt/SwissProt for CLEC1A Gene:

Tissue specificity: Expressed preferentially in dendritic cells.

Evidence on tissue expression from TISSUES for CLEC1A Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CLEC1A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC1A Gene

Orthologs for CLEC1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLEC1A 34 33
  • 99.64 (n)
(Canis familiaris)
Mammalia CLEC1A 33
  • 83.33 (n)
(Bos Taurus)
Mammalia CLEC1A 34 33
  • 81.13 (n)
(Mus musculus)
Mammalia Clec1a 16 34 33
  • 76.95 (n)
(Rattus norvegicus)
Mammalia Clec1a 33
  • 76.95 (n)
(Monodelphis domestica)
Mammalia CLEC1A 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 39 (a)
Species where no ortholog for CLEC1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC1A Gene

Gene Tree for CLEC1A (if available)
Gene Tree for CLEC1A (if available)
Evolutionary constrained regions (ECRs) for CLEC1A: view image

Paralogs for CLEC1A Gene

Paralogs for CLEC1A Gene

(8) SIMAP similar genes for CLEC1A Gene using alignment to 6 proteins:

  • F5H038_HUMAN
  • F8WCT4_HUMAN Pseudogenes for CLEC1A Gene

genes like me logo Genes that share paralogs with CLEC1A: view

Variants for CLEC1A Gene

Sequence variations from dbSNP and Humsavar for CLEC1A Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000153633 -- 10,083,878(-) A/G intron_variant
rs1000204271 -- 10,086,538(-) G/A intron_variant
rs1000219364 -- 10,087,966(-) C/G intron_variant
rs1000306099 -- 10,077,481(-) G/A intron_variant
rs1000358787 -- 10,077,289(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC1A Gene

Variant ID Type Subtype PubMed ID
esv1181821 CNV insertion 17803354
esv2275947 CNV deletion 18987734
esv2431271 CNV insertion 19546169
esv2745532 CNV deletion 23290073
esv3548742 CNV deletion 23714750
esv3628524 CNV loss 21293372
esv3628525 CNV loss 21293372
nsv826239 CNV loss 20364138

Variation tolerance for CLEC1A Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC1A Gene

Disorders for CLEC1A Gene

Additional Disease Information for CLEC1A

No disorders were found for CLEC1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC1A Gene

Publications for CLEC1A Gene

  1. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. (PMID: 10671229) Colonna M … Angman L (European journal of immunology 2000) 2 3 4 22 58
  2. A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PMID: 11745369) Sobanov Y … Hofer E (European journal of immunology 2001) 2 3 22 58
  3. Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells. (PMID: 17046204) Kanazawa N (Journal of dermatological science 2007) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CLEC1A Gene

Sources for CLEC1A Gene

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