Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL37 Gene

Aliases for MRPL37 Gene

  • Mitochondrial Ribosomal Protein L37 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein ML37 3 4
  • 39S Ribosomal Protein L2, Mitochondrial 3 4
  • MRP-L37 3 4
  • MRP-L2 3 4
  • L37mt 3 4
  • MRPL2 3 4
  • RPML2 3 4
  • L2mt 3 4
  • 39S Ribosomal Protein L37, Mitochondrial 3
  • Ribosomal Protein, Mitochondrial, L2 3

External Ids for MRPL37 Gene

Previous GeneCards Identifiers for MRPL37 Gene

  • GC01P054495
  • GC01P053554
  • GC01P054023
  • GC01P054035
  • GC01P054378
  • GC01P054649
  • GC01P052781

Summaries for MRPL37 Gene

Entrez Gene Summary for MRPL37 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL37 Gene

MRPL37 (Mitochondrial Ribosomal Protein L37) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL37 Gene

Additional gene information for MRPL37 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL37 Gene

Genomics for MRPL37 Gene

GeneHancer (GH) Regulatory Elements for MRPL37 Gene

Promoters and enhancers for MRPL37 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J054198 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.4 +16.2 16226 2.9 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B CYB5RL ENSG00000256407 MRPL37 MAGOH NDC1 LRRC42 PIR51493
GH01J054228 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +45.4 45408 1.6 STAT1 CBFA2T3 MITF ZFHX2 CTBP1 VEZF1 RBM22 ZFP36 ZNF600 FOS MRPL37 GC01P054226 SSBP3-AS1 SSBP3
GH01J054218 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.1 +36.1 36094 3.1 KLF1 MAX ZIC2 ZFHX2 POLR2B ZNF316 POLR2A EGR1 SCRT2 MAFK PIR40840 MRPL37 CDCP2 SSBP3-AS1 PIR51493
GH01J054227 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.8 +43.6 43605 1.3 CTCF KLF1 INSM2 KLF17 ZIC2 HIC1 GLIS2 POLR2A ZBTB48 PATZ1 GC01P054226 MRPL37 SSBP3-AS1 SSBP3
GH01J054248 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +65.8 65787 2.9 SCRT1 TFE3 SAP130 CEBPB ZEB1 TEAD3 JUND POLR2A SCRT2 RCOR1 SSBP3 MRPL37 GC01P054263 SSBP3-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRPL37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL37 gene promoter:
  • FOXO1a
  • FOXO1
  • POU2F1a
  • POU2F1
  • RP58
  • AML1a
  • RORalpha2
  • En-1
  • Pax-5

Genomic Locations for MRPL37 Gene

Genomic Locations for MRPL37 Gene
chr1:54,184,041-54,226,682
(GRCh38/hg38)
Size:
42,642 bases
Orientation:
Plus strand
chr1:54,649,714-54,691,137
(GRCh37/hg19)
Size:
41,424 bases
Orientation:
Plus strand

Genomic View for MRPL37 Gene

Genes around MRPL37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL37 Gene

Proteins for MRPL37 Gene

  • Protein details for MRPL37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZE1-RM37_HUMAN
    Recommended name:
    39S ribosomal protein L37, mitochondrial
    Protein Accession:
    Q9BZE1
    Secondary Accessions:
    • Q96Q67
    • Q9BWR1
    • Q9P0P3

    Protein attributes for MRPL37 Gene

    Size:
    423 amino acids
    Molecular mass:
    48117 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL37 forms a heterodimer with mL65.
    SequenceCaution:
    • Sequence=AAF36155.1; Type=Frameshift; Positions=9, 13, 25, 30, 326; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL37 Gene

neXtProt entry for MRPL37 Gene

Post-translational modifications for MRPL37 Gene

  • Ubiquitination at Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL37 Gene

No data available for DME Specific Peptides for MRPL37 Gene

Domains & Families for MRPL37 Gene

Gene Families for MRPL37 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL37 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BZE1

UniProtKB/Swiss-Prot:

RM37_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL37 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL37 family.
genes like me logo Genes that share domains with MRPL37: view

Function for MRPL37 Gene

Phenotypes From GWAS Catalog for MRPL37 Gene

Gene Ontology (GO) - Molecular Function for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IEA,NAS 11543634
genes like me logo Genes that share ontologies with MRPL37: view
genes like me logo Genes that share phenotypes with MRPL37: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL37 Gene

Localization for MRPL37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL37 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL37 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL37: view

Pathways & Interactions for MRPL37 Gene

genes like me logo Genes that share pathways with MRPL37: view

Gene Ontology (GO) - Biological Process for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL37: view

No data available for SIGNOR curated interactions for MRPL37 Gene

Drugs & Compounds for MRPL37 Gene

No Compound Related Data Available

Transcripts for MRPL37 Gene

mRNA/cDNA for MRPL37 Gene

Unigene Clusters for MRPL37 Gene

Mitochondrial ribosomal protein L37:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL37 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for MRPL37 Gene

GeneLoc Exon Structure for
MRPL37
ECgene alternative splicing isoforms for
MRPL37

Expression for MRPL37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL37 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9), Breast (6.3), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL37 Gene



Protein tissue co-expression partners for MRPL37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL37 Gene:

MRPL37

SOURCE GeneReport for Unigene cluster for MRPL37 Gene:

Hs.584908

Evidence on tissue expression from TISSUES for MRPL37 Gene

  • Muscle(4.5)
  • Blood(4.3)
  • Nervous system(4.1)
  • Lung(2.8)
  • Skin(2.4)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with MRPL37: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL37 Gene

Orthologs for MRPL37 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL37 34 33
  • 99.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL37 34 33
  • 85.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL37 34 33
  • 85.26 (n)
OneToMany
-- 34
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mrpl37 33
  • 82.35 (n)
mouse
(Mus musculus)
Mammalia Mrpl37 16 34 33
  • 82.27 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL37 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL37 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL37 34 33
  • 64.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL37 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl37 33
  • 59.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25339 33
zebrafish
(Danio rerio)
Actinopterygii mrpl37 34 33
  • 59.25 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL37 34 33
  • 45.14 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002400 33
  • 41.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8616 34
  • 25 (a)
OneToOne
Species where no ortholog for MRPL37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL37 Gene

ENSEMBL:
Gene Tree for MRPL37 (if available)
TreeFam:
Gene Tree for MRPL37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRPL37: view image

Paralogs for MRPL37 Gene

Pseudogenes.org Pseudogenes for MRPL37 Gene

genes like me logo Genes that share paralogs with MRPL37: view

No data available for Paralogs for MRPL37 Gene

Variants for MRPL37 Gene

Sequence variations from dbSNP and Humsavar for MRPL37 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000084632 -- 54,202,070(+) G/A intron_variant
rs1000229995 -- 54,221,365(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000242823 -- 54,215,870(+) C/T intron_variant
rs1000452424 -- 54,220,106(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000464287 -- 54,223,751(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL37 Gene

Variant ID Type Subtype PubMed ID
nsv477486 CNV novel sequence insertion 20440878

Variation tolerance for MRPL37 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.69; 95.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL37 Gene

Disorders for MRPL37 Gene

Additional Disease Information for MRPL37

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL37 Gene

Publications for MRPL37 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. [The structure and specific features of the cDNA expression of the human gene MRPL37]. (PMID: 15562971) Levshenkova EV … Frolova EI (Bioorganicheskaia khimiia 2004) 3 22 58

Products for MRPL37 Gene

Sources for MRPL37 Gene

Content
Loading form....