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Aliases for ZNF219 Gene

Aliases for ZNF219 Gene

  • Zinc Finger Protein 219 2 3 5
  • ZFP219 3

External Ids for ZNF219 Gene

Previous GeneCards Identifiers for ZNF219 Gene

  • GC14M018930
  • GC14M015345
  • GC14M019548
  • GC14M020628
  • GC14M021558
  • GC14M001678

Summaries for ZNF219 Gene

Entrez Gene Summary for ZNF219 Gene

  • This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]

GeneCards Summary for ZNF219 Gene

ZNF219 (Zinc Finger Protein 219) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZNF536.

UniProtKB/Swiss-Prot for ZNF219 Gene

  • Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5-GGGGG-3 (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity).

Gene Wiki entry for ZNF219 Gene

Additional gene information for ZNF219 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF219 Gene

Genomics for ZNF219 Gene

GeneHancer (GH) Regulatory Elements for ZNF219 Gene

Promoters and enhancers for ZNF219 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021092 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +3.3 3296 18.3 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF219 TMEM253 METTL3 METTL17 SUPT16H CHD8 TEP1 APEX1 PNP ARHGEF40
GH14I020453 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.8 +649.2 649179 3.9 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 SP3 NFYC OSGEP APEX1 SUPT16H METTL17 ENSG00000258515 TEP1 TTC5 PIP4P1 ZNF219 PNP
GH14I021068 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.1 +33.7 33677 5 HDGF ARID4B SIN3A DMAP1 ZBTB7B ZNF213 E2F8 ZNF143 FOS PAF1 ARHGEF40 NDRG2 TMEM253 ZNF219 RNASE7 TPPP2 RNASE13 ENSG00000255472 RNASE6 TOX4
GH14I020459 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 +643.3 643258 3.8 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 PIP4P1 SUPT16H METTL17 TEP1 CHD8 ENSG00000258515 RNA5SP382 APEX1 ZNF219
GH14I020997 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 10.6 +106.0 106037 2.9 KLF17 ZIC2 POLR2A SCRT2 PRDM10 ZNF600 FOS KLF8 SCRT1 SMARCC1 SLC39A2 LOC101929718 TPPP2 ENSG00000255472 RNASE13 ZNF219 TMEM253 RNASE7 METTL17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF219 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF219 gene promoter:

Genomic Locations for ZNF219 Gene

Genomic Locations for ZNF219 Gene
chr14:21,090,046-21,104,722
(GRCh38/hg38)
Size:
14,677 bases
Orientation:
Minus strand
chr14:21,558,205-21,572,881
(GRCh37/hg19)

Genomic View for ZNF219 Gene

Genes around ZNF219 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF219 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF219 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF219 Gene

Proteins for ZNF219 Gene

  • Protein details for ZNF219 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2Y4-ZN219_HUMAN
    Recommended name:
    Zinc finger protein 219
    Protein Accession:
    Q9P2Y4
    Secondary Accessions:
    • D3DS16
    • Q53Y57
    • Q8IYC1
    • Q9BW28

    Protein attributes for ZNF219 Gene

    Size:
    722 amino acids
    Molecular mass:
    76877 Da
    Quaternary structure:
    • Interacts with SOX9 (via C-terminus).

neXtProt entry for ZNF219 Gene

Post-translational modifications for ZNF219 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF219 Gene

Domains & Families for ZNF219 Gene

Gene Families for ZNF219 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF219 Gene

Suggested Antigen Peptide Sequences for ZNF219 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2Y4

UniProtKB/Swiss-Prot:

ZN219_HUMAN :
  • C2H2-type zinc-finger domains 5 and 6 are important for the interaction with SOX9.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • C2H2-type zinc-finger domains 5 and 6 are important for the interaction with SOX9.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF219: view

Function for ZNF219 Gene

Molecular function for ZNF219 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5-GGGGG-3 (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity).

Phenotypes From GWAS Catalog for ZNF219 Gene

Gene Ontology (GO) - Molecular Function for ZNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 14621294
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 14621294
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,IDA 14621294
GO:0003700 DNA binding transcription factor activity IDA,TAS 14621294
genes like me logo Genes that share ontologies with ZNF219: view
genes like me logo Genes that share phenotypes with ZNF219: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF219 Gene

Localization for ZNF219 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF219 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF219 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 10819330
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF219: view

Pathways & Interactions for ZNF219 Gene

SuperPathways for ZNF219 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with ZNF219: view

Pathways by source for ZNF219 Gene

1 BioSystems pathway for ZNF219 Gene

Gene Ontology (GO) - Biological Process for ZNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 14621294
GO:0001505 regulation of neurotransmitter levels IEA --
GO:0006351 transcription, DNA-templated TAS,IDA 14621294
GO:0006355 regulation of transcription, DNA-templated IMP 19549071
GO:0007165 signal transduction IBA --
genes like me logo Genes that share ontologies with ZNF219: view

No data available for SIGNOR curated interactions for ZNF219 Gene

Drugs & Compounds for ZNF219 Gene

(1) Drugs for ZNF219 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Histamine Approved, Investigational Pharma Full agonist, Agonist 1105
genes like me logo Genes that share compounds with ZNF219: view

Transcripts for ZNF219 Gene

Unigene Clusters for ZNF219 Gene

Zinc finger protein 219:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF219 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: - - - -
SP9: - -

Relevant External Links for ZNF219 Gene

GeneLoc Exon Structure for
ZNF219
ECgene alternative splicing isoforms for
ZNF219

Expression for ZNF219 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF219 Gene

Protein differential expression in normal tissues from HIPED for ZNF219 Gene

This gene is overexpressed in Gallbladder (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF219 Gene



Protein tissue co-expression partners for ZNF219 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF219 Gene:

ZNF219

SOURCE GeneReport for Unigene cluster for ZNF219 Gene:

Hs.250493

mRNA Expression by UniProt/SwissProt for ZNF219 Gene:

Q9P2Y4-ZN219_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF219 Gene

  • Nervous system(4.5)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with ZNF219: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF219 Gene

Orthologs for ZNF219 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF219 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF219 33 34
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia ZNF219 33 34
  • 89.48 (n)
dog
(Canis familiaris)
Mammalia ZNF219 33 34
  • 84.91 (n)
rat
(Rattus norvegicus)
Mammalia Zfp219 33
  • 83.36 (n)
mouse
(Mus musculus)
Mammalia Zfp219 33 16 34
  • 82.89 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF219 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF219 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF219 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495520 33
  • 52.47 (n)
zebrafish
(Danio rerio)
Actinopterygii ZNF219 34
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 34
  • 19 (a)
OneToMany
Species where no ortholog for ZNF219 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF219 Gene

ENSEMBL:
Gene Tree for ZNF219 (if available)
TreeFam:
Gene Tree for ZNF219 (if available)

Paralogs for ZNF219 Gene

Paralogs for ZNF219 Gene

genes like me logo Genes that share paralogs with ZNF219: view

Variants for ZNF219 Gene

Sequence variations from dbSNP and Humsavar for ZNF219 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs386352384 uncertain-significance, not provided 21,093,237(-) G/A coding_sequence_variant, synonymous_variant
rs1000157852 -- 21,099,224(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000195848 -- 21,101,178(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000510519 -- 21,098,894(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000534266 -- 21,096,153(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF219 Gene

Variant ID Type Subtype PubMed ID
nsv826882 CNV gain 20364138
dgv123n21 CNV loss 19592680

Variation tolerance for ZNF219 Gene

Gene Damage Index Score: 9.78; 89.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF219 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF219

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF219 Gene

Disorders for ZNF219 Gene

Additional Disease Information for ZNF219

No disorders were found for ZNF219 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF219 Gene

Publications for ZNF219 Gene

  1. Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219. (PMID: 19549071) Clough RL … Stefanis L (Journal of neurochemistry 2009) 3 4 22 58
  2. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. (PMID: 14621294) Sakai T … Maeda H (DNA research : an international journal for rapid publication of reports on genes and genomes 2003) 3 4 22 58
  3. Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region. (PMID: 10819330) Sakai T … Maeda H (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF219 Gene

Sources for ZNF219 Gene

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