External Ids for ZNF219 Gene
Previous GeneCards Identifiers for ZNF219 Gene
This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]
GeneCards Summary for ZNF219 Gene
ZNF219 (Zinc Finger Protein 219) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZNF536.
UniProtKB/Swiss-Prot for ZNF219 Gene
Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5-GGGGG-3 (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity).