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Aliases for TUBD1 Gene

Aliases for TUBD1 Gene

  • Tubulin Delta 1 2 3 5
  • Delta-Tubulin 3 4
  • TUBD 3 4
  • Tubulin Delta Chain 3
  • Tubulin, Delta 1 2

External Ids for TUBD1 Gene

Previous GeneCards Identifiers for TUBD1 Gene

  • GC17M057786
  • GC17M060386
  • GC17M058278
  • GC17M058412
  • GC17M055291
  • GC17M057936
  • GC17M053309

Summaries for TUBD1 Gene

GeneCards Summary for TUBD1 Gene

TUBD1 (Tubulin Delta 1) is a Protein Coding gene. Among its related pathways are PAK Pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBE1.

UniProtKB/Swiss-Prot for TUBD1 Gene

  • In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Tocris Summary for TUBD1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Additional gene information for TUBD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBD1 Gene

Genomics for TUBD1 Gene

GeneHancer (GH) Regulatory Elements for TUBD1 Gene

Promoters and enhancers for TUBD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I059891 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.3 -304 3.3 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 GC17P059894 RPS6KB1 TUBD1 SMG8 APPBP2 HEATR6 PPM1D LOC100996660 SKA2
GH17I059824 Promoter/Enhancer 2.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 57 +50.1 50059 36.2 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GC17P059842 GC17P059845 GC17M059841 GC17M059842 GC17M059843 MIR21 GC17P059844 GC17P059843 PPM1D TUBD1
GH17I059564 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 69.1 +327.0 327006 2.1 CLOCK YBX1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 DHX40 HEATR6 APPBP2 TUBD1 NDUFB8P2 RPS6KB1 LOC100996660 SKA2 SMG8 TRIM37
GH17I059151 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 46.3 +736.7 736655 9.6 CLOCK ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC GC17M059154 PRR11 SKA2 MKS1 NDUFB8P2 TUBD1 TRIM37 RPS6KB1 SMG8 RNFT1
GH17I059209 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 46.3 +682.7 682657 2.2 MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SMG8 TUBD1 RPS6KB1 MKS1 HEATR6 TRIM37 RNFT1 NDUFB8P2 SKA2 DHX40
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TUBD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUBD1 gene promoter:

Genomic Locations for TUBD1 Gene

Genomic Locations for TUBD1 Gene
chr17:59,859,479-59,892,945
(GRCh38/hg38)
Size:
33,467 bases
Orientation:
Minus strand
chr17:57,936,840-57,970,306
(GRCh37/hg19)

Genomic View for TUBD1 Gene

Genes around TUBD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBD1 Gene

Proteins for TUBD1 Gene

  • Protein details for TUBD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJT1-TBD_HUMAN
    Recommended name:
    Tubulin delta chain
    Protein Accession:
    Q9UJT1
    Secondary Accessions:
    • B4DPT8
    • B4DW01
    • D3DU02
    • E9PCA7
    • E9PCQ8
    • Q5KU36
    • Q9BWG9
    • Q9H7Z8

    Protein attributes for TUBD1 Gene

    Size:
    453 amino acids
    Molecular mass:
    51034 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TUBD1 Gene

neXtProt entry for TUBD1 Gene

Post-translational modifications for TUBD1 Gene

  • Ubiquitination at isoforms=2, 3, 5, 647 and posLast=7979

No data available for DME Specific Peptides for TUBD1 Gene

Domains & Families for TUBD1 Gene

Gene Families for TUBD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TUBD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJT1

UniProtKB/Swiss-Prot:

TBD_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBD1: view

Function for TUBD1 Gene

Molecular function for TUBD1 Gene

UniProtKB/Swiss-Prot Function:
In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Phenotypes From GWAS Catalog for TUBD1 Gene

Gene Ontology (GO) - Molecular Function for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBD1: view
genes like me logo Genes that share phenotypes with TUBD1: view

Animal Model Products

miRNA for TUBD1 Gene

miRTarBase miRNAs that target TUBD1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBD1 Gene

Localization for TUBD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm. Nucleus. Note=Associated with centrioles. Both cytoplasmic and nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBD1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005814 centriole TAS,IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TUBD1: view

Pathways & Interactions for TUBD1 Gene

genes like me logo Genes that share pathways with TUBD1: view

SIGNOR curated interactions for TUBD1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007017 microtubule-based process IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TUBD1: view

Drugs & Compounds for TUBD1 Gene

(4) Drugs for TUBD1 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vinblastine Approved Pharma Target, adduct 439
Vinblastine sulfate Pharma Anti-mitotic agent, Disrupts microtubules 0

(2) Additional Compounds for TUBD1 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for TUBD1 Gene

Compound Action Cas Number
MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor 917369-31-4
Nocodazole Microtubule inhibitor 31430-18-9
Noscapine hydrochloride Tubulin inhibitor; induces apoptosis 912-60-7
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBD1: view

Transcripts for TUBD1 Gene

Unigene Clusters for TUBD1 Gene

Tubulin, delta 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - -
SP10: - - - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - - -

Relevant External Links for TUBD1 Gene

GeneLoc Exon Structure for
TUBD1
ECgene alternative splicing isoforms for
TUBD1

Expression for TUBD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBD1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TUBD1 Gene:

TUBD1

SOURCE GeneReport for Unigene cluster for TUBD1 Gene:

Hs.463638

Evidence on tissue expression from TISSUES for TUBD1 Gene

  • Eye(4.1)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with TUBD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBD1 Gene

Orthologs for TUBD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TUBD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBD1 33 34
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia TUBD1 33 34
  • 91.02 (n)
cow
(Bos Taurus)
Mammalia TUBD1 33 34
  • 90.14 (n)
mouse
(Mus musculus)
Mammalia Tubd1 33 16 34
  • 84.33 (n)
rat
(Rattus norvegicus)
Mammalia Tubd1 33
  • 82.63 (n)
oppossum
(Monodelphis domestica)
Mammalia TUBD1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBD1 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TUBD1 33 34
  • 73.88 (n)
lizard
(Anolis carolinensis)
Reptilia TUBD1 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tubd1 33
  • 72.21 (n)
Str.12654 33
African clawed frog
(Xenopus laevis)
Amphibia tubd1-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii tubd1 33 34
  • 62.78 (n)
worm
(Caenorhabditis elegans)
Secernentea tbg-1 34
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 34
  • 21 (a)
OneToMany
Species where no ortholog for TUBD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBD1 Gene

ENSEMBL:
Gene Tree for TUBD1 (if available)
TreeFam:
Gene Tree for TUBD1 (if available)

Paralogs for TUBD1 Gene

Paralogs for TUBD1 Gene

(5) SIMAP similar genes for TUBD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TUBD1: view

Variants for TUBD1 Gene

Sequence variations from dbSNP and Humsavar for TUBD1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000021445 -- 59,891,985(-) A/T intron_variant
rs1000207163 -- 59,869,174(-) G/A/C intron_variant
rs1000312990 -- 59,862,850(-) G/A/C intron_variant
rs1000333130 -- 59,874,639(-) A/C/G coding_sequence_variant, intron_variant, synonymous_variant
rs1000336935 -- 59,893,558(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TUBD1 Gene

Variant ID Type Subtype PubMed ID
nsv1116228 CNV deletion 24896259
esv3640914 CNV gain 21293372
esv3554613 CNV deletion 23714750
esv2716085 CNV deletion 23290073

Variation tolerance for TUBD1 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.32; 95.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBD1 Gene

Human Gene Mutation Database (HGMD)
TUBD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBD1 Gene

Disorders for TUBD1 Gene

Additional Disease Information for TUBD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TUBD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBD1 Gene

Publications for TUBD1 Gene

  1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P … Stearns T (Nature cell biology 2000) 2 3 4 22 58
  2. Delta-tubulin is a component of intercellular bridges and both the early and mature perinuclear rings during spermatogenesis. (PMID: 15081367) Kato A … Todokoro K (Developmental biology 2004) 3 4 22 58
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TUBD1 Gene

Sources for TUBD1 Gene