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Aliases for ING4 Gene

Aliases for ING4 Gene

  • Inhibitor Of Growth Family Member 4 2 3 5
  • P29ING4 3 4
  • Candidate Tumor Suppressor P33 ING1 Homolog 3
  • Inhibitor Of Growth Protein 4 3
  • Brain My036 Protein 3
  • My036 3

External Ids for ING4 Gene

Previous GeneCards Identifiers for ING4 Gene

  • GC12P006629
  • GC12P006754
  • GC12M006639
  • GC12M006630
  • GC12M006629
  • GC12M006759

Summaries for ING4 Gene

Entrez Gene Summary for ING4 Gene

  • This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for ING4 Gene

ING4 (Inhibitor Of Growth Family Member 4) is a Protein Coding gene. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and methylated histone binding. An important paralog of this gene is ING5.

UniProtKB/Swiss-Prot for ING4 Gene

  • Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factors (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).

Gene Wiki entry for ING4 Gene

Additional gene information for ING4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ING4 Gene

Genomics for ING4 Gene

GeneHancer (GH) Regulatory Elements for ING4 Gene

Promoters and enhancers for ING4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J006662 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 665.9 -0.1 -78 2.2 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000219410 ING4 ACRBP ZNF384 CHD4 ENSG00000247853 ENSG00000126749 NCAPD2 SPSB2 SCARNA12
GH12J006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42.8 -290.5 -290509 25.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PTPN6 C12orf57 EMG1 ZNF384 ENSG00000219410 ENSG00000247853 SPSB2 SCARNA12 NCAPD2 ENSG00000256967
GH12J006866 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 46.3 -207.1 -207095 8.5 HDGF SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 SPSB2 LRRC23 TPI1 PIR60823 ING4 ZNF384 ATN1 ENSG00000219410 LOC100419928 NCAPD2
GH12J006331 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27 +325.0 325011 12.7 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 ZC3H11A TNFRSF1A ZNF384 ENSG00000219410 ENSG00000247853 CHD4 NOP2 SPSB2 ING4 SCARNA12 NCAPD2
GH12J006602 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.4 +57.4 57421 7.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CHD4 ZNF384 ENSG00000219410 ENSG00000247853 NOP2 NCAPD2 ING4 SPSB2 ENSG00000126749 SCARNA12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ING4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ING4 gene promoter:
  • Gfi-1
  • POU3F2
  • ATF
  • MAZR
  • Sp1
  • Pbx1a
  • ARP-1
  • MyoD
  • STAT5A

Genomic Locations for ING4 Gene

Genomic Locations for ING4 Gene
chr12:6,650,280-6,663,149
(GRCh38/hg38)
Size:
12,870 bases
Orientation:
Minus strand
chr12:6,759,446-6,772,314
(GRCh37/hg19)
Size:
12,869 bases
Orientation:
Minus strand

Genomic View for ING4 Gene

Genes around ING4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ING4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ING4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING4 Gene

Proteins for ING4 Gene

  • Protein details for ING4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNL4-ING4_HUMAN
    Recommended name:
    Inhibitor of growth protein 4
    Protein Accession:
    Q9UNL4
    Secondary Accessions:
    • A4KYM4
    • A4KYM6
    • D3DUR8
    • Q0EF62
    • Q0EF63
    • Q4VBQ6
    • Q96E15
    • Q9H3J0

    Protein attributes for ING4 Gene

    Size:
    249 amino acids
    Molecular mass:
    28530 Da
    Quaternary structure:
    • Homodimer. Interacts with H3K4me3 and to a lesser extent with H3K4me2, the interaction augments HBO1 acetylation activity on H3 tails. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with EP300, RELA and TP53; these interactions may be indirect. Interacts with EGLN1. Interacts with BCL2A1 (By similarity).
    SequenceCaution:
    • Sequence=AAG43153.1; Type=Frameshift; Positions=240, 243; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ING4 Gene

    Alternative splice isoforms for ING4 Gene

neXtProt entry for ING4 Gene

Post-translational modifications for ING4 Gene

  • Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases susceptibility to degradation.
  • Ubiquitination at Lys66
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ING4 Gene

Domains & Families for ING4 Gene

Gene Families for ING4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9UNL4

UniProtKB/Swiss-Prot:

ING4_HUMAN :
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • Belongs to the ING family.
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • The N-terminal coiled-coil domain mediates homodimerization.
Family:
  • Belongs to the ING family.
genes like me logo Genes that share domains with ING4: view

Function for ING4 Gene

Molecular function for ING4 Gene

UniProtKB/Swiss-Prot Function:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factors (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).

Phenotypes From GWAS Catalog for ING4 Gene

Gene Ontology (GO) - Molecular Function for ING4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 16387653
GO:0005515 protein binding IPI 12750254
GO:0035064 methylated histone binding IDA,IEA 16728974
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ING4: view
genes like me logo Genes that share phenotypes with ING4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ING4

Clone Products

  • Addgene plasmids for ING4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ING4 Gene

Localization for ING4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ING4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ING4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 16387653
GO:0005634 nucleus IDA,IEA 15029197
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with ING4: view

Pathways & Interactions for ING4 Gene

genes like me logo Genes that share pathways with ING4: view

Pathways by source for ING4 Gene

Gene Ontology (GO) - Biological Process for ING4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IDA 16387653
GO:0006325 chromatin organization IEA --
GO:0006473 protein acetylation IDA 12750254
GO:0006915 apoptotic process IDA,IEA 15251430
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA 16387653
genes like me logo Genes that share ontologies with ING4: view

No data available for SIGNOR curated interactions for ING4 Gene

Drugs & Compounds for ING4 Gene

No Compound Related Data Available

Transcripts for ING4 Gene

Unigene Clusters for ING4 Gene

Inhibitor of growth family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ING4

Clone Products

  • Addgene plasmids for ING4

Alternative Splicing Database (ASD) splice patterns (SP) for ING4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - -
SP9: - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - -
SP13: - -
SP14: - - - -
SP15: - -
SP16: - - -
SP17: - - - - -
SP18: - - -
SP19: - - - - - - - -
SP20:
SP21: - - -
SP22: -

ExUns: 11h
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for ING4 Gene

GeneLoc Exon Structure for
ING4
ECgene alternative splicing isoforms for
ING4

Expression for ING4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ING4 Gene

Protein differential expression in normal tissues from HIPED for ING4 Gene

This gene is overexpressed in Fetal testis (13.3), Fetal ovary (12.8), Blymphocyte (8.7), Fetal Brain (7.8), NK cells (7.7), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ING4 Gene



Protein tissue co-expression partners for ING4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ING4 Gene:

ING4

SOURCE GeneReport for Unigene cluster for ING4 Gene:

Hs.524210

Evidence on tissue expression from TISSUES for ING4 Gene

  • Nervous system(4.6)
  • Lung(4.4)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ING4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ING4 Gene

Orthologs for ING4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ING4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ING4 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
OneToMany
ING4 33
  • 95.93 (n)
-- 34
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ING4 34
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ing4 33
  • 96.05 (n)
cow
(Bos Taurus)
Mammalia ING4 34 33
  • 94.58 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ing4 16 34 33
  • 92.95 (n)
chicken
(Gallus gallus)
Aves ING4 34 33
  • 79.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ING4 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ing4 33
  • 76.19 (n)
zebrafish
(Danio rerio)
Actinopterygii ing4 34 33
  • 73.2 (n)
OneToOne
wufb11d09 33
fruit fly
(Drosophila melanogaster)
Insecta CG9293 34 35 33
  • 58.67 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009992 33
  • 58.4 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO23 34
  • 19 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.14443 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToMany
Species where no ortholog for ING4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for ING4 Gene

ENSEMBL:
Gene Tree for ING4 (if available)
TreeFam:
Gene Tree for ING4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ING4: view image

Paralogs for ING4 Gene

Paralogs for ING4 Gene

(4) SIMAP similar genes for ING4 Gene using alignment to 7 proteins:

  • ING4_HUMAN
  • A4KYM5_HUMAN
  • A4KYM7_HUMAN
  • E9PJ14_HUMAN
  • E9PNE3_HUMAN
  • H0YEH7_HUMAN
  • R4GNG1_HUMAN
genes like me logo Genes that share paralogs with ING4: view

Variants for ING4 Gene

Sequence variations from dbSNP and Humsavar for ING4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs193921122 uncertain-significance, Malignant tumor of prostate 6,653,001(-) G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000436566 -- 6,662,674(-) T/C intron_variant
rs1001254100 -- 6,653,194(-) T/C intron_variant
rs1001347935 -- 6,656,339(-) C/A intron_variant
rs1001419425 -- 6,663,267(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ING4 Gene

Variant ID Type Subtype PubMed ID
nsv509452 CNV insertion 20534489
nsv832322 CNV loss 17160897
nsv832323 CNV loss 17160897

Variation tolerance for ING4 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ING4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ING4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ING4 Gene

Disorders for ING4 Gene

Additional Disease Information for ING4

No disorders were found for ING4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ING4 Gene

Publications for ING4 Gene

  1. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PMID: 12750254) Shiseki M … Harris CC (Cancer research 2003) 2 3 4 22 58
  2. Nuclear localization signal of ING4 plays a key role in its binding to p53. (PMID: 15882981) Zhang X … Han ZG (Biochemical and biophysical research communications 2005) 3 4 22 58
  3. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. (PMID: 15029197) Garkavtsev I … Jain RK (Nature 2004) 3 4 22 58
  4. Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins. (PMID: 22334692) Culurgioni S … Blanco FJ (The Journal of biological chemistry 2012) 3 4 58
  5. Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53. (PMID: 21454715) Guo Q … Fast W (The Journal of biological chemistry 2011) 3 4 58

Products for ING4 Gene

Sources for ING4 Gene