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Aliases for ZNF593 Gene

Aliases for ZNF593 Gene

  • Zinc Finger Protein 593 2 3 3 5
  • Zinc Finger Protein T86 3 4
  • ZT86 3 4

External Ids for ZNF593 Gene

Previous GeneCards Identifiers for ZNF593 Gene

  • GC01P026093
  • GC01P026361
  • GC01P026496
  • GC01P024750

Summaries for ZNF593 Gene

GeneCards Summary for ZNF593 Gene

ZNF593 (Zinc Finger Protein 593) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity.

UniProtKB/Swiss-Prot for ZNF593 Gene

  • Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.

Gene Wiki entry for ZNF593 Gene

Additional gene information for ZNF593 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF593 Gene

Genomics for ZNF593 Gene

GeneHancer (GH) Regulatory Elements for ZNF593 Gene

Promoters and enhancers for ZNF593 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J026168 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.2 157 2.5 DMAP1 IRF4 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC GLIS1 NBN C1orf232 ENSG00000236782 ZNF593 CNKSR1 ARID1A HMGN2 LOC101928324 ENSG00000261349 GPN2 RSRP1
GH01J026233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.4 +64.7 64714 2.3 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 CEP85 ARID1A HMGN2 CD52 ZNF593 NPM1P39 UBXN11 ENSG00000261349 LOC101928324 LOC101928728
GH01J026618 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24 +450.5 450525 4 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 ARID1A HMGN2 ACTG1P20 GPN2 LOC101928324 GPATCH3 AHDC1 RPL17P9 NPM1P39 ZNF593
GH01J026691 Promoter/Enhancer 3.3 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.6 +527.2 527187 12.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ARID1A LOC101928728 HMGN2 ACTG1P20 LOC101928324 PIGV GPN2 GPATCH3 TMEM222 RPL17P9
GH01J025858 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.6 -309.3 -309302 4.6 CLOCK YBX1 YY1 ZNF213 ZNF416 ZNF143 SP3 MEF2D SSRP1 ZNF610 AUNIP ENSG00000236528 ARID1A HMGN2 MTFR1L ENSG00000261349 SELENON LOC101928324 RPL17P9 ENSG00000207302
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF593 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF593 gene promoter:
  • ATF-2
  • c-Jun
  • AP-1
  • Elk-1
  • HEN1
  • FAC1
  • AML1a
  • p53
  • c-Fos

Genomic Locations for ZNF593 Gene

Genomic Locations for ZNF593 Gene
chr1:26,169,871-26,170,873
(GRCh38/hg38)
Size:
1,003 bases
Orientation:
Plus strand
chr1:26,496,362-26,498,551
(GRCh37/hg19)
Size:
2,190 bases
Orientation:
Plus strand

Genomic View for ZNF593 Gene

Genes around ZNF593 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF593 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF593 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF593 Gene

Proteins for ZNF593 Gene

  • Protein details for ZNF593 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00488-ZN593_HUMAN
    Recommended name:
    Zinc finger protein 593
    Protein Accession:
    O00488
    Secondary Accessions:
    • B2R4S0
    • Q5T2H7

    Protein attributes for ZNF593 Gene

    Size:
    134 amino acids
    Molecular mass:
    15199 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH02580.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH19267.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA20369.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG34867.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF593 Gene

neXtProt entry for ZNF593 Gene

Post-translational modifications for ZNF593 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF593 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF593 Gene

Domains & Families for ZNF593 Gene

Gene Families for ZNF593 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF593 Gene

Suggested Antigen Peptide Sequences for ZNF593 Gene

Graphical View of Domain Structure for InterPro Entry

O00488

UniProtKB/Swiss-Prot:

ZN593_HUMAN :
  • The protein is largely disordered, with the exception of the zinc finger domain.
  • Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.
Domain:
  • The protein is largely disordered, with the exception of the zinc finger domain.
Family:
  • Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF593: view

Function for ZNF593 Gene

Molecular function for ZNF593 Gene

UniProtKB/Swiss-Prot Function:
Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.

Phenotypes From GWAS Catalog for ZNF593 Gene

Gene Ontology (GO) - Molecular Function for ZNF593 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000035 NOT acyl binding IBA --
GO:0000036 NOT acyl carrier activity IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF593: view
genes like me logo Genes that share phenotypes with ZNF593: view

Animal Model Products

CRISPR Products

miRNA for ZNF593 Gene

miRTarBase miRNAs that target ZNF593

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF593

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF593 Gene

Localization for ZNF593 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF593 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF593 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF593 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005829 NOT cytosol IBA --
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with ZNF593: view

Pathways & Interactions for ZNF593 Gene

SuperPathways for ZNF593 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF593 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009245 NOT lipid A biosynthetic process IBA --
GO:0045944 positive regulation of transcription by RNA polymerase II IGI 9115366
genes like me logo Genes that share ontologies with ZNF593: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF593 Gene

Drugs & Compounds for ZNF593 Gene

No Compound Related Data Available

Transcripts for ZNF593 Gene

mRNA/cDNA for ZNF593 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(150) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF593 Gene

Zinc finger protein 593:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF593

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF593 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for ZNF593 Gene

GeneLoc Exon Structure for
ZNF593
ECgene alternative splicing isoforms for
ZNF593

Expression for ZNF593 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF593 Gene

Protein differential expression in normal tissues from HIPED for ZNF593 Gene

This gene is overexpressed in Lung (57.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF593 Gene



Protein tissue co-expression partners for ZNF593 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF593 Gene:

ZNF593

SOURCE GeneReport for Unigene cluster for ZNF593 Gene:

Hs.477273

mRNA Expression by UniProt/SwissProt for ZNF593 Gene:

O00488-ZN593_HUMAN
Tissue specificity: Ubiquitous. Detected in spleen, prostate, testis, small intestine, colon and to a minor level in thymus and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ZNF593 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF593: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF593 Gene

Orthologs for ZNF593 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF593 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF593 34 33
  • 99.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF593 34 33
  • 88.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF593 34 33
  • 87.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp593 16 34 33
  • 86.07 (n)
rat
(Rattus norvegicus)
Mammalia Zfp593 33
  • 85.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF593 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF593 34 33
  • 67.45 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF593 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf593 33
  • 55.11 (n)
zebrafish
(Danio rerio)
Actinopterygii znf593 34 33
  • 56.35 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3224 34 33
  • 52.94 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003698 33
  • 51.35 (n)
worm
(Caenorhabditis elegans)
Secernentea Y56A3A.18 34 33
  • 51.18 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD20 36 34
  • 23 (a)
Species where no ortholog for ZNF593 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF593 Gene

ENSEMBL:
Gene Tree for ZNF593 (if available)
TreeFam:
Gene Tree for ZNF593 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF593: view image

Paralogs for ZNF593 Gene

No data available for Paralogs for ZNF593 Gene

Variants for ZNF593 Gene

Sequence variations from dbSNP and Humsavar for ZNF593 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000438754 -- 26,169,162(+) A/G upstream_transcript_variant
rs1001791870 -- 26,168,450(+) A/G upstream_transcript_variant
rs1003442049 -- 26,170,564(+) C/G coding_sequence_variant, intron_variant, missense_variant
rs1005264087 -- 26,169,280(+) G/A upstream_transcript_variant
rs1005788142 -- 26,169,589(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF593 Gene

Variant ID Type Subtype PubMed ID
nsv1002191 CNV gain 25217958

Variation tolerance for ZNF593 Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF593 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF593

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF593 Gene

Disorders for ZNF593 Gene

Additional Disease Information for ZNF593

No disorders were found for ZNF593 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF593 Gene

Publications for ZNF593 Gene

  1. A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2. (PMID: 9115366) Terunuma A … Noda T (Nucleic acids research 1997) 2 3 4 58
  2. The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein. (PMID: 18287285) Hayes PL … Peterson FC (Protein science : a publication of the Protein Society 2008) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF593 Gene

Sources for ZNF593 Gene

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