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Aliases for RRP15 Gene

Aliases for RRP15 Gene

  • Ribosomal RNA Processing 15 Homolog 2 3 5
  • KIAA0507 2 3 4
  • Ribosomal RNA-Processing Protein 15 3 4
  • Ribosomal RNA Processing 15 Homolog (S. Cerevisiae) 2
  • RRP15-Like Protein 3
  • CGI-115 3

External Ids for RRP15 Gene

Previous HGNC Symbols for RRP15 Gene

  • KIAA0507

Previous GeneCards Identifiers for RRP15 Gene

  • GC01P216526
  • GC01P218458
  • GC01P189126

Summaries for RRP15 Gene

Entrez Gene Summary for RRP15 Gene

  • This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for RRP15 Gene

RRP15 (Ribosomal RNA Processing 15 Homolog) is a Protein Coding gene.

Gene Wiki entry for RRP15 Gene

Additional gene information for RRP15 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP15 Gene

Genomics for RRP15 Gene

GeneHancer (GH) Regulatory Elements for RRP15 Gene

Promoters and enhancers for RRP15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J218284 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 704 +0.2 225 2.2 CLOCK ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZNF610 RRP15 RIMKLBP2 ENSG00000223842 GC01M218293
GH01J218344 Promoter/Enhancer 2.9 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.6 +64.2 64176 9.9 PKNOX1 CLOCK SIN3A FEZF1 ZNF2 SP3 REST ZNF592 SMARCA4 ZSCAN16 TGFB2 RRP15 TGFB2-AS1 GC01M218380
GH01J219173 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 12.6 +889.6 889641 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 LYPLAL1 LYPLAL1-DT RRP15 GC01M219200
GH01J218373 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +90.6 90568 4.6 FOXA2 SIN3A FEZF1 BRCA1 GLIS2 FOS RUNX3 KLF13 SP3 JUNB RRP15 TGFB2 TGFB2-AS1 C1orf143 GC01M218380
GH01J218369 Enhancer 1.1 Ensembl ENCODE dbSUPER 18.5 +85.9 85947 3.9 SOX13 FOXA2 CEBPG ZKSCAN1 NR2F6 MAFK GATAD2A SOX5 TEAD1 RXRA RRP15 TGFB2-AS1 TGFB2 C1orf143 GC01M218380
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RRP15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RRP15 gene promoter:
  • RFX1
  • Bach2
  • Pax-5
  • Evi-1
  • Max1
  • c-Myc
  • TGIF
  • Meis-1b
  • Meis-1a
  • Meis-1

Genomic Locations for RRP15 Gene

Genomic Locations for RRP15 Gene
chr1:218,285,285-218,337,983
(GRCh38/hg38)
Size:
52,699 bases
Orientation:
Plus strand
chr1:218,458,629-218,511,325
(GRCh37/hg19)
Size:
52,697 bases
Orientation:
Plus strand

Genomic View for RRP15 Gene

Genes around RRP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP15 Gene

Proteins for RRP15 Gene

  • Protein details for RRP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3B9-RRP15_HUMAN
    Recommended name:
    RRP15-like protein
    Protein Accession:
    Q9Y3B9

    Protein attributes for RRP15 Gene

    Size:
    282 amino acids
    Molecular mass:
    31484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34110.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH20641.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RRP15 Gene

Post-translational modifications for RRP15 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at posLast=208208, posLast=207207, and posLast=179179
  • Modification sites at PhosphoSitePlus

Other Protein References for RRP15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP15 Gene

Domains & Families for RRP15 Gene

Gene Families for RRP15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRP15 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RRP15 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3B9

UniProtKB/Swiss-Prot:

RRP15_HUMAN :
  • Belongs to the RRP15 family.
Family:
  • Belongs to the RRP15 family.
genes like me logo Genes that share domains with RRP15: view

Function for RRP15 Gene

Phenotypes From GWAS Catalog for RRP15 Gene

genes like me logo Genes that share phenotypes with RRP15: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP15 Gene

Localization for RRP15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRP15 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytoskeleton 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with RRP15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RRP15 Gene

Pathways & Interactions for RRP15 Gene

SuperPathways for RRP15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IBA --
GO:0000470 maturation of LSU-rRNA IBA --
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with RRP15: view

No data available for Pathways by source and SIGNOR curated interactions for RRP15 Gene

Drugs & Compounds for RRP15 Gene

No Compound Related Data Available

Transcripts for RRP15 Gene

mRNA/cDNA for RRP15 Gene

Unigene Clusters for RRP15 Gene

Ribosomal RNA processing 15 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP15 Gene

No ASD Table

Relevant External Links for RRP15 Gene

GeneLoc Exon Structure for
RRP15
ECgene alternative splicing isoforms for
RRP15

Expression for RRP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRP15 Gene

This gene is overexpressed in Lung (34.8) and Adrenal (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RRP15 Gene



Protein tissue co-expression partners for RRP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRP15 Gene:

RRP15

SOURCE GeneReport for Unigene cluster for RRP15 Gene:

Hs.660109

Evidence on tissue expression from TISSUES for RRP15 Gene

  • Skin(2)
genes like me logo Genes that share expression patterns with RRP15: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRP15 Gene

Orthologs for RRP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for RRP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRP15 34 33
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RRP15 34 33
  • 83.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RRP15 34 33
  • 82.51 (n)
OneToMany
-- 34
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rrp15 16 34 33
  • 77.45 (n)
rat
(Rattus norvegicus)
Mammalia Rrp15 33
  • 76.24 (n)
oppossum
(Monodelphis domestica)
Mammalia RRP15 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRP15 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRP15 34 33
  • 70.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRP15 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrp15 33
  • 66 (n)
Str.6662 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18622 33
zebrafish
(Danio rerio)
Actinopterygii rrp15 34 33
  • 63.78 (n)
OneToOne
wufa20e10 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13265 33
fruit fly
(Drosophila melanogaster)
Insecta CG3817 34
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToOne
Species where no ortholog for RRP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RRP15 Gene

ENSEMBL:
Gene Tree for RRP15 (if available)
TreeFam:
Gene Tree for RRP15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RRP15: view image

Paralogs for RRP15 Gene

No data available for Paralogs for RRP15 Gene

Variants for RRP15 Gene

Sequence variations from dbSNP and Humsavar for RRP15 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000084257 -- 218,334,567(+) A/G/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000119690 -- 218,314,450(+) G/A intron_variant
rs1000172028 -- 218,318,304(+) TTTTT/TTTT intron_variant
rs1000174107 -- 218,314,132(+) G/T intron_variant
rs1000212412 -- 218,294,503(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RRP15 Gene

Variant ID Type Subtype PubMed ID
esv3588869 CNV gain 21293372
nsv1005829 CNV gain 25217958
nsv4598 CNV deletion 18451855

Variation tolerance for RRP15 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRP15 Gene

Human Gene Mutation Database (HGMD)
RRP15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRP15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP15 Gene

Disorders for RRP15 Gene

Additional Disease Information for RRP15

No disorders were found for RRP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP15 Gene

Publications for RRP15 Gene

  1. Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation. (PMID: 15769876) De Marchis ML … Fatica A (RNA (New York, N.Y.) 2005) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4 58
  4. The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells. (PMID: 28099941) Dong Z … Jiang W (Oncotarget 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RRP15 Gene

Sources for RRP15 Gene

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