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Aliases for ATP5F1C Gene

Aliases for ATP5F1C Gene

  • ATP Synthase F1 Subunit Gamma 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Gamma Polypeptide 1 2 3 5
  • ATP5C1 3 4 5
  • F-ATPase Gamma Subunit 3 4
  • ATP5CL1 3 4
  • ATP5C 3 4
  • Mitochondrial ATP Synthase, Gamma Subunit 1 3
  • ATP Synthase Subunit Gamma, Mitochondrial 3
  • ATP Synthase Gamma Chain, Mitochondrial 3

External Ids for ATP5F1C Gene

Previous HGNC Symbols for ATP5F1C Gene

  • ATP5CL1
  • ATP5C
  • ATP5C1

Summaries for ATP5F1C Gene

Entrez Gene Summary for ATP5F1C Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5F1C Gene

ATP5F1C (ATP Synthase F1 Subunit Gamma) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism.

UniProtKB/Swiss-Prot for ATP5F1C Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene Wiki entry for ATP5F1C Gene

Additional gene information for ATP5F1C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5F1C Gene

Genomics for ATP5F1C Gene

GeneHancer (GH) Regulatory Elements for ATP5F1C Gene

Promoters and enhancers for ATP5F1C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I007786 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 565.6 +0.7 667 4.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ATP5F1C KIN ITIH2 GC10M007790
GH10I007817 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.1 +30.6 30587 2.3 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 TAF3 ATP5F1C ITIH2 GC10M007828
GH10I007665 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 -121.4 -121368 2.9 KLF1 ZNF449 ZFP64 BACH1 ZIC2 RAD21 ZNF7 ZNF335 ZNF121 ZFHX2 ITIH5 ATP5F1C GC10M007594
GH10I007872 Enhancer 0.9 Ensembl ENCODE 5.2 +84.3 84272 0.4 CTCF ZNF384 ZNF2 RAD21 ZNF335 ZNF366 ARID2 ZNF143 SMC3 ZNF362 TAF3 KIN ATP5F1C GC10P007866 GC10M007907
GH10I007909 Enhancer 0.8 ENCODE 5.5 +120.9 120904 0.2 ZFP64 ZNF48 ZSCAN9 RAD21 RARA ETS1 YY1 TCF12 ZNF366 THAP11 ATP5F1C GC10M007907 GC10P007866 TAF3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATP5F1C on UCSC Golden Path with GeneCards custom track

Genomic Locations for ATP5F1C Gene

Genomic Locations for ATP5F1C Gene
chr10:7,788,129-7,807,815
(GRCh38/hg38)
Size:
19,687 bases
Orientation:
Plus strand
chr10:7,830,092-7,849,778
(GRCh37/hg19)

Genomic View for ATP5F1C Gene

Genes around ATP5F1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5F1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5F1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5F1C Gene

Proteins for ATP5F1C Gene

  • Protein details for ATP5F1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36542-ATPG_HUMAN
    Recommended name:
    ATP synthase subunit gamma, mitochondrial
    Protein Accession:
    P36542
    Secondary Accessions:
    • A8KA31
    • Q5VYP3
    • Q6I9V2
    • Q96AS8

    Protein attributes for ATP5F1C Gene

    Size:
    298 amino acids
    Molecular mass:
    32996 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

    Alternative splice isoforms for ATP5F1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP5F1C Gene

Post-translational modifications for ATP5F1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5F1C Gene

No data available for DME Specific Peptides for ATP5F1C Gene

Domains & Families for ATP5F1C Gene

Gene Families for ATP5F1C Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ATP5F1C Gene

Graphical View of Domain Structure for InterPro Entry

P36542

UniProtKB/Swiss-Prot:

ATPG_HUMAN :
  • Belongs to the ATPase gamma chain family.
Family:
  • Belongs to the ATPase gamma chain family.
genes like me logo Genes that share domains with ATP5F1C: view

Function for ATP5F1C Gene

Molecular function for ATP5F1C Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene Ontology (GO) - Molecular Function for ATP5F1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0016887 contributes_to ATPase activity NAS 8227057
GO:0022857 transmembrane transporter activity IC 12110673
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism IEA --
genes like me logo Genes that share ontologies with ATP5F1C: view
genes like me logo Genes that share phenotypes with ATP5F1C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5F1C Gene

Localization for ATP5F1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5F1C Gene

Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5F1C gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 2
peroxisome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ATP5F1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) NAS 8227057
GO:0005739 mitochondrion NAS 8227057
GO:0005743 mitochondrial inner membrane ISS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ATP5F1C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATP5F1C Gene

Pathways & Interactions for ATP5F1C Gene

genes like me logo Genes that share pathways with ATP5F1C: view

Gene Ontology (GO) - Biological Process for ATP5F1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006119 oxidative phosphorylation NAS 8227057
GO:0006754 ATP biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IEA --
genes like me logo Genes that share ontologies with ATP5F1C: view

No data available for SIGNOR curated interactions for ATP5F1C Gene

Drugs & Compounds for ATP5F1C Gene

No Compound Related Data Available

Transcripts for ATP5F1C Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5F1C Gene

No ASD Table

Relevant External Links for ATP5F1C Gene

GeneLoc Exon Structure for
ATP5F1C
ECgene alternative splicing isoforms for
ATP5F1C

Expression for ATP5F1C Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP5F1C Gene:

ATP5F1C

mRNA Expression by UniProt/SwissProt for ATP5F1C Gene:

P36542-ATPG_HUMAN
Tissue specificity: Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta.

Evidence on tissue expression from TISSUES for ATP5F1C Gene

  • Muscle(4.7)
  • Heart(4.6)
  • Liver(4.6)
  • Nervous system(4.4)
  • Pancreas(3.4)
  • Lung(3.3)
  • Stomach(3.3)
  • Skin(3.1)
  • Blood(2.8)
  • Kidney(2.4)
  • Adrenal gland(2.2)
  • Eye(2.2)
  • Thyroid gland(2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5F1C Gene

Orthologs for ATP5F1C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP5F1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5C1 34 33
  • 99.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5C1 33
  • 90.49 (n)
-- 34
  • 87 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ATP5C1 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 90 (a)
OneToMany
-- 34
  • 87 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ATP5C1 33 34
  • 87.58 (n)
mouse
(Mus musculus)
Mammalia Atp5c1 33 16 34
  • 87.47 (n)
rat
(Rattus norvegicus)
Mammalia Atp5c1 33
  • 85.35 (n)
chicken
(Gallus gallus)
Aves ATP5C1 33 34
  • 78 (n)
lizard
(Anolis carolinensis)
Reptilia ATP5C1 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5c1 33
  • 75.11 (n)
Str.4048 33
zebrafish
(Danio rerio)
Actinopterygii atp5c1 33 34
  • 71 (n)
wufk34c05 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8471 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007966 33
  • 57.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-gamma 33 34
  • 57.39 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y69A2AR.18 33
  • 59.12 (n)
Y69A2AR.18 34
  • 41 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06886g 33
  • 54.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP3 33 34 36
  • 52.45 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL176W 33
  • 50.49 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATP3 33
  • 50.92 (n)
rice
(Oryza sativa)
Liliopsida Os10g0320400 33
  • 50.78 (n)
Os.10703 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp3 33
  • 50.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4089 34
  • 50 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU09119 33
  • 49.81 (n)
Species where no ortholog for ATP5F1C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5F1C Gene

ENSEMBL:
Gene Tree for ATP5F1C (if available)
TreeFam:
Gene Tree for ATP5F1C (if available)

Paralogs for ATP5F1C Gene

Pseudogenes.org Pseudogenes for ATP5F1C Gene

genes like me logo Genes that share paralogs with ATP5F1C: view

No data available for Paralogs for ATP5F1C Gene

Variants for ATP5F1C Gene

Sequence variations from dbSNP and Humsavar for ATP5F1C Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000178669 -- 7,803,006(+) G/T intron_variant
rs1000229562 -- 7,803,310(+) A/G intron_variant
rs1000483253 -- 7,789,570(+) C/T intron_variant
rs1000535708 -- 7,789,946(+) A/C intron_variant
rs1000911500 -- 7,805,696(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5F1C Gene

Variant ID Type Subtype PubMed ID
esv2671165 CNV deletion 23128226
esv3622277 CNV loss 21293372
nsv549933 CNV gain 21841781

Variation tolerance for ATP5F1C Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP5F1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5F1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5F1C Gene

Disorders for ATP5F1C Gene

Additional Disease Information for ATP5F1C

No disorders were found for ATP5F1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5F1C Gene

Publications for ATP5F1C Gene

  1. Gene structure of human mitochondrial ATP synthase gamma-subunit. Tissue specificity produced by alternative RNA splicing. (PMID: 8227057) Matsuda C … Kagawa Y (The Journal of biological chemistry 1993) 2 3 4 22 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier. (PMID: 8168843) Jabs EW … Pedersen PL (Human genetics 1994) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ATP5F1C Gene

Sources for ATP5F1C Gene

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