Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HEBP1 Gene

Aliases for HEBP1 Gene

  • Heme Binding Protein 1 2 3 5
  • P22HBP 3 4
  • HBP 3 4
  • Heme-Binding Protein 1 3
  • HEBP 3

External Ids for HEBP1 Gene

Previous GeneCards Identifiers for HEBP1 Gene

  • GC12M012858
  • GC12M013272
  • GC12M013028
  • GC12M013019
  • GC12M013128

Summaries for HEBP1 Gene

Entrez Gene Summary for HEBP1 Gene

  • The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for HEBP1 Gene

HEBP1 (Heme Binding Protein 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include heme binding. An important paralog of this gene is HEBP2.

UniProtKB/Swiss-Prot for HEBP1 Gene

  • May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.

Additional gene information for HEBP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEBP1 Gene

Genomics for HEBP1 Gene

GeneHancer (GH) Regulatory Elements for HEBP1 Gene

Promoters and enhancers for HEBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J012998 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 666.8 -0.2 -187 3.3 PKNOX1 SIN3A DMAP1 ZBTB7B ZNF48 YY1 GLIS2 SP3 SP5 REST HTR7P1 HEBP1 ENSG00000255621 GC12P013002
GH12J012999 Enhancer 0.2 ENCODE 650.7 +1.6 1629 0.1 ENSG00000255621 GC12M012990 HEBP1 HTR7P1
GH12J013193 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -202.8 -202783 19.5 PKNOX1 SIN3A FEZF1 YY1 ZNF143 FOS RXRA REST MAFF STAT3 EMP1 HTR7P1 MIR614 GSG1 DDX47 GPRC5D-AS1 ENSG00000255621 HEBP1 ENSG00000221611 LOH12CR2
GH12J012978 Enhancer 1 Ensembl ENCODE dbSUPER 24 +20.4 20363 2.9 RFX1 JUN SIN3A BMI1 RFX5 FOS FOSL2 MAFK NFE2L2 GPRC5D GC12P012980 HEBP1 MIR614 ENSG00000255621 HTR7P1 GPRC5D-AS1 DDX47 EMP1
GH12J013043 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.4 -44.2 -44195 1.4 ZNF133 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 YY1 ETS1 GLIS2 FAM234B GC12P013050 ENSG00000255621 HEBP1 HTR7P1 EMP1 MIR614
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HEBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HEBP1 gene promoter:
  • USF1
  • USF-1
  • Nkx2-5
  • C/EBPalpha
  • Max1
  • deltaCREB
  • CREB
  • c-Myc
  • FOXO4

Genomic Locations for HEBP1 Gene

Genomic Locations for HEBP1 Gene
chr12:12,974,864-13,000,309
(GRCh38/hg38)
Size:
25,446 bases
Orientation:
Minus strand
chr12:13,127,798-13,153,243
(GRCh37/hg19)
Size:
25,446 bases
Orientation:
Minus strand

Genomic View for HEBP1 Gene

Genes around HEBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HEBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HEBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEBP1 Gene

Proteins for HEBP1 Gene

  • Protein details for HEBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRV9-HEBP1_HUMAN
    Recommended name:
    Heme-binding protein 1
    Protein Accession:
    Q9NRV9
    Secondary Accessions:
    • A8K1G2
    • Q9Y5Z5

    Protein attributes for HEBP1 Gene

    Size:
    189 amino acids
    Molecular mass:
    21097 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for HEBP1 Gene

Post-translational modifications for HEBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HEBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HEBP1 Gene

Domains & Families for HEBP1 Gene

Gene Families for HEBP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HEBP1 Gene

Suggested Antigen Peptide Sequences for HEBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRV9

UniProtKB/Swiss-Prot:

HEBP1_HUMAN :
  • Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
  • Belongs to the HEBP family.
Domain:
  • Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
Family:
  • Belongs to the HEBP family.
genes like me logo Genes that share domains with HEBP1: view

Function for HEBP1 Gene

Molecular function for HEBP1 Gene

UniProtKB/Swiss-Prot Function:
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.

Gene Ontology (GO) - Molecular Function for HEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0020037 heme binding ISS --
genes like me logo Genes that share ontologies with HEBP1: view
genes like me logo Genes that share phenotypes with HEBP1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HEBP1 Gene

Localization for HEBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HEBP1 gene
Compartment Confidence
extracellular 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with HEBP1: view

Pathways & Interactions for HEBP1 Gene

genes like me logo Genes that share pathways with HEBP1: view

Gene Ontology (GO) - Biological Process for HEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007623 circadian rhythm TAS 10640688
genes like me logo Genes that share ontologies with HEBP1: view

No data available for SIGNOR curated interactions for HEBP1 Gene

Drugs & Compounds for HEBP1 Gene

(1) Drugs for HEBP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with HEBP1: view

Transcripts for HEBP1 Gene

mRNA/cDNA for HEBP1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(206) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HEBP1 Gene

Heme binding protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HEBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for HEBP1 Gene

GeneLoc Exon Structure for
HEBP1
ECgene alternative splicing isoforms for
HEBP1

Expression for HEBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HEBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HEBP1 Gene

This gene is overexpressed in Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HEBP1 Gene



Protein tissue co-expression partners for HEBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HEBP1 Gene:

HEBP1

SOURCE GeneReport for Unigene cluster for HEBP1 Gene:

Hs.642618

Evidence on tissue expression from TISSUES for HEBP1 Gene

  • Liver(4.4)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with HEBP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HEBP1 Gene

Orthologs for HEBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEBP1 34 33
  • 99.82 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HEBP1 34 33
  • 87.06 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HEBP1 34 33
  • 85.36 (n)
OneToMany
-- 34
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hebp1 33
  • 85.1 (n)
mouse
(Mus musculus)
Mammalia Hebp1 16 34 33
  • 83.87 (n)
oppossum
(Monodelphis domestica)
Mammalia HEBP1 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HEBP1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves HEBP1 34 33
  • 70.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HEBP1 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hebp1 33
  • 62.08 (n)
Str.10868 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23839 33
zebrafish
(Danio rerio)
Actinopterygii soul4 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2043 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
CSA.10114 34
  • 24 (a)
ManyToMany
Species where no ortholog for HEBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HEBP1 Gene

ENSEMBL:
Gene Tree for HEBP1 (if available)
TreeFam:
Gene Tree for HEBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HEBP1: view image

Paralogs for HEBP1 Gene

Paralogs for HEBP1 Gene

genes like me logo Genes that share paralogs with HEBP1: view

Variants for HEBP1 Gene

Sequence variations from dbSNP and Humsavar for HEBP1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005752 -- 12,985,834(-) C/T intron_variant
rs1000247209 -- 12,988,048(-) C/T intron_variant
rs1000298413 -- 13,002,120(-) T/A upstream_transcript_variant
rs1000305683 -- 12,993,134(-) C/G intron_variant
rs1000499875 -- 12,980,379(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HEBP1 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV deletion 23290073
nsv557607 CNV loss 21841781
nsv826260 CNV gain 20364138
nsv832333 CNV gain 17160897

Variation tolerance for HEBP1 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HEBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HEBP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HEBP1 Gene

Disorders for HEBP1 Gene

Additional Disease Information for HEBP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HEBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEBP1 Gene

Publications for HEBP1 Gene

  1. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. (PMID: 10640688) Zylka MJ … Reppert SM (Brain research. Molecular brain research 1999) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Characterization of a human and mouse tetrapyrrole-binding protein. (PMID: 12413491) Jacob Blackmon B … Dailey HA (Archives of biochemistry and biophysics 2002) 3 4 58

Products for HEBP1 Gene

Sources for HEBP1 Gene

Content
Loading form....