Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAS2R7 Gene

Aliases for TAS2R7 Gene

  • Taste 2 Receptor Member 7 2 3 5
  • Taste Receptor, Type 2, Member 7 2 3
  • T2R7 3 4
  • TRB4 3 4
  • Taste Receptor, Family B, Member 4 3
  • Taste Receptor Family B Member 4 4
  • Taste Receptor Type 2 Member 7 3

External Ids for TAS2R7 Gene

Previous GeneCards Identifiers for TAS2R7 Gene

  • GC12M010658
  • GC12M011098
  • GC12M010854
  • GC12M010845
  • GC12M010954

Summaries for TAS2R7 Gene

Entrez Gene Summary for TAS2R7 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R7 Gene

TAS2R7 (Taste 2 Receptor Member 7) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Taste transduction. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R9.

UniProtKB/Swiss-Prot for TAS2R7 Gene

  • Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Wiki entry for TAS2R7 Gene

Additional gene information for TAS2R7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R7 Gene

Genomics for TAS2R7 Gene

GeneHancer (GH) Regulatory Elements for TAS2R7 Gene

Promoters and enhancers for TAS2R7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I010802 Enhancer 0.3 ENCODE 550.8 +0.1 50 0.2 EZH2 TAS2R7 HSPE1P12
GH12I010891 Enhancer 0.9 ENCODE 10.5 -89.5 -89542 1.2 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 RXRA SP5 NFYC PRR4 LINC01252 TAS2R8 TAS2R7 TAS2R12P GC12P010842 ENSG00000275778 PRH1 PRH1-PRR4
GH12I010849 Promoter 0.5 EPDnew 11.1 -46.9 -46868 0.1 PRR4 TAS2R7 TAS2R8 ENSG00000256682 TAS2R13 ENSG00000256981 GC12P010842 TAS2R12P PRH1 PRH1-PRR4
GH12I010890 Enhancer 0.4 FANTOM5 2.9 -88.1 -88059 0.3 FOXA2 TAS2R20 TAS2R7 TAS2R13 TAS2R31 TAS2R14 TAS2R8 TAS2R12P GC12P010842 ENSG00000275778 PRH1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAS2R7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAS2R7 gene promoter:

Genomic Locations for TAS2R7 Gene

Genomic Locations for TAS2R7 Gene
chr12:10,801,532-10,802,627
(GRCh38/hg38)
Size:
1,096 bases
Orientation:
Minus strand
chr12:10,954,131-10,955,226
(GRCh37/hg19)

Genomic View for TAS2R7 Gene

Genes around TAS2R7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R7 Gene

Proteins for TAS2R7 Gene

  • Protein details for TAS2R7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW3-TA2R7_HUMAN
    Recommended name:
    Taste receptor type 2 member 7
    Protein Accession:
    Q9NYW3
    Secondary Accessions:
    • Q645Y1

    Protein attributes for TAS2R7 Gene

    Size:
    318 amino acids
    Molecular mass:
    36550 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell.

neXtProt entry for TAS2R7 Gene

Post-translational modifications for TAS2R7 Gene

  • Glycosylation at posLast=167167 and posLast=175175
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R7 Gene

Domains & Families for TAS2R7 Gene

Gene Families for TAS2R7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R7 Gene

Suggested Antigen Peptide Sequences for TAS2R7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYW3

UniProtKB/Swiss-Prot:

TA2R7_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R7: view

Function for TAS2R7 Gene

Molecular function for TAS2R7 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R7: view
genes like me logo Genes that share phenotypes with TAS2R7: view

Animal Model Products

CRISPR Products

miRNA for TAS2R7 Gene

miRTarBase miRNAs that target TAS2R7

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R7 Gene

Localization for TAS2R7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IC 20022913
genes like me logo Genes that share ontologies with TAS2R7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R7 Gene

Pathways & Interactions for TAS2R7 Gene

genes like me logo Genes that share pathways with TAS2R7: view

Pathways by source for TAS2R7 Gene

Gene Ontology (GO) - Biological Process for TAS2R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R7: view

No data available for SIGNOR curated interactions for TAS2R7 Gene

Drugs & Compounds for TAS2R7 Gene

(6) Drugs for TAS2R7 Gene - From: BitterDB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphenidol Approved, Investigational, Withdrawn Pharma 1
Papaverine Approved, Investigational Pharma 20
Quinine Approved Pharma Pore Blocker 47
Caffeine Approved Nutra Antagonist 434
calcium Approved Nutra 0

(1) Additional Compounds for TAS2R7 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cromolyn
genes like me logo Genes that share compounds with TAS2R7: view

Transcripts for TAS2R7 Gene

mRNA/cDNA for TAS2R7 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R7 Gene

Taste receptor, type 2, member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R7 Gene

No ASD Table

Relevant External Links for TAS2R7 Gene

GeneLoc Exon Structure for
TAS2R7
ECgene alternative splicing isoforms for
TAS2R7

Expression for TAS2R7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAS2R7 Gene:

TAS2R7

SOURCE GeneReport for Unigene cluster for TAS2R7 Gene:

Hs.533754

mRNA Expression by UniProt/SwissProt for TAS2R7 Gene:

Q9NYW3-TA2R7_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
genes like me logo Genes that share expression patterns with TAS2R7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R7 Gene

Orthologs for TAS2R7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R7 33 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia TAS2R7 33 34
  • 85.26 (n)
cow
(Bos Taurus)
Mammalia TAS2R7 33
  • 81.5 (n)
mouse
(Mus musculus)
Mammalia Tas2r130 33 16 34
  • 79.59 (n)
rat
(Rattus norvegicus)
Mammalia Tas2r130 33
  • 78.53 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
ManyToMany
T2R7A 34
  • 58 (a)
ManyToMany
T2R7B 34
  • 54 (a)
ManyToMany
Species where no ortholog for TAS2R7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R7 Gene

ENSEMBL:
Gene Tree for TAS2R7 (if available)
TreeFam:
Gene Tree for TAS2R7 (if available)

Paralogs for TAS2R7 Gene

genes like me logo Genes that share paralogs with TAS2R7: view

Variants for TAS2R7 Gene

Sequence variations from dbSNP and Humsavar for TAS2R7 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000608562 -- 10,804,373(-) C/T upstream_transcript_variant
rs1000749813 -- 10,804,551(-) T/C upstream_transcript_variant
rs1002018752 -- 10,803,303(-) G/T upstream_transcript_variant
rs1002686667 -- 10,803,008(-) T/C upstream_transcript_variant
rs1003078486 -- 10,804,019(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TAS2R7 Gene

Variant ID Type Subtype PubMed ID
esv3628543 CNV gain 21293372
nsv1044642 CNV gain 25217958
nsv976762 CNV duplication 23825009

Variation tolerance for TAS2R7 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAS2R7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R7 Gene

Disorders for TAS2R7 Gene

Additional Disease Information for TAS2R7

No disorders were found for TAS2R7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R7 Gene

Publications for TAS2R7 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E … Zuker CS (Cell 2000) 2 3 4 58
  2. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y … Ryba NJ (Cell 2003) 3 4 58
  5. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee RF (The Journal of biological chemistry 2002) 3 4 58

Products for TAS2R7 Gene

Sources for TAS2R7 Gene

Content
Loading form....