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Aliases for CALY Gene

Aliases for CALY Gene

  • Calcyon Neuron Specific Vesicular Protein 2 3 5
  • Dopamine Receptor D1 Interacting Protein 2 3
  • DRD1IP 3 4
  • Calcyon D1 Dopamine Receptor-Interacting Protein (CALCYON) 3
  • Neuron-Specific Vesicular Protein Calcyon 3
  • Calcyon Neuron-Specific Vesicular Protein 2
  • D1 Dopamine Receptor-Interacting Protein 3
  • Calcyon Protein 3
  • NSG3 3

External Ids for CALY Gene

Previous HGNC Symbols for CALY Gene

  • DRD1IP

Previous GeneCards Identifiers for CALY Gene

  • GC10M134989
  • GC10M135138
  • GC10M128683

Summaries for CALY Gene

Entrez Gene Summary for CALY Gene

  • The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]

GeneCards Summary for CALY Gene

CALY (Calcyon Neuron Specific Vesicular Protein) is a Protein Coding gene. Diseases associated with CALY include Attention Deficit-Hyperactivity Disorder and Schizophrenia. Among its related pathways are Circadian entrainment. Gene Ontology (GO) annotations related to this gene include clathrin light chain binding. An important paralog of this gene is NSG1.

UniProtKB/Swiss-Prot for CALY Gene

  • Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.

Gene Wiki entry for CALY Gene

Additional gene information for CALY Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALY Gene

Genomics for CALY Gene

GeneHancer (GH) Regulatory Elements for CALY Gene

Promoters and enhancers for CALY Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J133334 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.7 +1.2 1210 2.9 ATF1 SIN3A GLI4 GLIS2 KLF7 KLF13 SP3 ZNF518A RFX3 GMEB1 CALY SCART1 ZNF511 PAOX ECHS1 TUBGCP2 VENTX MTG1 FUOM GC10M133326
GH10J132392 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.6 +928.6 928569 32.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZBTB7B PWWP2B TUBGCP2 ENSG00000235245 C10orf91 ZNF511 STK32C LOC105378568 PAOX PPP2R2D MTG1
GH10J133329 Enhancer 1.3 FANTOM5 Ensembl ENCODE 0.4 +7.1 7068 1 ARID4B ZNF2 ZNF48 YY1 ZNF121 GLIS2 ZNF213 ARID2 ZNF143 KLF7 CFAP46 PRAP1 CALY GC10M133326 ZNF511-PRAP1
GH10J133324 Enhancer 1 Ensembl ENCODE 0.4 +11.7 11674 2.5 KLF1 SAP130 SUZ12 NFIB ZIC2 THRB E4F1 ZNF335 ZNF121 GLIS2 GC10M133326 VENTX ECHS1 CALY ZNF511-PRAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALY on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CALY gene promoter:
  • RFX1
  • MyoD
  • GATA-1
  • Zic1
  • Pax-5
  • Elk-1
  • HOXA3
  • GATA-2
  • deltaCREB

Genomic Locations for CALY Gene

Genomic Locations for CALY Gene
12,900 bases
Minus strand
11,549 bases
Minus strand

Genomic View for CALY Gene

Genes around CALY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALY Gene

Proteins for CALY Gene

  • Protein details for CALY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuron-specific vesicular protein calcyon
    Protein Accession:
    Secondary Accessions:
    • Q5VWX3
    • Q5VWY5
    • Q5VWY6

    Protein attributes for CALY Gene

    217 amino acids
    Molecular mass:
    23434 Da
    Quaternary structure:
    • Interacts with CLTA.

    Alternative splice isoforms for CALY Gene


neXtProt entry for CALY Gene

Post-translational modifications for CALY Gene

Other Protein References for CALY Gene

No data available for DME Specific Peptides for CALY Gene

Domains & Families for CALY Gene

Gene Families for CALY Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CALY Gene


Suggested Antigen Peptide Sequences for CALY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NSG family.
  • Belongs to the NSG family.
genes like me logo Genes that share domains with CALY: view

Function for CALY Gene

Molecular function for CALY Gene

UniProtKB/Swiss-Prot Function:
Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.

Phenotypes From GWAS Catalog for CALY Gene

Gene Ontology (GO) - Molecular Function for CALY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16595675
GO:0032051 clathrin light chain binding IDA 16595675
genes like me logo Genes that share ontologies with CALY: view
genes like me logo Genes that share phenotypes with CALY: view

Animal Models for CALY Gene

MGI Knock Outs for CALY:
  • Caly Caly<tm1.1Cber>

Animal Model Products

miRNA for CALY Gene

miRTarBase miRNAs that target CALY

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALY Gene

Localization for CALY Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALY Gene

Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALY gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CALY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 14534309
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with CALY: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALY Gene

Pathways & Interactions for CALY Gene

SuperPathway Contained pathways
1 Circadian entrainment
genes like me logo Genes that share pathways with CALY: view

Pathways by source for CALY Gene

1 KEGG pathway for CALY Gene

Interacting Proteins for CALY Gene

Gene Ontology (GO) - Biological Process for CALY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0016197 endosomal transport IBA --
GO:0045807 positive regulation of endocytosis IMP 16595675
GO:0048268 clathrin coat assembly IDA 16595675
genes like me logo Genes that share ontologies with CALY: view

No data available for SIGNOR curated interactions for CALY Gene

Drugs & Compounds for CALY Gene

(7) Drugs for CALY Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Apomorphine Approved, Investigational Pharma Antagonist, Partial agonist, Agonist, Full agonist, Activation, Activator, agonist, Target 40
Trifluoperazine Approved, Investigational Pharma Antagonist, inhibitor, Target, antagonist 5
calcium Approved Nutra 0
Clozapine Approved Pharma Antagonist, Positive, Allosteric regulator, Full agonist, Agonist, Inverse agonist, Target, unknown Antipsychotic medication 121
Dopamine Approved Pharma Full agonist, Agonist 4008
genes like me logo Genes that share compounds with CALY: view

Transcripts for CALY Gene

mRNA/cDNA for CALY Gene

Unigene Clusters for CALY Gene

Calcyon neuron-specific vesicular protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALY Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - - -
SP2: -
SP3: -

Relevant External Links for CALY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALY Gene

mRNA differential expression in normal tissues according to GTEx for CALY Gene

This gene is overexpressed in Brain - Hypothalamus (x9.4), Pituitary (x5.8), Brain - Nucleus accumbens (basal ganglia) (x4.9), Brain - Frontal Cortex (BA9) (x4.1), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for CALY Gene

This gene is overexpressed in Cerebrospinal fluid (44.3) and Plasma (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALY Gene

Protein tissue co-expression partners for CALY Gene

NURSA nuclear receptor signaling pathways regulating expression of CALY Gene:


SOURCE GeneReport for Unigene cluster for CALY Gene:


mRNA Expression by UniProt/SwissProt for CALY Gene:

Tissue specificity: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.

Evidence on tissue expression from TISSUES for CALY Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with CALY: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CALY Gene

Orthologs for CALY Gene

This gene was present in the common ancestor of mammals.

Orthologs for CALY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CALY 34 33
  • 99.15 (n)
(Canis familiaris)
Mammalia CALY 34 33
  • 89.32 (n)
(Mus musculus)
Mammalia Caly 16 34 33
  • 85.74 (n)
(Rattus norvegicus)
Mammalia Caly 33
  • 85.13 (n)
(Bos Taurus)
Mammalia CALY 34 33
  • 79.3 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
Species where no ortholog for CALY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CALY Gene

Gene Tree for CALY (if available)
Gene Tree for CALY (if available)
Evolutionary constrained regions (ECRs) for CALY: view image

Paralogs for CALY Gene

Paralogs for CALY Gene

(4) SIMAP similar genes for CALY Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALY: view

Variants for CALY Gene

Sequence variations from dbSNP and Humsavar for CALY Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000190134 -- 133,329,388(-) TCTTCT/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000240062 -- 133,334,738(-) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000421501 -- 133,336,341(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000679428 -- 133,328,032(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000981551 -- 133,327,764(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CALY Gene

Variant ID Type Subtype PubMed ID
dgv122n27 CNV loss 19166990
dgv1475n54 CNV loss 21841781
dgv2e196 CNV duplication 17116639
dgv3e196 CNV duplication 17116639
esv2750853 CNV gain 17911159
esv2759793 CNV gain+loss 17122850
esv3625030 CNV gain 21293372
esv3625042 CNV gain 21293372
esv3625043 CNV gain 21293372
esv3891901 CNV loss 25118596
nsv1037772 CNV gain 25217958
nsv1040726 CNV loss 25217958
nsv1052904 CNV gain 25217958
nsv1159786 CNV deletion 26073780
nsv428243 CNV gain 18775914
nsv467509 CNV loss 19166990
nsv470980 CNV loss 18288195
nsv528260 CNV loss 19592680
nsv552589 CNV gain 21841781
nsv552644 CNV loss 21841781
nsv825672 CNV gain 20364138
nsv832036 CNV loss 17160897
nsv832040 CNV loss 17160897
nsv8751 CNV gain 18304495
nsv952707 CNV deletion 24416366

Variation tolerance for CALY Gene

Gene Damage Index Score: 2.90; 48.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALY Gene

Disorders for CALY Gene

MalaCards: The human disease database

(2) MalaCards diseases for CALY Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • adhd
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search CALY in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CALY

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CALY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALY Gene

Publications for CALY Gene

  1. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. (PMID: 10698743) Lezcano N … Bergson C (Science (New York, N.Y.) 2000) 2 4 22 58
  2. Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking. (PMID: 25376768) Muthusamy N … Bergson C (Journal of neurochemistry 2015) 2 3 58
  3. Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A. (PMID: 19352218) Elia J … Hakonarson H (Psychiatric genetics 2009) 3 44 58
  4. Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD. (PMID: 17623072) Heijtz RD … Castellanos FX (Behavioral and brain functions : BBF 2007) 2 3 58
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58

Products for CALY Gene

Sources for CALY Gene

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