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Aliases for CLDN11 Gene

Aliases for CLDN11 Gene

  • Claudin 11 2 3 5
  • Oligodendrocyte Transmembrane Protein 2 3
  • Oligodendrocyte-Specific Protein 3 4
  • OTM 3 4
  • OSP 3 4
  • Claudin-11 3

External Ids for CLDN11 Gene

Previous HGNC Symbols for CLDN11 Gene

  • OTM

Previous GeneCards Identifiers for CLDN11 Gene

  • GC03P167279
  • GC03P171185
  • GC03P171538
  • GC03P171457
  • GC03P171619
  • GC03P170136
  • GC03P167506

Summaries for CLDN11 Gene

Entrez Gene Summary for CLDN11 Gene

  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

GeneCards Summary for CLDN11 Gene

CLDN11 (Claudin 11) is a Protein Coding gene. Diseases associated with CLDN11 include Lyme Disease and Adenoma Of The Pancreas. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is ENSG00000285218.

UniProtKB/Swiss-Prot for CLDN11 Gene

  • Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene Wiki entry for CLDN11 Gene

Additional gene information for CLDN11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLDN11 Gene

Genomics for CLDN11 Gene

GeneHancer (GH) Regulatory Elements for CLDN11 Gene

Promoters and enhancers for CLDN11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J170418 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 658.9 +1.4 1360 4.1 CTCF USF1 SAP130 MAX NFYC MIER2 NR2F2 ZNF664 POLR2A ZBTB33 CLDN11 ENSG00000285218 MECOM SLC7A14 MIR6828 ENSG00000242578
GH03J170433 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.4 +14.3 14278 0.1 CLDN11 MIR6828 ENSG00000285218 ENSG00000285051
GH03J170435 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.4 +14.7 14690 0.1 CLDN11 MIR6828 ENSG00000285218 ENSG00000285051
GH03J170808 Enhancer 1.4 FANTOM5 Ensembl ENCODE 16.5 +392.7 392673 6.6 HDGF PKNOX1 ARNT SIN3A ZNF2 ZNF766 E2F8 ZNF143 FOS DEK CLDN11 ENSG00000242578 RPL22L1 LOC101928583 EIF5A2 RNY5P3 LOC105374211 ENSG00000285051 ENSG00000285218
GH03J169771 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.7 -645.8 -645785 3.4 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MYNN TRV-AAC1-1 PIR36992 PHC3 SEC62-AS1 PRKCI CLDN11 LRRC34 ENSG00000270096 ENSG00000269889
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLDN11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLDN11 gene promoter:
  • CREB
  • deltaCREB
  • GATA-2
  • AML1a
  • GATA-3
  • GATA-1
  • Evi-1
  • USF-1
  • USF1

Genomic Locations for CLDN11 Gene

Genomic Locations for CLDN11 Gene
chr3:170,418,865-170,454,733
(GRCh38/hg38)
Size:
35,869 bases
Orientation:
Plus strand
chr3:170,136,653-170,578,169
(GRCh37/hg19)
Size:
441,517 bases
Orientation:
Plus strand

Genomic View for CLDN11 Gene

Genes around CLDN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLDN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLDN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLDN11 Gene

Proteins for CLDN11 Gene

  • Protein details for CLDN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75508-CLD11_HUMAN
    Recommended name:
    Claudin-11
    Protein Accession:
    O75508
    Secondary Accessions:
    • B2R7C1
    • D3DNQ5
    • Q5U0P3

    Protein attributes for CLDN11 Gene

    Size:
    207 amino acids
    Molecular mass:
    21993 Da
    Quaternary structure:
    • Interacts with tetraspanin-3/TSPAN3 (By similarity). Interacts with OCLN (PubMed:20375010).

neXtProt entry for CLDN11 Gene

Post-translational modifications for CLDN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLDN11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLDN11 Gene

Domains & Families for CLDN11 Gene

Gene Families for CLDN11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CLDN11 Gene

Suggested Antigen Peptide Sequences for CLDN11 Gene

Graphical View of Domain Structure for InterPro Entry

O75508

UniProtKB/Swiss-Prot:

CLD11_HUMAN :
  • Belongs to the claudin family.
Family:
  • Belongs to the claudin family.
genes like me logo Genes that share domains with CLDN11: view

Function for CLDN11 Gene

Molecular function for CLDN11 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Phenotypes From GWAS Catalog for CLDN11 Gene

Gene Ontology (GO) - Molecular Function for CLDN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 20375010
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with CLDN11: view
genes like me logo Genes that share phenotypes with CLDN11: view

Animal Models for CLDN11 Gene

MGI Knock Outs for CLDN11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLDN11 Gene

Localization for CLDN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLDN11 Gene

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLDN11 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CLDN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,IEA 20375010
GO:0005923 bicellular tight junction ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CLDN11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLDN11 Gene

Pathways & Interactions for CLDN11 Gene

genes like me logo Genes that share pathways with CLDN11: view

Gene Ontology (GO) - Biological Process for CLDN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS --
genes like me logo Genes that share ontologies with CLDN11: view

No data available for SIGNOR curated interactions for CLDN11 Gene

Drugs & Compounds for CLDN11 Gene

(1) Drugs for CLDN11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(1) Additional Compounds for CLDN11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLDN11: view

Transcripts for CLDN11 Gene

mRNA/cDNA for CLDN11 Gene

Unigene Clusters for CLDN11 Gene

Claudin 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLDN11

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLDN11 Gene

No ASD Table

Relevant External Links for CLDN11 Gene

GeneLoc Exon Structure for
CLDN11
ECgene alternative splicing isoforms for
CLDN11

Expression for CLDN11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLDN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLDN11 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.2) and Brain - Substantia nigra (x5.2).

Protein differential expression in normal tissues from HIPED for CLDN11 Gene

This gene is overexpressed in Frontal cortex (38.2) and Spinal cord (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLDN11 Gene



Protein tissue co-expression partners for CLDN11 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLDN11 Gene:

CLDN11

SOURCE GeneReport for Unigene cluster for CLDN11 Gene:

Hs.31595

Evidence on tissue expression from TISSUES for CLDN11 Gene

  • Nervous system(4.9)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with CLDN11: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLDN11 Gene

Orthologs for CLDN11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLDN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLDN11 34 33
  • 99.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CLDN11 34 33
  • 91.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CLDN11 34 33
  • 91.14 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLDN11 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cldn11 33
  • 87.44 (n)
mouse
(Mus musculus)
Mammalia Cldn11 16 34 33
  • 86.63 (n)
chicken
(Gallus gallus)
Aves CLDN11 34 33
  • 82.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLDN11 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cldn11 33
  • 70.05 (n)
zebrafish
(Danio rerio)
Actinopterygii cldn11a 34 33
  • 61.51 (n)
OneToMany
cldn11b 34
  • 39 (a)
OneToMany
Dr.12486 33
Species where no ortholog for CLDN11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLDN11 Gene

ENSEMBL:
Gene Tree for CLDN11 (if available)
TreeFam:
Gene Tree for CLDN11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLDN11: view image

Paralogs for CLDN11 Gene

Paralogs for CLDN11 Gene

(7) SIMAP similar genes for CLDN11 Gene using alignment to 2 proteins:

  • CLD11_HUMAN
  • B4DFI2_HUMAN
genes like me logo Genes that share paralogs with CLDN11: view

Variants for CLDN11 Gene

Sequence variations from dbSNP and Humsavar for CLDN11 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000108381 -- 170,430,608(+) C/T intron_variant
rs1000143310 -- 170,430,997(+) C/T intron_variant
rs1000957317 -- 170,424,263(+) G/A intron_variant
rs1001602750 -- 170,429,702(+) C/T intron_variant
rs1001636204 -- 170,419,971(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CLDN11 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER inversion 18451855

Variation tolerance for CLDN11 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLDN11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLDN11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLDN11 Gene

Disorders for CLDN11 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CLDN11 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lyme disease
  • bannwarth syndrome
adenoma of the pancreas
  • pancreatic adenoma
multiple sclerosis
  • multiple sclerosis, susceptibility to
squamous cell papilloma
  • epidermoid papilloma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CLDN11

genes like me logo Genes that share disorders with CLDN11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLDN11 Gene

Publications for CLDN11 Gene

  1. Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. (PMID: 10700007) Bronstein JM … Stevens DB (Journal of neuroscience research 2000) 3 4 22 58
  2. Chromosomal localization of murine and human oligodendrocyte-specific protein genes. (PMID: 8661061) Bronstein JM … Farber DB (Genomics 1996) 2 3 22 58
  3. Isolation and characterization of a novel oligodendrocyte-specific protein. (PMID: 8797478) Bronstein JM … Farber DB (Neurology 1996) 2 3 22 58
  4. Claudin association with CD81 defines hepatitis C virus entry. (PMID: 20375010) Harris HJ … McKeating JA (The Journal of biological chemistry 2010) 3 4 58
  5. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. (PMID: 19241088) Fink C … Brehm R (Histochemistry and cell biology 2009) 3 22 58

Products for CLDN11 Gene

Sources for CLDN11 Gene

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