Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ORM1 Gene

Aliases for ORM1 Gene

  • Orosomucoid 1 2 3 5
  • AGP 1 3 4
  • OMD 1 3 4
  • AGP1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 153w 3
  • Alpha-1-Acid Glycoprotein 1 3
  • Orosomucoid-1 4
  • HEL-S-153w 3
  • AGP-A 3
  • ORM 3

External Ids for ORM1 Gene

Previous GeneCards Identifiers for ORM1 Gene

  • GC09P107883
  • GC09P108817
  • GC09P022002
  • GC09P112461
  • GC09P114164
  • GC09P116125
  • GC09P117085
  • GC09P086691

Summaries for ORM1 Gene

Entrez Gene Summary for ORM1 Gene

  • This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

GeneCards Summary for ORM1 Gene

ORM1 (Orosomucoid 1) is a Protein Coding gene. Diseases associated with ORM1 include Dry Eye Syndrome and Pediatric Multiple Sclerosis. Among its related pathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is ORM2.

UniProtKB/Swiss-Prot for ORM1 Gene

  • Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

Gene Wiki entry for ORM1 Gene

Additional gene information for ORM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORM1 Gene

Genomics for ORM1 Gene

GeneHancer (GH) Regulatory Elements for ORM1 Gene

Promoters and enhancers for ORM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J114314 Promoter/Enhancer 1.5 EPDnew FANTOM5 ENCODE 671 -7.8 -7796 0.5 FOXA2 TAF1 MAX RAD21 YY1 EGR1 HNF4G ZNF189 RXRA HLF ORM1 AMBP ORM2 LOC105376224 MIR455
GH09J114323 Promoter 0.5 EPDnew 650.7 +0.0 20 0.1 ORM1 ORM2
GH09J114321 Enhancer 0.4 ENCODE 650.7 -1.1 -1067 0.2 JUND FOS ORM1 ORM2 WHRN LOC105376224
GH09J114360 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.9 +53.1 53113 30.6 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 SIN3A YBX1 IRF4 YY1 POLR2B AKNA WHRN TMEM268 ENSG00000201749 ORM1 ORM2 ATP6V1G1 ENSG00000235119
GH09J113992 Enhancer 1.1 FANTOM5 Ensembl ENCODE 6.4 -330.2 -330174 1.1 RXRA MAX REST RAD21 FOXA1 GABPA NR2F2 YY1 SP1 JUND ORM2 AMBP ORM1 COL27A1 GC09P114791 ZNF618
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ORM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ORM1 gene promoter:
  • C/EBPalpha
  • Pax-4a
  • AML1a
  • Brachyury
  • NCX
  • STAT1
  • NF-E2 p45
  • NF-E2

Genomic Locations for ORM1 Gene

Genomic Locations for ORM1 Gene
chr9:114,323,023-114,326,479
(GRCh38/hg38)
Size:
3,457 bases
Orientation:
Plus strand
chr9:117,085,303-117,088,759
(GRCh37/hg19)
Size:
3,457 bases
Orientation:
Plus strand

Genomic View for ORM1 Gene

Genes around ORM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORM1 Gene

Proteins for ORM1 Gene

  • Protein details for ORM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02763-A1AG1_HUMAN
    Recommended name:
    Alpha-1-acid glycoprotein 1
    Protein Accession:
    P02763
    Secondary Accessions:
    • B7ZKQ5
    • Q5T539
    • Q5U067
    • Q8TC16

    Protein attributes for ORM1 Gene

    Size:
    201 amino acids
    Molecular mass:
    23512 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA29229.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ORM1 Gene

neXtProt entry for ORM1 Gene

Post-translational modifications for ORM1 Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
  • Glycosylation at Asn103, Asn93, Asn72, isoforms=56, and isoforms=33
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for ORM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ORM1 Gene

Domains & Families for ORM1 Gene

Gene Families for ORM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ORM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02763

UniProtKB/Swiss-Prot:

A1AG1_HUMAN :
  • Contains a beta-barrel that binds various ligands in its interior.
  • Belongs to the calycin superfamily. Lipocalin family.
Domain:
  • Contains a beta-barrel that binds various ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with ORM1: view

Function for ORM1 Gene

Molecular function for ORM1 Gene

UniProtKB/Swiss-Prot Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
UniProtKB/Swiss-Prot Induction:
Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.
GENATLAS Biochemistry:
orosomucoid 1 (lipocalin family,outlier group),abundant in plasma

Phenotypes From GWAS Catalog for ORM1 Gene

Gene Ontology (GO) - Molecular Function for ORM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16272158
genes like me logo Genes that share ontologies with ORM1: view
genes like me logo Genes that share phenotypes with ORM1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ORM1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ORM1 Gene

Localization for ORM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORM1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORM1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ORM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA --
GO:0005615 extracellular space TAS,IDA 8774350
GO:0031012 extracellular matrix IDA 27559042
GO:0031093 platelet alpha granule lumen TAS --
GO:0035580 specific granule lumen TAS --
genes like me logo Genes that share ontologies with ORM1: view

Pathways & Interactions for ORM1 Gene

genes like me logo Genes that share pathways with ORM1: view

Gene Ontology (GO) - Biological Process for ORM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0002682 regulation of immune system process IEA --
GO:0006953 acute-phase response IEA,TAS --
GO:0006954 inflammatory response TAS 3360326
GO:0032715 negative regulation of interleukin-6 production IDA 23973664
genes like me logo Genes that share ontologies with ORM1: view

No data available for SIGNOR curated interactions for ORM1 Gene

Drugs & Compounds for ORM1 Gene

(73) Drugs for ORM1 Gene - From: DrugBank and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vandetanib Approved April 2011 Pharma Carrier, binder VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
abemaciclib Approved, Investigational Pharma Carrier, binder 0
Abiraterone Approved Pharma Carrier, substrate Potent CYP17 inhibitor 0
Acenocoumarol Approved, Investigational Pharma Carrier 35
Alfentanil Approved, Illicit Pharma Carrier 38

(1) Additional Compounds for ORM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ORM1: view

Transcripts for ORM1 Gene

mRNA/cDNA for ORM1 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(657) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ORM1 Gene

Orosomucoid 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORM1 Gene

No ASD Table

Relevant External Links for ORM1 Gene

GeneLoc Exon Structure for
ORM1
ECgene alternative splicing isoforms for
ORM1

Expression for ORM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ORM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORM1 Gene

This gene is overexpressed in Liver (x52.3).

Protein differential expression in normal tissues from HIPED for ORM1 Gene

This gene is overexpressed in Synovial fluid (9.4), Plasma (9.3), and Serum (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ORM1 Gene



Protein tissue co-expression partners for ORM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ORM1 Gene:

ORM1

SOURCE GeneReport for Unigene cluster for ORM1 Gene:

Hs.522356

mRNA Expression by UniProt/SwissProt for ORM1 Gene:

P02763-A1AG1_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for ORM1 Gene

  • Liver(5)
  • Bone marrow(4.4)
  • Nervous system(4.2)
  • Saliva(4)
  • Blood(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with ORM1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ORM1 Gene

Orthologs for ORM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ORM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORM1 33
  • 98.18 (n)
dog
(Canis familiaris)
Mammalia ORM1 33
  • 70.74 (n)
-- 34
  • 55 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ORM1 33
  • 70.56 (n)
AGP 34
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Orm1 33
  • 65.14 (n)
mouse
(Mus musculus)
Mammalia Orm1 34
  • 49 (a)
ManyToMany
Orm2 34
  • 45 (a)
ManyToMany
Orm3 34
  • 44 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 41 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves OGCHI 34
  • 25 (a)
OneToMany
Species where no ortholog for ORM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ORM1 Gene

ENSEMBL:
Gene Tree for ORM1 (if available)
TreeFam:
Gene Tree for ORM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ORM1: view image

Paralogs for ORM1 Gene

Paralogs for ORM1 Gene

(1) SIMAP similar genes for ORM1 Gene using alignment to 2 proteins:

  • A1AG1_HUMAN
  • F5H794_HUMAN
genes like me logo Genes that share paralogs with ORM1: view

Variants for ORM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ORM1 Gene

A1AG1_HUMAN-P02763
Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and ORM1*S has Arg-38/Val-174. The sequence shown is that of allele ORM1*F1.

Sequence variations from dbSNP and Humsavar for ORM1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001386903 -- 114,326,506(+) A/C downstream_transcript_variant
rs1002904532 -- 114,321,228(+) A/G upstream_transcript_variant
rs1002956843 -- 114,321,063(+) G/A upstream_transcript_variant
rs1003290596 -- 114,321,864(+) C/A upstream_transcript_variant
rs1003468004 -- 114,324,717(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ORM1 Gene

Variant ID Type Subtype PubMed ID
dgv1233n67 CNV gain 20364138
dgv12859n54 CNV gain 21841781
dgv12860n54 CNV gain 21841781
dgv12861n54 CNV gain 21841781
dgv1503e214 CNV gain 21293372
dgv2181e212 CNV gain 25503493
dgv2182e212 CNV gain 25503493
dgv33e196 CNV duplication 17116639
dgv7706n100 CNV gain 25217958
dgv948n27 CNV gain 19166990
dgv949n27 CNV gain 19166990
esv22321 CNV gain 19812545
esv2664309 CNV deletion 23128226
esv2752277 CNV gain 17911159
esv2761285 CNV gain 21179565
esv33804 CNV gain+loss 17666407
esv3442507 CNV duplication 20981092
esv3576696 CNV gain 25503493
esv3576701 CNV gain 25503493
esv3621549 CNV gain 21293372
esv3621554 CNV loss 21293372
nsv1110578 CNV duplication 24896259
nsv471320 CNV gain 18288195
nsv509319 CNV insertion 20534489
nsv528823 CNV gain 19592680
nsv615233 CNV gain 21841781
nsv968749 CNV duplication 23825009

Variation tolerance for ORM1 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ORM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORM1

SNP Genotyping and Copy Number Assay Products

Disorders for ORM1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ORM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dry eye syndrome
  • xerophthalmia
pediatric multiple sclerosis
  • ms pediatric
odontogenic myxoma
- elite association - COSMIC cancer census association via MalaCards
Search ORM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ORM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ORM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ORM1 Gene

Publications for ORM1 Gene

  1. Orosomucoid influences the response to antidepressants in major depressive disorder. (PMID: 19395425) Harley J … Kennedy M (Journal of psychopharmacology (Oxford, England) 2010) 3 22 44 58
  2. Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S. (PMID: 9050929) Yuasa I … Irizawa Y (Human genetics 1997) 3 4 22 58
  3. The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. (PMID: 20959405) Kim DH … Lipton JH (Clinical cancer research : an official journal of the American Association for Cancer Research 2010) 3 44 58
  4. Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients. (PMID: 19794411) Pautas E … Siguret V (Clinical pharmacology and therapeutics 2010) 3 44 58
  5. Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia. (PMID: 19141860) Kim DH … Lipton JH (Blood 2009) 3 44 58

Products for ORM1 Gene

  • Boster Bio Antibodies for ORM1
  • Boster Bio ELISA Kits for ORM1

Sources for ORM1 Gene

Content
Loading form....