Aliases for NTF4 Gene
External Ids for NTF4 Gene
Previous HGNC Symbols for NTF4 Gene
Previous GeneCards Identifiers for NTF4 Gene
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
GeneCards Summary for NTF4 Gene
NTF4 (Neurotrophin 4) is a Protein Coding gene. Diseases associated with NTF4 include Glaucoma 1, Open Angle, O and Hypochondriasis. Among its related pathways are ERK Signaling and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neurotrophin p75 receptor binding. An important paralog of this gene is BDNF.
UniProtKB/Swiss-Prot for NTF4 Gene
Target-derived survival factor for peripheral sensory sympathetic neurons.