Aliases for NTF3 Gene
External Ids for NTF3 Gene
Previous GeneCards Identifiers for NTF3 Gene
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
GeneCards Summary for NTF3 Gene
NTF3 (Neurotrophin 3) is a Protein Coding gene. Diseases associated with NTF3 include Hypochondriasis and Diabetic Polyneuropathy. Among its related pathways are ERK Signaling and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemoattractant activity. An important paralog of this gene is NGF.
UniProtKB/Swiss-Prot for NTF3 Gene
Seems to promote the survival of visceral and proprioceptive sensory neurons.