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Aliases for NTF3 Gene

Aliases for NTF3 Gene

  • Neurotrophin 3 2 3 5
  • Nerve Growth Factor 2 3 4
  • Neurotrophic Factor 3 4
  • NGF-2 3 4
  • HDNF 3 4
  • NT-3 3 4
  • Neurotrophin-3 3
  • NGF2 3
  • NT3 3

External Ids for NTF3 Gene

Previous GeneCards Identifiers for NTF3 Gene

  • GC12U990064
  • GC12P005487
  • GC12P005420
  • GC12P005473
  • GC12P005541

Summaries for NTF3 Gene

Entrez Gene Summary for NTF3 Gene

  • The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTF3 Gene

NTF3 (Neurotrophin 3) is a Protein Coding gene. Diseases associated with NTF3 include Hypochondriasis and Diabetic Polyneuropathy. Among its related pathways are ERK Signaling and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemoattractant activity. An important paralog of this gene is NGF.

UniProtKB/Swiss-Prot for NTF3 Gene

  • Seems to promote the survival of visceral and proprioceptive sensory neurons.

Gene Wiki entry for NTF3 Gene

Additional gene information for NTF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTF3 Gene

Genomics for NTF3 Gene

GeneHancer (GH) Regulatory Elements for NTF3 Gene

Promoters and enhancers for NTF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J005429 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 666.6 +0.1 75 6 ZSCAN4 YY1 ZNF335 GLIS2 EGR1 SCRT2 EGR2 RXRA ZBTB11 ZNF398 NTF3 LOC105369620 KCNA5 GC12M005446
GH12J004537 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.3 -893.1 -893115 3 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 RAD51AP1 C12orf4 NTF3 GC12M004550
GH12J006166 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +736.0 735978 3.9 PKNOX1 ATF1 ARNT TCF12 ZNF766 ZNF207 ZNF143 ATF7 FOS RUNX3 PIR38862 CD9 VWF ATN1 NTF3 TNFRSF1A TAPBPL VAMP1 PIR39839 LOC105369623
GH12J005455 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +24.9 24907 2.8 RFX1 POLR2A ZBTB33 BMI1 SPI1 NTF3 GC12M005446 GC12P005796
GH12J005496 Enhancer 0.8 ENCODE dbSUPER 11.2 +66.9 66938 4.6 RXRA MAX GABPA YY1 SP1 JUND ATF3 HNF4G ZBTB33 HNF4A NTF3 GC12M005501 GC12M005461
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NTF3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NTF3 gene promoter:
  • AP-1
  • CREB
  • c-Jun
  • ATF-2
  • deltaCREB
  • GR-alpha
  • GR
  • LyF-1
  • c-Ets-1

Genomic Locations for NTF3 Gene

Genomic Locations for NTF3 Gene
chr12:5,432,112-5,521,536
(GRCh38/hg38)
Size:
89,425 bases
Orientation:
Plus strand
chr12:5,541,278-5,630,702
(GRCh37/hg19)
Size:
89,425 bases
Orientation:
Plus strand

Genomic View for NTF3 Gene

Genes around NTF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTF3 Gene

Proteins for NTF3 Gene

  • Protein details for NTF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20783-NTF3_HUMAN
    Recommended name:
    Neurotrophin-3
    Protein Accession:
    P20783
    Secondary Accessions:
    • B7Z1T5
    • Q6FH50

    Protein attributes for NTF3 Gene

    Size:
    257 amino acids
    Molecular mass:
    29355 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NTF3 Gene

    Alternative splice isoforms for NTF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTF3 Gene

Post-translational modifications for NTF3 Gene

  • Glycosylation at Asn131
  • Modification sites at PhosphoSitePlus

Other Protein References for NTF3 Gene

No data available for DME Specific Peptides for NTF3 Gene

Domains & Families for NTF3 Gene

Gene Families for NTF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for NTF3 Gene

Graphical View of Domain Structure for InterPro Entry

P20783

UniProtKB/Swiss-Prot:

NTF3_HUMAN :
  • Belongs to the NGF-beta family.
Family:
  • Belongs to the NGF-beta family.
genes like me logo Genes that share domains with NTF3: view

Function for NTF3 Gene

Molecular function for NTF3 Gene

UniProtKB/Swiss-Prot Function:
Seems to promote the survival of visceral and proprioceptive sensory neurons.
GENATLAS Biochemistry:
neurotrophic factor (neurotrophin) 3,29.3kDa,ligand for NTRK3 (TRKC),expressed in retina and the anterior segment of the developing eye

Phenotypes From GWAS Catalog for NTF3 Gene

Gene Ontology (GO) - Molecular Function for NTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 2236018
GO:0005165 neurotrophin receptor binding IEA --
GO:0005166 neurotrophin p75 receptor binding IBA --
GO:0005515 protein binding IPI 18596692
GO:0008083 growth factor activity IDA 23027130
genes like me logo Genes that share ontologies with NTF3: view
genes like me logo Genes that share phenotypes with NTF3: view

Animal Models for NTF3 Gene

MGI Knock Outs for NTF3:

Animal Model Products

miRNA for NTF3 Gene

miRTarBase miRNAs that target NTF3

Clone Products

  • Addgene plasmids for NTF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTF3 Gene

Localization for NTF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTF3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTF3 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA --
GO:0005615 extracellular space IBA --
GO:0008021 synaptic vesicle IBA --
GO:0030424 axon IBA --
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with NTF3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NTF3 Gene

Pathways & Interactions for NTF3 Gene

genes like me logo Genes that share pathways with NTF3: view

SIGNOR curated interactions for NTF3 Gene

Activates:

Gene Ontology (GO) - Biological Process for NTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 23027130
GO:0002092 positive regulation of receptor internalization IDA 23027130
GO:0007165 signal transduction TAS 2236018
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA 23027130
GO:0007267 cell-cell signaling TAS 2236018
genes like me logo Genes that share ontologies with NTF3: view

Drugs & Compounds for NTF3 Gene

(46) Drugs for NTF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(28) Additional Compounds for NTF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NTF3: view

Transcripts for NTF3 Gene

mRNA/cDNA for NTF3 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NTF3 Gene

Neurotrophin 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for NTF3

Alternative Splicing Database (ASD) splice patterns (SP) for NTF3 Gene

No ASD Table

Relevant External Links for NTF3 Gene

GeneLoc Exon Structure for
NTF3
ECgene alternative splicing isoforms for
NTF3

Expression for NTF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTF3 Gene

mRNA differential expression in normal tissues according to GTEx for NTF3 Gene

This gene is overexpressed in Artery - Tibial (x8.1), Artery - Aorta (x6.2), and Artery - Coronary (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NTF3 Gene



NURSA nuclear receptor signaling pathways regulating expression of NTF3 Gene:

NTF3

SOURCE GeneReport for Unigene cluster for NTF3 Gene:

Hs.99171

mRNA Expression by UniProt/SwissProt for NTF3 Gene:

P20783-NTF3_HUMAN
Tissue specificity: Brain and peripheral tissues.

Evidence on tissue expression from TISSUES for NTF3 Gene

  • Nervous system(4.7)
  • Blood(4.2)
  • Muscle(2.3)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with NTF3: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTF3 Gene

Orthologs for NTF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTF3 34 33
  • 98.7 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTF3 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTF3 34 33
  • 92.1 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntf3 33
  • 90.62 (n)
mouse
(Mus musculus)
Mammalia Ntf3 16 34 33
  • 90 (n)
cow
(Bos Taurus)
Mammalia NTF3 34 33
  • 89.68 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NT-3 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTF3 34 33
  • 78.89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTF3 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntf3 33
  • 73.28 (n)
Str.3752 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1074 33
zebrafish
(Danio rerio)
Actinopterygii ntf3 34 33
  • 59.48 (n)
OneToOne
Species where no ortholog for NTF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTF3 Gene

ENSEMBL:
Gene Tree for NTF3 (if available)
TreeFam:
Gene Tree for NTF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NTF3: view image

Paralogs for NTF3 Gene

Paralogs for NTF3 Gene

(3) SIMAP similar genes for NTF3 Gene using alignment to 1 proteins:

  • NTF3_HUMAN
genes like me logo Genes that share paralogs with NTF3: view

Variants for NTF3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NTF3 Gene

NTF3_HUMAN-P20783
Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.

Sequence variations from dbSNP and Humsavar for NTF3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs540320780 uncertain-significance, Hirschsprung disease 1 5,494,440(+) G/A coding_sequence_variant, missense_variant
rs1000021071 -- 5,453,330(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000075380 -- 5,460,408(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000114211 -- 5,474,007(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000135888 -- 5,469,381(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NTF3 Gene

Variant ID Type Subtype PubMed ID
dgv1348n100 CNV gain 25217958
esv2559368 CNV insertion 19546169
esv3358188 CNV duplication 20981092
nsv1040098 CNV gain 25217958
nsv1051126 CNV gain 25217958
nsv1110206 CNV duplication 24896259
nsv1152910 CNV duplication 26484159
nsv468988 CNV gain 19166990
nsv470262 CNV gain 18288195
nsv473788 CNV novel sequence insertion 20440878
nsv478052 CNV novel sequence insertion 20440878
nsv513347 CNV insertion 21212237
nsv523152 CNV gain 19592680
nsv524170 CNV gain 19592680
nsv557155 CNV gain 21841781
nsv592 CNV insertion 18451855

Variation tolerance for NTF3 Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.35; 70.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTF3 Gene

Human Gene Mutation Database (HGMD)
NTF3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTF3

SNP Genotyping and Copy Number Assay Products

Disorders for NTF3 Gene

MalaCards: The human disease database

(22) MalaCards diseases for NTF3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypochondriasis
  • hypochondria
diabetic polyneuropathy
  • diabetes mellitus with polyneuropathy
diabetic neuropathy
  • diabetic neuropathies
diabetic autonomic neuropathy
  • diabetic neuropathies
demyelinating disease
  • demyelinating disorder
- elite association - COSMIC cancer census association via MalaCards
Search NTF3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NTF3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NTF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTF3 Gene

Publications for NTF3 Gene

  1. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PMID: 1889806) Maisonpierre PC … Yancopoulos GD (Genomics 1991) 2 3 4 22 58
  2. Association of neurotrophin-3 gene variant with severe forms of schizophrenia. (PMID: 7733919) Hattori M … Nanko S (Biochemical and biophysical research communications 1995) 3 4 44 58
  3. Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes. (PMID: 20060128) Fernandes BS … Kapczinski F (Journal of psychiatric research 2010) 3 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. NT-3 gene modified Schwann cells promote TrkC gene modified mesenchymal stem cells to differentiate into neuron-like cells in vitro. (PMID: 19680743) Zhang YQ … Zeng YS (Anatomical science international 2010) 3 22 58

Products for NTF3 Gene

  • Addgene plasmids for NTF3

Sources for NTF3 Gene

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