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Aliases for NKTR Gene

Aliases for NKTR Gene

  • Natural Killer Cell Triggering Receptor 2 3 5
  • Natural-Killer Cells Cyclophilin-Related Protein 2 3 4
  • NK-TR Protein 2 3 4
  • Natural Killer-Tumor Recognition Sequence 2 3
  • NK-Tumor Recognition Protein 2 3
  • Natural Killer Triggering Receptor 3
  • P104 3

External Ids for NKTR Gene

Previous GeneCards Identifiers for NKTR Gene

  • GC03P041946
  • GC03P041822
  • GC03P042461
  • GC03P042602
  • GC03P042617

Summaries for NKTR Gene

Entrez Gene Summary for NKTR Gene

  • This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for NKTR Gene

NKTR (Natural Killer Cell Triggering Receptor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPIG.

UniProtKB/Swiss-Prot for NKTR Gene

  • Component of a putative tumor-recognition complex. Involved in the function of NK cells.

Gene Wiki entry for NKTR Gene

Additional gene information for NKTR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKTR Gene

Genomics for NKTR Gene

GeneHancer (GH) Regulatory Elements for NKTR Gene

Promoters and enhancers for NKTR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J042599 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 727.9 +0.5 521 3.8 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 NKTR SEC22C SNRK-AS1 ZBTB47 LOC101928323
GH03J042589 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 697.6 -9.6 -9648 2.5 HDGF PKNOX1 ATF1 IRF4 BRCA1 YY1 GTF3C2 POLR2B GLIS2 ZNF207 NKTR SS18L2 SEC22C CCDC13-AS1 CCDC13 SNRK-AS1
GH03J042011 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 52 -586.2 -586208 5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A IRF4 YY1 POLR2B ZNF766 TRAK1 NKTR ULK4 CTNNB1 ZNF662 ENSG00000229339
GH03J042501 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38 -93.6 -93605 10.5 PKNOX1 ATF1 SIN3A FOS SP3 RXRA NFYC REST SMARCA4 PBX2 VIPR1 NKTR SEC22C VIPR1-AS1 SNRK-AS1 SS18L2 ZNF662 CCDC13-AS1
GH03J042650 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 47.4 +53.2 53214 6.4 HDGF PKNOX1 ARNT ZFP64 SIN3A DMAP1 POLR2B CBX5 FOS SP3 LOC101928323 ZBTB47 NKTR SEC22C SNRK-AS1 SS18L2 HHATL FAM198A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NKTR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NKTR gene promoter:
  • HEN1
  • AP-4

Genomic Locations for NKTR Gene

Genomic Locations for NKTR Gene
chr3:42,600,614-42,648,741
(GRCh38/hg38)
Size:
48,128 bases
Orientation:
Plus strand
chr3:42,642,106-42,690,233
(GRCh37/hg19)
Size:
48,128 bases
Orientation:
Plus strand

Genomic View for NKTR Gene

Genes around NKTR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKTR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKTR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKTR Gene

Proteins for NKTR Gene

  • Protein details for NKTR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30414-NKTR_HUMAN
    Recommended name:
    NK-tumor recognition protein
    Protein Accession:
    P30414

    Protein attributes for NKTR Gene

    Size:
    1462 amino acids
    Molecular mass:
    165677 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NKTR Gene

neXtProt entry for NKTR Gene

Post-translational modifications for NKTR Gene

  • Ubiquitination at Lys1258
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NKTR Gene

Domains & Families for NKTR Gene

Gene Families for NKTR Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NKTR: view

No data available for UniProtKB/Swiss-Prot for NKTR Gene

Function for NKTR Gene

Molecular function for NKTR Gene

UniProtKB/Swiss-Prot Function:
Component of a putative tumor-recognition complex. Involved in the function of NK cells.
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
GENATLAS Biochemistry:
natural killer triggering receptor

Phenotypes From GWAS Catalog for NKTR Gene

Gene Ontology (GO) - Molecular Function for NKTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA,IBA --
GO:0016018 cyclosporin A binding TAS 8421688
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with NKTR: view
genes like me logo Genes that share phenotypes with NKTR: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NKTR

Clone Products

  • Addgene plasmids for NKTR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKTR Gene

Localization for NKTR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKTR Gene

Membrane; Peripheral membrane protein. Note=Attached to the membrane via its N-terminus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKTR gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NKTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NKTR: view

Pathways & Interactions for NKTR Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with NKTR: view

No data available for Pathways by source and SIGNOR curated interactions for NKTR Gene

Drugs & Compounds for NKTR Gene

No Compound Related Data Available

Transcripts for NKTR Gene

Unigene Clusters for NKTR Gene

Natural killer-tumor recognition sequence:
Representative Sequences:

Clone Products

  • Addgene plasmids for NKTR

Alternative Splicing Database (ASD) splice patterns (SP) for NKTR Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8: -
SP9:
SP10:
SP11:

ExUns: 17a · 17b ^ 18a · 18b · 18c
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NKTR Gene

GeneLoc Exon Structure for
NKTR
ECgene alternative splicing isoforms for
NKTR

Expression for NKTR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKTR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NKTR Gene

This gene is overexpressed in Heart (45.8) and Cerebrospinal fluid (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NKTR Gene



Protein tissue co-expression partners for NKTR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NKTR Gene:

NKTR

SOURCE GeneReport for Unigene cluster for NKTR Gene:

Hs.529509

Evidence on tissue expression from TISSUES for NKTR Gene

  • Gall bladder(5)
  • Blood(4.8)
  • Liver(4.3)
  • Nervous system(3.8)
  • Intestine(3.6)
genes like me logo Genes that share expression patterns with NKTR: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKTR Gene

Orthologs for NKTR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NKTR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKTR 34 33
  • 99.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NKTR 34 33
  • 90.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NKTR 34 33
  • 90.18 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nktr 16 34 33
  • 81.89 (n)
rat
(Rattus norvegicus)
Mammalia Nktr 33
  • 79.27 (n)
oppossum
(Monodelphis domestica)
Mammalia NKTR 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKTR 34 33
  • 68.08 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NKTR 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nktr 34
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Moca-cyp 34
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyp-8 35
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 34
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3359 34
  • 51 (a)
OneToMany
Species where no ortholog for NKTR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NKTR Gene

ENSEMBL:
Gene Tree for NKTR (if available)
TreeFam:
Gene Tree for NKTR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NKTR: view image

Paralogs for NKTR Gene

Paralogs for NKTR Gene

(25) SIMAP similar genes for NKTR Gene using alignment to 3 proteins:

  • NKTR_HUMAN
  • A8K7K2_HUMAN
  • C9JMM5_HUMAN
genes like me logo Genes that share paralogs with NKTR: view

Variants for NKTR Gene

Sequence variations from dbSNP and Humsavar for NKTR Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000096676 -- 42,635,362(+) G/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000222763 -- 42,649,071(+) C/T downstream_transcript_variant
rs1000294934 -- 42,617,421(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000315928 -- 42,608,563(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000346802 -- 42,617,851(+) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NKTR Gene

Variant ID Type Subtype PubMed ID
nsv3781 CNV insertion 18451855

Variation tolerance for NKTR Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKTR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKTR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKTR Gene

Disorders for NKTR Gene

Additional Disease Information for NKTR

No disorders were found for NKTR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKTR Gene

Publications for NKTR Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Expression of the NK-TR gene is required for NK-like activity in human T cells. (PMID: 8144875) Chambers CA … Roder J (Journal of immunology (Baltimore, Md. : 1950) 1994) 2 3 58
  3. Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9. (PMID: 8314596) Young HA … Anderson SK (Genomics 1993) 2 3 58
  4. A cyclophilin-related protein involved in the function of natural killer cells. (PMID: 8421688) Anderson SK … Ortaldo JR (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 58
  5. IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism. (PMID: 8413330) Rinfret A … Anderson SK (Molecular immunology 1993) 3 22 58

Products for NKTR Gene

  • Addgene plasmids for NKTR

Sources for NKTR Gene

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