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Aliases for NGF Gene

Aliases for NGF Gene

  • Nerve Growth Factor 2 3 5
  • Nerve Growth Factor (Beta Polypeptide) 2 3
  • Beta-NGF 3 4
  • NGFB 3 4
  • Nerve Growth Factor, Beta Subunit 3
  • Beta-Nerve Growth Factor 3
  • HSAN5 3

External Ids for NGF Gene

Previous HGNC Symbols for NGF Gene

  • NGFB

Previous GeneCards Identifiers for NGF Gene

  • GC01M115630
  • GC01M115828
  • GC01M113686

Summaries for NGF Gene

Entrez Gene Summary for NGF Gene

  • This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

GeneCards Summary for NGF Gene

NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are ERK Signaling and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3.

UniProtKB/Swiss-Prot for NGF Gene

  • Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).

Tocris Summary for NGF Gene

  • Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.

Gene Wiki entry for NGF Gene

Additional gene information for NGF Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGF Gene

Genomics for NGF Gene

GeneHancer (GH) Regulatory Elements for NGF Gene

Promoters and enhancers for NGF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J115337 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 656.1 +0.3 292 1.5 ZSCAN4 SIN3A ZNF2 ZNF335 ZNF121 ZNF23 GLIS2 ZNF366 ZNF398 ZNF623 NGF ENSG00000228035
GH01J115329 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +6.3 6333 4.6 JUN MAX CEBPG RFX5 ZNF366 FOS TRIM24 SOX6 RXRA BHLHE40 NGF ENSG00000228035
GH01J115188 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +148.1 148111 3.1 JUN MAX SIN3A RFX5 POLR2A SMC3 NFE2 FOSL2 FOS MAFK NGF ENSG00000228035 SIKE1 GC01P115161 LOC105378917
GH01J115411 Enhancer 1 Ensembl ENCODE 17.6 -73.4 -73401 0.4 FOXA2 FEZF1 RAD21 RFX5 YY1 ZNF366 ZSCAN5C ZNF350 RCOR1 FOS NGF TRIM33 ENSG00000228035 ENSG00000226973
GH01J115314 Enhancer 0.8 ENCODE dbSUPER 19 +23.6 23567 1.3 MNT FOXA1 SREBF1 CTBP1 ZFHX2 POLR2A MAFK EGR2 NGF ENSG00000228035
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NGF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NGF gene promoter:
  • AP-2alpha isoform 4
  • AP-2alpha isoform 3
  • AP-2alpha isoform 2
  • AP-2alpha
  • AP-2alphaA
  • FOXO1a
  • FOXO1
  • STAT3
  • deltaCREB
  • STAT5A

Genomic Locations for NGF Gene

Genomic Locations for NGF Gene
chr1:115,285,916-115,338,384
(GRCh38/hg38)
Size:
52,469 bases
Orientation:
Minus strand
chr1:115,828,537-115,880,857
(GRCh37/hg19)
Size:
52,321 bases
Orientation:
Minus strand

Genomic View for NGF Gene

Genes around NGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGF Gene

Proteins for NGF Gene

  • Protein details for NGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01138-NGF_HUMAN
    Recommended name:
    Beta-nerve growth factor
    Protein Accession:
    P01138
    Secondary Accessions:
    • A1A4E5
    • Q6FHA0
    • Q96P60
    • Q9P2Q8
    • Q9UKL8

    Protein attributes for NGF Gene

    Size:
    241 amino acids
    Molecular mass:
    26959 Da
    Quaternary structure:
    • Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.
    SequenceCaution:
    • Sequence=AAH32517.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NGF Gene

neXtProt entry for NGF Gene

Post-translational modifications for NGF Gene

  • Glycosylation at isoforms=114, isoforms=69, and Thr46
  • Modification sites at PhosphoSitePlus

Other Protein References for NGF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NGF
  • Santa Cruz Biotechnology (SCBT) Antibodies for NGF

No data available for DME Specific Peptides for NGF Gene

Domains & Families for NGF Gene

Gene Families for NGF Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for NGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01138

UniProtKB/Swiss-Prot:

NGF_HUMAN :
  • Belongs to the NGF-beta family.
Family:
  • Belongs to the NGF-beta family.
genes like me logo Genes that share domains with NGF: view

Function for NGF Gene

Molecular function for NGF Gene

UniProtKB/Swiss-Prot Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).

LifeMap Function Summary for NGF Gene

Phenotypes From GWAS Catalog for NGF Gene

Gene Ontology (GO) - Molecular Function for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0005102 signaling receptor binding IEA --
GO:0005163 nerve growth factor receptor binding IPI 14985763
GO:0005515 protein binding IPI 10490030
GO:0008083 growth factor activity IBA --
genes like me logo Genes that share ontologies with NGF: view
genes like me logo Genes that share phenotypes with NGF: view

Human Phenotype Ontology for NGF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NGF Gene

MGI Knock Outs for NGF:
  • Ngf Ngf<tm1Gne>
  • Ngf Ngf<tm1Ddg>

Animal Model Products

miRNA for NGF Gene

miRTarBase miRNAs that target NGF

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NGF Gene

Localization for NGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NGF gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endosome 5
cytoskeleton 3
nucleus 3
plasma membrane 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
lysosome 2

Gene Ontology (GO) - Cellular Components for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA,TAS --
GO:0005615 extracellular space IBA --
GO:0005768 endosome TAS --
GO:0005796 Golgi lumen TAS --
GO:0008021 synaptic vesicle IBA --
genes like me logo Genes that share ontologies with NGF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NGF Gene

Pathways & Interactions for NGF Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 p75 NTR receptor-mediated signalling
3 RET signaling
4 GPCR Pathway
5 ERK Signaling
genes like me logo Genes that share pathways with NGF: view

Pathways by source for NGF Gene

SIGNOR curated interactions for NGF Gene

Activates:

Gene Ontology (GO) - Biological Process for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007018 microtubule-based movement TAS --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007267 cell-cell signaling IBA --
genes like me logo Genes that share ontologies with NGF: view

Drugs & Compounds for NGF Gene

(94) Drugs for NGF Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clenbuterol Approved, Investigational, Vet_approved Pharma Target, stimulator 3
Polaprezinc Approved, Investigational Pharma Target, agonist 2
Methadone Approved Pharma 341
RI 624 Investigational Pharma Target 0
CERE-110 Investigational Pharma 0

(53) Additional Compounds for NGF Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AG 879
148741-30-4
LM11A 31 dihydrochloride
1243259-19-9

(4) Tocris Compounds for NGF Gene

Compound Action Cas Number
AG 879 TrkA inhibitor 148741-30-4
BDNF (human) Activates TrkB and p75 receptors 218441-99-7
LM11A 31 dihydrochloride Nonpeptide p75NTR ligand; neuroprotective 1243259-19-9
TLQP 21 VGF-derived peptide 869988-94-3
genes like me logo Genes that share compounds with NGF: view

Drug Products

Transcripts for NGF Gene

mRNA/cDNA for NGF Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NGF Gene

Nerve growth factor (beta polypeptide):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NGF Gene

No ASD Table

Relevant External Links for NGF Gene

GeneLoc Exon Structure for
NGF
ECgene alternative splicing isoforms for
NGF

Expression for NGF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NGF Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.7), Ovary (x4.6), and Artery - Aorta (x4.2).

Protein differential expression in normal tissues from HIPED for NGF Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NGF Gene



Protein tissue co-expression partners for NGF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NGF Gene:

NGF

SOURCE GeneReport for Unigene cluster for NGF Gene:

Hs.2561

Evidence on tissue expression from TISSUES for NGF Gene

  • Nervous system(4.8)
  • Blood(4.5)
  • Eye(4.5)
  • Adrenal gland(3.9)
  • Muscle(2.6)
  • Skin(2.5)
  • Heart(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NGF Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • integumentary
  • nervous
  • skeleton
Regions:
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood vessel
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with NGF: view

No data available for mRNA Expression by UniProt/SwissProt for NGF Gene

Orthologs for NGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for NGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NGF 34 33
  • 99.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NGF 34 33
  • 87.97 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NGF 33
  • 87.41 (n)
NGFB 34
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ngf 33
  • 85.62 (n)
mouse
(Mus musculus)
Mammalia Ngf 16 34 33
  • 85.48 (n)
oppossum
(Monodelphis domestica)
Mammalia NGF 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NGF 34 33
  • 70.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NGFB 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ngf 33
  • 69.05 (n)
zebrafish
(Danio rerio)
Actinopterygii ngf 34
  • 51 (a)
OneToMany
ntf7 34 33
  • 44 (a)
OneToMany
Species where no ortholog for NGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGF Gene

ENSEMBL:
Gene Tree for NGF (if available)
TreeFam:
Gene Tree for NGF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NGF: view image

Paralogs for NGF Gene

Paralogs for NGF Gene

(3) SIMAP similar genes for NGF Gene using alignment to 1 proteins:

  • NGF_HUMAN
genes like me logo Genes that share paralogs with NGF: view

Variants for NGF Gene

Sequence variations from dbSNP and Humsavar for NGF Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1011323001 uncertain-significance, Congenital sensory neuropathy with selective loss of small myelinated fibers 115,286,425(-) G/A coding_sequence_variant, missense_variant
rs11466110 benign, Congenital sensory neuropathy with selective loss of small myelinated fibers 115,286,582(-) C/T coding_sequence_variant, missense_variant
rs11466111 conflicting-interpretations-of-pathogenicity, Congenital sensory neuropathy with selective loss of small myelinated fibers 115,286,557(-) C/T coding_sequence_variant, missense_variant
rs11466112 pathogenic, Congenital sensory neuropathy with selective loss of small myelinated fibers, Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654] 115,286,135(-) G/A coding_sequence_variant, missense_variant
rs147763877 uncertain-significance, Congenital sensory neuropathy with selective loss of small myelinated fibers, not specified 115,286,461(-) G/C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for NGF Gene

Variant ID Type Subtype PubMed ID
esv26121 CNV loss 19812545
esv34370 CNV gain 17911159
nsv159371 CNV deletion 16902084
nsv818389 CNV gain 17921354

Variation tolerance for NGF Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.58; 86.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NGF Gene

Human Gene Mutation Database (HGMD)
NGF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NGF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGF Gene

Disorders for NGF Gene

MalaCards: The human disease database

(78) MalaCards diseases for NGF Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neuropathy, hereditary sensory and autonomic, type v
  • indifference to pain, congenital, autosomal recessive
autonomic neuropathy
corneal ulcer
anhidrosis
  • absence of sweating
cystitis
  • infective cystitis
- elite association - COSMIC cancer census association via MalaCards
Search NGF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NGF_HUMAN
  • Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable. {ECO:0000269 PubMed:14976160, ECO:0000269 PubMed:20978020, ECO:0000269 PubMed:22302274}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NGF

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NGF: view

No data available for Genatlas for NGF Gene

Publications for NGF Gene

  1. A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy. (PMID: 20978020) Carvalho OP … Woods CG (Journal of medical genetics 2011) 3 4 58
  2. Nerve growth factor promotes cardiac repair following myocardial infarction. (PMID: 20360245) Meloni M … Emanueli C (Circulation research 2010) 3 22 58
  3. Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI. (PMID: 20164177) Wijeyewickrema LC … Andrews RK (The Journal of biological chemistry 2010) 3 4 58
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 44 58

Products for NGF Gene

Sources for NGF Gene

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