Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NFKBIE Gene

Aliases for NFKBIE Gene

  • NFKB Inhibitor Epsilon 2 3 5
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Epsilon 2 3
  • NF-Kappa-B Inhibitor Epsilon 2 3
  • I-Kappa-B-Epsilon 3 4
  • IkappaBepsilon 3 4
  • NF-Kappa-BIE 3 4
  • IkB-Epsilon 3 4
  • IkB-E 3 4
  • IKBE 3 4

External Ids for NFKBIE Gene

Previous GeneCards Identifiers for NFKBIE Gene

  • GC06M044224
  • GC06M044273
  • GC06M044334
  • GC06M043947

Summaries for NFKBIE Gene

Entrez Gene Summary for NFKBIE Gene

  • The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]

GeneCards Summary for NFKBIE Gene

NFKBIE (NFKB Inhibitor Epsilon) is a Protein Coding gene. Diseases associated with NFKBIE include Pneumococcal Meningitis and Ebola Hemorrhagic Fever. Among its related pathways are T cell receptor signaling pathway and Bacterial infections in CF airways. An important paralog of this gene is BCL3.

UniProtKB/Swiss-Prot for NFKBIE Gene

  • Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene Wiki entry for NFKBIE Gene

Additional gene information for NFKBIE Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBIE Gene

Genomics for NFKBIE Gene

GeneHancer (GH) Regulatory Elements for NFKBIE Gene

Promoters and enhancers for NFKBIE Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J044255 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 684.6 +4.8 4844 11.9 CLOCK ZFP64 DMAP1 YBX1 IRF4 YY1 E2F8 ZNF143 ZNF263 SP3 NFKBIE SLC35B2 ABCC10 ZNF318 RPL34P14 AARS2 RPS2P29 GTPBP2 POLH POLR1C
GH06J044056 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 30.6 +203.5 203530 12 MLX YY1 SLC30A9 E2F8 ZNF143 ZNF548 MEF2D GLIS1 RCOR2 NBN POLH GTPBP2 ZNF318 NFKBIE ABCC10 RPS2P29 MRPL14 TMEM63B XPO5 POLR1C
GH06J044236 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +27.9 27884 2.4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 GC06P044236 RPL34P14 AARS2 ZNF318 NFKBIE ABCC10 CAPN11 MRPL14 TMEM63B SPATS1
GH06J044125 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.5 +138.4 138420 3.3 HDGF PKNOX1 ARNT ARID4B DMAP1 YY1 POLR2B ZNF766 JUNB MXD4 MRPL14 TMEM63B POLH ZNF318 XPO5 RPS2P29 POLR1C GTPBP2 AARS2 NFKBIE
GH06J044033 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +230.2 230186 3.6 TFAP4 SREBF2 MAX EBF1 CEBPG ZNF644 RAD21 ZNF48 TEAD3 SLC30A9 NFKBIE C6orf223 VEGFA RSPH9 SLC29A1 GTPBP2 MAD2L1BP GC06P044013 LOC101929705 GC06M044069
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NFKBIE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NFKBIE gene promoter:
  • Egr-2
  • Egr-4
  • RORalpha1
  • Elk-1
  • GATA-3
  • ISGF-3
  • E47
  • c-Myb
  • IRF-2
  • MyoD

Genomic Locations for NFKBIE Gene

Genomic Locations for NFKBIE Gene
7,623 bases
Minus strand
7,623 bases
Minus strand

Genomic View for NFKBIE Gene

Genes around NFKBIE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBIE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBIE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBIE Gene

Proteins for NFKBIE Gene

  • Protein details for NFKBIE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NF-kappa-B inhibitor epsilon
    Protein Accession:
    Secondary Accessions:
    • Q5T9V9

    Protein attributes for NFKBIE Gene

    500 amino acids
    Molecular mass:
    52864 Da
    Quaternary structure:
    • Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit.
    • Sequence=AAC51216.1; Type=Frameshift; Positions=339, 351; Evidence={ECO:0000305};

neXtProt entry for NFKBIE Gene

Post-translational modifications for NFKBIE Gene

  • Serine phosphorylated; followed by proteasome-dependent degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFKBIE Gene

Antibody Products

No data available for DME Specific Peptides for NFKBIE Gene

Domains & Families for NFKBIE Gene

Gene Families for NFKBIE Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NFKBIE Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NF-kappa-B inhibitor family.
  • Belongs to the NF-kappa-B inhibitor family.
genes like me logo Genes that share domains with NFKBIE: view

Function for NFKBIE Gene

Molecular function for NFKBIE Gene

UniProtKB/Swiss-Prot Function:
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Phenotypes From GWAS Catalog for NFKBIE Gene

Gene Ontology (GO) - Molecular Function for NFKBIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with NFKBIE: view
genes like me logo Genes that share phenotypes with NFKBIE: view

Animal Models for NFKBIE Gene

MGI Knock Outs for NFKBIE:

Animal Model Products

miRNA for NFKBIE Gene

miRTarBase miRNAs that target NFKBIE

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFKBIE Gene

Localization for NFKBIE Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBIE Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFKBIE gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NFKBIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm TAS 9135156
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NFKBIE: view

Pathways & Interactions for NFKBIE Gene

genes like me logo Genes that share pathways with NFKBIE: view

SIGNOR curated interactions for NFKBIE Gene


Gene Ontology (GO) - Biological Process for NFKBIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042942 D-serine transport IEA --
GO:0042994 cytoplasmic sequestering of transcription factor TAS 9135156
genes like me logo Genes that share ontologies with NFKBIE: view

Drugs & Compounds for NFKBIE Gene

No Compound Related Data Available

Transcripts for NFKBIE Gene


(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(521) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NFKBIE Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIE Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP3: -

Relevant External Links for NFKBIE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NFKBIE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFKBIE Gene

Protein differential expression in normal tissues from HIPED for NFKBIE Gene

This gene is overexpressed in Breast (34.2), Peripheral blood mononuclear cells (11.8), Blymphocyte (8.7), and Monocytes (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NFKBIE Gene

NURSA nuclear receptor signaling pathways regulating expression of NFKBIE Gene:


SOURCE GeneReport for Unigene cluster for NFKBIE Gene:


mRNA Expression by UniProt/SwissProt for NFKBIE Gene:

Tissue specificity: Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.

Evidence on tissue expression from TISSUES for NFKBIE Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NFKBIE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFKBIE Gene

Orthologs for NFKBIE Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBIE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NFKBIE 34 33
  • 99.33 (n)
(Bos Taurus)
Mammalia NFKBIE 34 33
  • 86.43 (n)
(Canis familiaris)
Mammalia NFKBIE 34 33
  • 84.72 (n)
(Mus musculus)
Mammalia Nfkbie 16 34 33
  • 82.41 (n)
(Rattus norvegicus)
Mammalia Nfkbie 33
  • 82.27 (n)
(Ornithorhynchus anatinus)
Mammalia NFKBIE 34
  • 72 (a)
(Monodelphis domestica)
Mammalia NFKBIE 34
  • 72 (a)
(Gallus gallus)
Aves NFKBIE 34 33
  • 66.37 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 17 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145466 33
  • 60.08 (n)
Str.672 33
(Danio rerio)
Actinopterygii nfkbie 34 33
  • 53.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta cact 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
Species where no ortholog for NFKBIE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFKBIE Gene

Gene Tree for NFKBIE (if available)
Gene Tree for NFKBIE (if available)
Evolutionary constrained regions (ECRs) for NFKBIE: view image

Paralogs for NFKBIE Gene

Paralogs for NFKBIE Gene

(4) SIMAP similar genes for NFKBIE Gene using alignment to 5 proteins:

  • H0Y4W4_HUMAN
  • Q7LC14_HUMAN
  • Q96F31_HUMAN
genes like me logo Genes that share paralogs with NFKBIE: view

Variants for NFKBIE Gene

Sequence variations from dbSNP and Humsavar for NFKBIE Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000289298 -- 44,260,996(-) G/A intron_variant
rs1000856370 -- 44,261,563(-) C/T intron_variant
rs1000894460 -- 44,259,307(-) G/A intron_variant
rs1001042814 -- 44,265,743(-) C/G coding_sequence_variant, missense_variant
rs1001189057 -- 44,259,908(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NFKBIE Gene

Variant ID Type Subtype PubMed ID
dgv10641n54 CNV loss 21841781
nsv462936 CNV loss 19166990
nsv524398 CNV loss 19592680
nsv5282 CNV insertion 18451855
nsv603003 CNV gain 21841781

Variation tolerance for NFKBIE Gene

Gene Damage Index Score: 5.20; 69.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NFKBIE Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBIE Gene

Disorders for NFKBIE Gene

MalaCards: The human disease database

(3) MalaCards diseases for NFKBIE Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pneumococcal meningitis
  • meningitis, pneumococcal
ebola hemorrhagic fever
  • ebola virus disease
pleural empyema
  • abscess of pleural cavity
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NFKBIE

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NFKBIE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFKBIE Gene

Publications for NFKBIE Gene

  1. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R … Gonzalez A (Annals of the rheumatic diseases 2009) 3 22 44 58
  2. IkappaB genetic polymorphisms and invasive pneumococcal disease. (PMID: 17463416) Chapman SJ … Hill AV (American journal of respiratory and critical care medicine 2007) 3 22 44 58
  3. I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. (PMID: 9135156) Whiteside ST … Israël A (The EMBO journal 1997) 2 3 4 58
  4. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y … Yamamoto K (Nature genetics 2012) 3 44 58
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58

Products for NFKBIE Gene

Sources for NFKBIE Gene