Aliases for NEDD8 Gene
External Ids for NEDD8 Gene
Previous GeneCards Identifiers for NEDD8 Gene
GeneCards Summary for NEDD8 Gene
NEDD8 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 8) is a Protein Coding gene. Diseases associated with NEDD8 include Parkinson Disease, Late-Onset. Among its related pathways are Metabolism of proteins and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding.
UniProtKB/Swiss-Prot for NEDD8 Gene
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.